Core A: Administrative Core

核心A：行政核心

基本信息

批准号：
10705723
负责人：
SCOTT Michael SCHUETZE
金额：
$ 25.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705723
关键词：
Accounting Address Advocate Award Awareness Biology Cancer Biology Cancer Center Clinic Clinical Clinical Research Clinical Trials Clinical Trials Support Unit Collaborations Committee Membership Communication Comprehensive Cancer Center DNA Repair Development Diagnosis Disease Ensure Eye Foundations Funding Genetic Genomics Germ-Line Mutation Goals Grant Group Meetings Infrastructure Institution Internal Medicine Knowledge Laboratories Leadership Liquid substance Malignant Fibrous Histiocytoma Medical Oncologist Medicine Michigan Mission Monitor Outcome Patient Care Patient-Focused Outcomes Patients Persons Physician Executives Positioning Attribute Principal Investigator Progress Reports Publications Research Research Personnel Research Project Grants Resources Science Scientist Site Soft tissue sarcoma Southwest Oncology Group Structure Susceptibility Gene TP53 gene Translational Research Tumor Markers Underrepresented Populations United States National Institutes of Health Universities Voice Work cancer clinical trial cancer genetics cancer predisposition cancer prevention career clinical translation data sharing diversity and inclusion expectation experience flexibility improved innovation leiomyosarcoma medical schools meetings member mid-career faculty multi-site trial novel strategies operation osteosarcoma professor prognostic programs radiologist recruit sarcoma skills translational goal translational scientist webinar

Accounting Address Advocate Award Awareness Biology Cancer Biology Cancer Center Clinic Clinical Clinical Research Clinical Trials Clinical Trials Support Unit Collaborations Committee Membership Communication Comprehensive Cancer Center DNA Repair Development Diagnosis Disease Ensure Eye Foundations Funding Genetic Genomics Germ-Line Mutation Goals Grant Group Meetings Infrastructure Institution Internal Medicine Knowledge Laboratories Leadership Liquid substance Malignant Fibrous Histiocytoma Medical Oncologist Medicine Michigan Mission Monitor Outcome Patient Care Patient-Focused Outcomes Patients Persons Physician Executives Positioning Attribute Principal Investigator Progress Reports Publications Research Research Personnel Research Project Grants Resources Science Scientist Site Soft tissue sarcoma Southwest Oncology Group Structure Susceptibility Gene TP53 gene Translational Research Tumor Markers Underrepresented Populations United States National Institutes of Health Universities Voice Work cancer clinical trial cancer genetics cancer predisposition cancer prevention career clinical translation data sharing diversity and inclusion expectation experience flexibility improved innovation leiomyosarcoma medical schools meetings member mid-career faculty multi-site trial novel strategies operation osteosarcoma professor prognostic programs radiologist recruit sarcoma skills translational goal translational scientist webinar

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项目摘要

Core A - Administrative Core: Project Summary / Abstract The Administrative Core is responsible for leadership and management of the Genetics and Genomics of Leiomyosarcoma (LMS): Improved understanding of cancer biology and new approaches to diagnosis and treatment SPORE. The leadership of this Core addresses challenges and opportunities arising in the SPORE weekly webinars, in-person group meetings and ongoing progress reports. The aim is to ensure Project co- leaders and their investigators are making progress in achieving their aims and that the Cores are providing the needed support to ensure overall translational goals are achieved. The Administrative Core will oversee the Career Enhancement (CEP) and Developmental Research (DRP) Programs, by establishing expectations and helping overcome challenges, such that these programs fulfill their vital missions to implement effective plans to recruit early career investigators and identify promising, innovative developmental projects. Core leadership will be responsible for coordinating the External Advisory Board (EAB) meetings and calls as needed to ensure the EAB is kept informed of progress as well as any challenges requiring their advice. Leiomyosarcoma (LMS) provides an ideal opportunity for a collaborative SPORE program that brings together exceptional laboratory and clinical translational scientists with the collective goal of better understanding leiomyosarcoma and improving treatment. This work will have broader relevance to other sarcoma sub-types including undifferentiated pleomorphic sarcoma and osteosarcoma. The team assembled for this grant has been working together on LMS focused research with philanthropic support for the past 3 years. The Principal Investigators and Core Co-Director have worked together over the past 18+ years on collaborative research projects at the University of Michigan and within an academic research consortium. As leaders in the research consortium, Dr. Baker, Dr. Schuetze and Ms. Reinke have the skills and understanding of what is needed to bring a multi-institutional team together and facilitate collaborative research successfully. The leadership team will be administratively supported by the grant management infrastructure at the University of Michigan Medical School which effectively manages NIH grant funding not only at the University but across collaborative academic institutions, a structure aligned with the organization of this grant. The SPORE investigators are aware of the challenges, resource requirements and potential pitfalls relevant to the conduct of this collaborative research and these challenges are mitigated by engaging the well-established collaborative infrastructure of this team. We have created a flexible, highly interactive Administrative Core whereby research plans are collaboratively developed, progress is rigorously monitored, and adjustments are rapidly implemented so as to realize the SPORE goals of improved sarcoma patient care and outcomes.

核心A-行政核心：项目摘要 /摘要行政核心负责对遗传学和基因组学的领导和管理平滑肌肉瘤（LMS）：改善对癌症生物学的理解以及诊断的新方法治疗孢子。该核心的领导解决了孢子中产生的挑战和机遇每周网络研讨会，面对面小组会议和持续的进度报告。目的是确保项目共同领导者及其调查人员正在取得进步，以实现自己的目标，核心正在提供所需的支持以确保实现总体翻译目标。行政核心将监督通过建立期望和帮助克服挑战，使这些计划履行其重要任务以执行有效计划以招募早期职业调查人员并确定有希望的创新发展项目。核心领导会负责协调外部顾问委员会（EAB）会议和电话，以确保 EAB被告知进步以及需要他们建议的任何挑战。 Leomomyosarcoma（LMS）为合作孢子计划提供了理想的机会，该计划将杰出的实验室和临床转化科学家的集体目标是更好地理解平滑肌肉瘤和改善治疗。这项工作将与其他肉瘤子类型具有更广泛的相关性包括未分化的多形性肉瘤和骨肉瘤。为此赠款组成的团队已经在过去的三年中，以慈善支持为以LMS为重点研究。校长在过去的18年以上的协作研究中，调查人员和核心联合导演共同努力密歇根大学和一个学术研究联盟的项目。作为研究的领导者财团，贝克博士，舒特兹博士和雷恩女士都有对需要什么的技能和理解将一个多机构的团队聚集在一起，并成功地促进了协作研究。领导团队密歇根大学医学的赠款管理基础设施将在行政上支持不仅在大学，而且在协作学术中，有效地管理NIH赠款资金的学校机构，与该赠款组织一致的结构。孢子调查人员知道与这项合作研究的行为以及这些挑战通过参与良好的公认来缓解该团队的协作基础架构。我们创建了一个灵活的，高度互动的管理核心研究计划是合作制定的，进度受到严格监控，调整是迅速实施，以实现改善肉瘤患者护理和结果的孢子目标。