Research Program

研究计划

基本信息

批准号：
10633093
负责人：
Jennifer Jean Trowbridge
金额：
$ 4.91万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10633093
关键词：
Abbreviations Adverse effects Animal Model Antigen-Presenting Cells Area Basic Science Biological Biological Models Biological Process Budgets Cancer Biology Cancer Center Cancer Center Support Grant Cancer Model Cancer Vaccines Cell model Chromosomal Rearrangement Cities Clinical Collaborations Complement Complex Computational Science Computational algorithm Computer Models Computing Methodologies Connecticut DNA Damage DNA Repair Pathway DNA Sequence Alteration Data Set Development Direct Costs Discipline Evolution Extracellular Matrix Faculty Recruitment Fostering Foundations Funding Future Genetic Genetic Engineering Genetic Models Genetic Variation Genome Genomic Instability Genomics Goals Grant Health Immune checkpoint inhibitor Immunodeficient Mouse Immunologics Immunotherapy Investigation Israel Knowledge Laboratories Leadership Maine Malignant Neoplasms Mediator Medical center Medicine Methods Modeling Mus Mutation NCI Center for Cancer Research Names Oncogene Activation Output Patients Pediatric Hospitals Peer Review Phenotype Property Proteins Publications Records Research Research Personnel Research Project Summaries Research Support Resistance Resource Development Resources Sampling Shapes Southwest Oncology Group System Technology Telomere Maintenance The Jackson Laboratory Travel Tumor Suppressor Proteins Tumorigenicity United States National Institutes of Health Universities Vision Work anticancer research behavioral response biological systems biomarker validation cancer cell cancer genomics cancer therapy candidate marker chemotherapy computing resources design functional genomics genetic resource genomic aberrations in vitro Model in vivo in vivo Model innovation innovative technologies meetings member model development neoplastic cell new technology novel patient derived xenograft model precision medicine precision oncology programs resistance mechanism response single cell technology technological innovation technology platform therapeutic target therapy resistant translational potential treatment response tumor

项目摘要

PROJECT SUMMARY RESEARCH PROGRAM The overarching goal of the JAX Cancer Center (JAXCC) Research Program, Genetic Models for Precision Cancer Medicine, is to advance the vision of precision oncology through basic research discoveries with potential for translational and clinical impact. Members use diverse, multi-scale strategies to deconvolute complex cancer systems to their principal components and to investigate the drivers of cancer cell complexity, tumor evolution, and tumor adaptation. Elucidating these fundamental biological processes are key to a principled, mechanistic understanding of the adverse effects of cancer therapy and of treatment resistance. During the current funding period we have expanded, and reshaped, the JAXCC into a new cancer research force with a focus on complex genetics and functional genomics. Research is organized around three complementary Specific Aims. Aim 1 seeks to develop novel organismal, cellular, and computational models of cancer, drawing on the JAXCC's longstanding strengths in model development. Aim 2 examines the genomic instability and genetic complexity of cancer and determines their functional consequences in the cancer cell. Using advanced computational methods and genomic technologies we will interrogate animal models developed in Aim 1 as well as patient samples. Aim 3 investigates how key components of a tumor and the host contribute to cancer biology, examining the cancer cell intrinsic and extrinsic components of a malignant tumor. Results from studies in Aim 3, integrated with the genetic alterations identified in Aim 2 with models developed in Aim 1, will allow us to deconvolute the complex interactions of the tumor and host microenvironments. The 53 full program members of the JAXCC include 33 on the Bar Harbor campus and 20 on the Farmington campus. Through its emphasis on basic research, unique model development, and technological innovation, the program leverages funding from multiple NIH ICs in support of cancer-focused research. More recently, we brought our technologies into the clinical arena through collaborations with SWOG, the Maine Cancer Genomics Initiative, City of Hope, Beth Israel Deaconess Medical Center, University of Connecticut Health Center, and the Connecticut Children's Hospital. The program is supported by $10,401,511 direct costs in NCI and other peer- reviewed cancer-related grants in the last budget year. Over the last grant cycle, CCSG funds have supported 379 publications including 30% intra-programmatic collaborations and 72% with external collaborators. The efforts of the Co-Program Leaders, Drs. Karolina Palucka and Roel Verhaak, and JAXCC leadership have fostered interactivity among JAXCC members through regular Research Program meetings, subsidized travel between campuses, and the JAXCC Annual Retreat. The annual JAXCC Retreat and monthly program meetings are the primary forums that bring together Cancer Center members from both campuses to develop intra- programmatic collaborations and to participate in the planning for resource development and faculty recruitment.

项目摘要研究计划 JAX癌症中心（JAXCC）研究计划的总体目标，精确的遗传模型癌症医学是通过与潜在的翻译和临床影响。成员使用多样化的多尺度策略来宣传复杂的癌症系统与其主要成分，并研究癌细胞复杂性的驱动因素，肿瘤演化和肿瘤适应。阐明这些基本的生物学过程是原则上对癌症治疗和治疗耐药性的不良影响的机械理解。在当前的资金期间，我们已经扩展并重塑了JAXCC，将侧重于复杂遗传学和功能基因组学的力。研究大约是三个互补的特定目的。 AIM 1试图开发新的生物，细胞和计算模型癌症，借鉴JAXCC在模型开发方面的长期优势。 AIM 2检查基因组癌症的不稳定性和遗传复杂性，并确定其在癌细胞中的功能后果。使用先进的计算方法和基因组技术，我们将询问开发的动物模型在AIM 1和患者样品中。 AIM 3调查了肿瘤和宿主的关键成分如何贡献为了癌症生物学，检查恶性肿瘤的癌细胞固有和外在成分。结果根据AIM 3的研究，与AIM 2中确定的遗传变量整合在一起，与AIM 1中开发的模型，将使我们能够解散肿瘤和宿主微环境的复杂相互作用。 53满 JAXCC的计划成员在Bar Harbour校园内包括33个，在Farmington校园中包括20名。通过强调基础研究，独特的模型开发和技术创新，该计划利用多个NIH IC的资金来支持以癌症为中心的研究。最近，我们带来了我们的通过与缅因州癌症基因组学计划Swog的合作，进入临床领域的技术，希望之城，贝丝以色列女执事医疗中心，康涅狄格大学健康中心和康涅狄格州儿童医院。该计划由NCI和其他同行的10,401,511 $ 10,401,511的直接费用支持在上一个预算中审查了与癌症相关的补助金。在上一个赠款周期中，CCSG资金支持 379个出版物，包括30％的杂项内合作，以及与外部合作者的72％。这联合计划领导者的努力，博士。 Karolina Palucka和Roel Verhaak和Jaxcc领导通过常规的研究计划会议，补贴旅行来促进JAXCC成员之间的互动在校园之间和JAXCC年度静修处。年度JAXCC务虚会和月度课程会议是将两个校园的癌症中心成员聚集在一起以发展内部的主要论坛计划合作，并参与资源开发和教师招聘的计划。