Developmental Research Program

发展研究计划

• 批准号: 10706334
• 负责人: CELINE M VACHON
• 金额: $ 14.89万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706334
• 关键词: Area; Basic Science; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Development; Discipline; Fostering; Foundations; Funding; Future; Goals; Grant; Incidence; Infrastructure; Laboratory Study; Mayo Clinic Cancer Center; Monitor; Multiple Myeloma; Patients; Pilot Projects; Quality of life; Recommendation; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Techniques; Testing; Translating; Translational Research; United States National Institutes of Health; clinical translation; improved; improved outcome; innovation; mortality; novel; programs; sound; translational study; tumor

ABSTRACT: Developmental Research Program (DRP). The goal of the Developmental Research Program in the Mayo Clinic SPORE in Multiple Myeloma is to support innovative, scientifically sound projects that investigate any area pertaining to translational myeloma research. Funding from this program will stimulate developmental research that incorporates techniques and theoretical approaches that may not have been previously utilized in myeloma research. In so doing it provides a mechanism by which the SPORE can increase the number of scientists and clinical investigators who are committed to translational myeloma research. The Developmental Research Program will encourage the development of suitable projects, coordinate project review and selection, make funding recommendations to the Executive Committee, and monitor research progress. We have requested $140,000 annually ($90,000 per year from the SPORE funds augmented by $50,000 per year in matching funds from the Mayo Clinic Cancer Center) for the Developmental Research Program. We aim to provide research support to three to four projects per year for one year with a second year of support possible based on exceptional progress towards the stated aims of the project. The long term goal is to translate the findings generated by developmental projects into a reduction in the incidence and mortality rates of myeloma. Without the funding, infrastructure, and expertise of the SPORE projects and investigators, it will be unlikely that innovative developmental research projects of the kind we envision can be brought to fruition. Specifically, the primary goals of the Developmental Research Program are to: (1) encourage innovative translational studies that are promising and have the potential to improve outcome in myeloma and mature into independently funded projects; (2) foster extensive collaboration between basic science and clinical disciplines in translational research in myeloma in the context of the myeloma SPORE program; (3) encourage investigators to apply their research findings in other tumor types to translational research in myeloma and; (4) generate new hypotheses that can be tested and provide the foundation for future largescale research projects or clinical trials in order to reduce myeloma incidence and mortality rates.

摘要：发展研究计划（DRP）。发展研究计划的目标 在多发性骨髓瘤的梅奥诊所孢子中 研究与转化骨髓瘤研究有关的任何区域。该计划的资金将刺激 结合了可能没有的技术和理论方法的发展研究 以前在骨髓瘤研究中使用。这样做提供了一种机制 增加致力于转化骨髓瘤的科学家和临床研究者的数量 研究。发展研究计划将鼓励开发合适的项目， 协调项目审查和选择，向执行委员会提出资金建议，然后 监控研究进度。我们每年要求$ 140,000（每年从孢子资金中$ 90,000 每年从梅奥诊所癌症中心获得50,000美元的匹配资金） 研究计划。我们旨在为一年的每年三到四个项目提供研究支持 基于对项目的既定目标的出色进步，可能的支持第二年。这 长期目标是将发展项目产生的发现转化为降低发病率 和骨髓瘤的死亡率。没有孢子项目的资金，基础设施和专业知识 调查人员，我们所设想的创新性发展研究项目不太可能 实现。具体而言，发展研究计划的主要目标是：（1） 鼓励具有希望的创新转化研究，并有可能改善结果 骨髓瘤并成熟成独立资助的项目； （2）促进基本之间的广泛合作 在骨髓瘤孢子的背景下，骨髓瘤转化研究的科学和临床学科 程序; （3）鼓励研究人员将其研究结果应用于其他肿瘤类型 骨髓瘤的研究； （4）产生可以测试的新假设，并为 未来的LargesCale研究项目或临床试验，以降低骨髓瘤的发病率和死亡率。