Role of fatty acid metabolism for the prevention of sudden cardiac death

脂肪酸代谢在预防心源性猝死中的作用

基本信息

批准号：
8792865
负责人：
Stephanie Elizabeth Chiuve
金额：
$ 24.8万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-11-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8792865
关键词：
Accounting Age Alcohols Antioxidants Arachidonic Acids Award Biological Assay Biological Markers Blood Blood Cells Body mass index Cardiac Cessation of life Cohort Studies Conflict (Psychology)Diet Dietary Fatty Acid Dietary intake Disease Enzymes Fatty Acid Desaturases Fatty Acids Funding Gender Genes Genetic Genetic Variation Goals Heart Diseases Individual Intake Knowledge Linoleic Acids Measurement Measures Mentors Methods Omega-3 Fatty Acids Patients Phase Physical activity Polyunsaturated Fatty Acids Population Characteristics Prevention Preventive Intervention Research Research Training Risk Role Smoking Strategic Planning Subgroup Training Treatment Cost United States National Institutes of Health Variant Woman career development fatty acid metabolism feeding high risk long chain fatty acid men nutritional epidemiology patient population prevent prospective skills sudden cardiac death symposium

项目摘要

Sudden cardiac death (SCD) accounts for -50% of all CHD deaths and, forthe majority of victims, SCD is the first manifestation of heart disease. There is an accumulating body of evidence that fatty acids, particularly n-3 fatty acids, hold great promise as predictors of and preventive interventions against SGD, although studies have been inconsistent. These conflicting results may be due to differences in population characteristics (with and without CHD; men v. women) or methods of fatty acid assessment (dietary intake v. biomarker levels). Thus, more research is needed to understand the differences in risk among these various subgroups and to evaluate different methods of fatty acid measurements. Additionally, genetic and environmental influences on fatty acid metabolism are not well understood. During the K99 award, Dr Chiuve successfully implemerited a comprehensive training plan, which inclijded mentored training through the analysis of dietary fatty acids and genetic influences of fatty acid rnetabolism and risk of SCD, other significant scientific research training, attendance at seminars and researeh conferences and nonscientific career development. She has gained the knowledge and skills necessary for the transition into an independenfinyestigator in the field of "Nutritional Epidemiology of Cardiac Arrhytmic Disorders". During the ROO phase of the award. Dr. Chiuve w.iil assay fatty acids in fed blood cells and.examine their association with risk of SCD. She will also exaniine the influence of genetic variation in RBC fatty acids. She will investigate these aims within 6 large, NIH-funded prospective cohort studies that include both men and women and individuals with and without established CHD. Strengths of this proposalinclude the use of dietary and RBC fatty acid measures as means to predict individuals at high risk of SCD and the identification of subgroups that may benefit from a low-cost treatment such as modifying dietary fatty acid intake. These aims correspond to one goal in the NHLBl's strategic plan to "develop means to predict and prevent sudden cardiac death".

心源性猝死 (SCD) 占所有 CHD 死亡的 -50%，对于大多数受害者来说，SCD 是心脏病的第一个表现。越来越多的证据表明脂肪酸，特别是 n-3 脂肪酸，作为 SGD 的预测因子和预防性干预措施具有广阔的前景，尽管研究结果不一致。这些相互矛盾的结果可能是由于人口差异造成的特征（有或没有先心病；男性与女性）或脂肪酸评估方法（膳食摄入量与脂肪酸）生物标志物水平）。因此，需要更多的研究来了解这些不同类型之间的风险差异。亚组并评估不同的脂肪酸测量方法。此外，遗传和环境对脂肪酸代谢的影响尚不清楚。在K99颁奖期间，博士 Chiuve 成功地实施了一项全面的培训计划，其中包括通过以下方式进行指导培训：膳食脂肪酸分析以及脂肪酸代谢的遗传影响和 SCD 风险，其他重要的科学研究培训、参加研讨会和研究会议以及非科学职业发展。她已经获得了过渡到职业生涯所需的知识和技能 “心律失常疾病的营养流行病学”领域的独立研究者。期间 ROO 阶段的奖项。 Chiuve 博士将测定喂食血细胞中的脂肪酸并检查它们的关联有发生 SCD 的风险。她还将检查红细胞脂肪酸遗传变异的影响。她会在 NIH 资助的 6 项大型前瞻性队列研究中调查这些目标，其中包括男性和女性患有或未患有先天性心脏病的女性和个人。该提案的优点包括使用饮食和红细胞脂肪酸测量作为预测 SCD 高风险个体的手段确定可能受益于低成本治疗（例如改变膳食脂肪酸）的亚组摄入量。这些目标与 NHLBl 战略计划中的一个目标相对应，即“开发预测和预测的方法”。预防心源性猝死”。