Mitochondria-Targeted Hydropersulfide Donors to Treat Anthracycline-Induced Cardiotoxicity

线粒体靶向氢过硫化物供体治疗蒽环类药物引起的心脏毒性

• 批准号: 10798654
• 负责人: John P Toscano
• 金额: $ 5.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10798654
• 关键词: Anthracycline; Budgets; Cardiotoxicity; Consumption; Data Collection; Detection; Equipment; Fluorescence; Mitochondria; Research; System; Time; detector; improved

PROJECT SUMMARY/ABSTRACT An equipment supplement to the budget of 1 R01GM145940-01 is requested for the purchase of an Agilent 1260 Infinity II LC System with autosampler, fluorescence, and diode array detectors. Analytical analysis of product mixtures from our newly developed hydropersulfide (RSSH) donors is a major, and time-consuming, component of the proposed research in Specific Aim 1 of GM145940. This new LC system will greatly improve the efficiency of data collection and will also expand detection capabilities.

项目概要/摘要 请求对 1 R01GM145940-01 预算进行设备补充，用于购买 配备自动进样器、荧光和二极管阵列检测器的 Agilent 1260 Infinity II 液相色谱系统。 对我们新开发的氢过硫化物 (RSSH) 的产品混合物进行分析分析 捐助者是具体目标 1 中拟议研究的一个主要且耗时的组成部分 GM145940。这种新的液相色谱系统将大大提高数据收集的效率，并将 还扩大了检测能力。