PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)

PASSCODE（胰腺腺癌基质重编程联盟协调、数据管理和教育）

• 批准号: 10705730
• 负责人: J. Jack LEE
• 金额: $ 97.2万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705730
• 关键词: American; American Cancer Society; Area; Basic Science; Bioinformatics; Biological Assay; Biometry; Cancer Biology; Cancer Etiology; Cataloging; Cells; Clinical; Clinical Trials Design; Cloud Computing; Collaborations; Communication; Communities; Computational Biology; Cues; Data; Data Collection; Data Coordinating Center; Data Science; Data Storage and Retrieval; Dedications; Desmoplastic; Diagnosis; Disease; Disease Outcome; Ecosystem; Education; Education and Outreach; Educational Activities; Educational workshop; Elements; Ensure; Extracellular Matrix; Fibroblasts; Funding; Genetic; Goals; Group Meetings; Growth; Heterogeneity; Immune; Infrastructure; Intranet; Lymphovascular; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Mission; Molecular; Outcome; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patients; Persons; Policies; Procedures; Reagent; Registries; Regulation; Research; Research Activity; Research Personnel; Role; Secure; Site; Site Visit; Solid; Specificity; Stromal Neoplasm; System; Therapeutic; Time; Tissues; Transfer Agreement; Translational Research; Tumor Promotion; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; analytical tool; biobank; cancer genetics; computing resources; data dissemination; data exchange; data harmonization; data management; improved; innovation; material transfer agreement; meetings; member; microbiome; minority trainee; molecular pathology; mortality; multidisciplinary; multimodal data; neoplastic cell; pancreas visualization; pancreatic tumorigenesis; programs; research study; response; shared database; social media; success; survival outcome; symposium; tumor; tumor immunology; tumor microenvironment; virtual; web site; working group; American; American Cancer Society; Area; Basic Science; Bioinformatics; Biological Assay; Biometry; Cancer Biology; Cancer Etiology; Cataloging; Cells; Clinical; Clinical Trials Design; Cloud Computing; Collaborations; Communication; Communities; Computational Biology; Cues; Data; Data Collection; Data Coordinating Center; Data Science; Data Storage and Retrieval; Dedications; Desmoplastic; Diagnosis; Disease; Disease Outcome; Ecosystem; Education; Education and Outreach; Educational Activities; Educational workshop; Elements; Ensure; Extracellular Matrix; Fibroblasts; Funding; Genetic; Goals; Group Meetings; Growth; Heterogeneity; Immune; Infrastructure; Intranet; Lymphovascular; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Mission; Molecular; Outcome; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patients; Persons; Policies; Procedures; Reagent; Registries; Regulation; Research; Research Activity; Research Personnel; Role; Secure; Site; Site Visit; Solid; Specificity; Stromal Neoplasm; System; Therapeutic; Time; Tissues; Transfer Agreement; Translational Research; Tumor Promotion; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; analytical tool; biobank; cancer genetics; computing resources; data dissemination; data exchange; data harmonization; data management; improved; innovation; material transfer agreement; meetings; member; microbiome; minority trainee; molecular pathology; mortality; multidisciplinary; multimodal data; neoplastic cell; pancreas visualization; pancreatic tumorigenesis; programs; research study; response; shared database; social media; success; survival outcome; symposium; tumor; tumor immunology; tumor microenvironment; virtual; web site; working group

ABSTRACT A defining feature of Pancreatic ductal adenocarcinoma (PDAC) is the presence of a host stromal response, which is characteristically more robust (“desmoplastic”) than many solid cancers. Stromal elements, including cancer-associated fibroblasts (CAFs) and the extracellular matrix, are pivotal components of the tumor microenvironment (TME) ecosystem in PDAC, which also includes immune cells, the lymphovascular system, and the intra-tumoral microbiome. In recent years the role of the PDAC stroma (and CAFs, in particular) has morphed to one characterized by profound heterogeneity, plasticity, and context-specificity. The newly created Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) will fund a team of six U01 sites to conduct basic and translational research studies on the role of the stroma and other TME constituents in PDAC pathogenesis and outcomes. We have collated a multidisciplinary team of investigators at UT MD Anderson with the goal of creating PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education Center), that will serve as an organizing “hub” for coordination, communication and collaboration within the PSRC, and support the newly funded U01 sites. PASSCODE will be co-led by Dr. Anirban Maitra, an expert in PDAC pathology, genetics, and cancer biology, and Dr. J. Jack Lee, an expert in biostatistics, clinical trial design and data science. PASSCODE proposes four aims: First, we will support the administrative infrastructure of the PSRC, and ensure effective communication and collaboration between consortium investigators, the NCI program office and other trans-NCI networks, including facilitating all of the PSRC-approved in-person and virtual meetings. We will also provide operational support for material and data transfer agreements that are germane to the collaborative studies within the PSRC. Second, we will develop a framework for a PSRC “virtual biorepository” as a registry database for shared biospecimen access across the consortium, and develop SOPs for processing, storage, cataloging, and distribution of annotated biospecimens and de-identified clinical, demographic, and molecular information. Third, we will provide centralized data management and data storage capabilities for the PSRC, with the overarching goal of data harmonization and dissemination, within and beyond the consortium. As part of this aim, PASSCODE will provide dedicated biostatistical and bioinformatics analytical tools, and multimodal data visualization for PSRC investigators, including for approved collaborative projects. Fourth, PASSCODE will be responsible for developing and maintaining both a “public facing” PSRC website and other social media outlets, as well as a secure intranet site. We will organize seminars and workshops that highlight progress within the PSRC, and provide a platform for educational/mentorship opportunities, especially with regards to enhancing the participation of underrepresented minority trainees. Cumulatively, PASSCODE’s activities will be geared towards ensuring the success of the consortium’s mission of improving PDAC survival through innovative and collaborative research endeavors.

抽象的 胰腺导管腺癌（PDAC）的定义特征是宿主基质反应的存在， 与许多固体癌症相比，这在特征上更健壮（“去塑料”）。基质元素，包括 癌症相关的成纤维细胞（CAF）和细胞外基质是肿瘤的关键成分 PDAC中的微环境（TME）生态系统，其中还包括免疫细胞，淋巴系统， 和肿瘤内微生物组。近年来，PDAC基质的作用（尤其是CAF）具有 以深刻的异质性，可塑性和背景特异性为特征。新创建的 胰腺癌基质重编程联盟（PSRC）将资助由六个U01站点组成的团队 基础和翻译的研究研究基质和其他TME在PDAC中构成的作用 发病机理和结果。我们已经合作了UT MD Anderson的一个跨学科调查员团队 创建密码（胰腺腺癌基质重编程联盟的目的 协调，数据管理和教育中心），将作为组织“枢纽”的协调， PSRC内的沟通与协作，并支持新资助的U01站点。密码将是 PDAC病理学，遗传学和癌症生物学专家Anirban Maitra博士和J. Jack Lee博士的专家 生物统计学，临床试验设计和数据科学专家。密码提案四个目标：首先，我们将 支持PSRC的管理基础架构，并确保有效的沟通和协作 在财团调查员，NCI计划办公室和其他Trans-NCI网络之间，包括支持所有人 由PSRC批准的面对面和虚拟会议。我们还将为材料提供运营支持和 对PSRC内的协作研究的数据传输协议。第二，我们将发展 PSRC“ Virtual BioreSository”作为注册表数据库的框架 财团以及开发用于加工，存储，分类和分布的SPOPS的SOP 以及取消识别的临床，人口统计和分子信息。第三，我们将提供集中数据 PSRC的管理和数据存储功能，具有数据协调的总体目标 传播，在财团内外。作为此目标的一部分，密码将提供专用 生物统计和生物信息学分析工具，以及PSRC研究者的多模式数据可视化， 包括用于批准的协作项目。第四，密码将负责开发和 维护“公开面对”的PSRC网站和其他社交媒体，以及安全的Intranet网站。 我们将组织的半手和研讨​​会，以突出PSRC内的进展，并为 教育/指导机会，尤其是在加强人数不足的参与方面 少数派学员。累积地，密码的活动将旨在确保 财团的使命是通过创新和协作研究的努力来改善PDAC生存。