A Career Development Award in Global Postpartum Health

全球产后健康职业发展奖

• 批准号: 10706338
• 负责人: Mae Bridget Spelke
• 金额: $ 18.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706338
• 关键词: Adherence; Administrator; Adoption; Africa South of the Sahara; African; Agreement; Area; Attention; Blood Pressure; Characteristics; Child; Childbirth; Clinical Research; Clinical Trials; Clinical Trials Design; Cohort Studies; Country; Data; Discipline of obstetrics; Education; Eligibility Determination; Ensure; Epidemiology; Equity; Evaluation; Family; Fogarty International Center; Foundations; Frequencies; Future; Goals; Gynecologist; Health; Health Services Accessibility; Health Technology; Heart Rate; Hemorrhage; Home; Hospitals; Hour; Hypertension; Income; Infant; International; Intervention; Intervention Trial; Investigation; K-Series Research Career Programs; Learning; Life; Maintenance; Maternal Health; Maternal Mortality; Maternal-fetal medicine; Measures; Medical Records; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Modification; Monitor; Morbidity - disease rate; North Carolina; Outcome; Oxygen; Participant; Patient Monitoring System; Patients; Physiologic Monitoring; Physiologic pulse; Physiological; Policy Maker; Population; Postpartum Period; Postpartum Programs; Postpartum Women; Pregnancy; Pregnant Women; Premature Birth; Prevention; Procedures; Prospective cohort; Protocols documentation; Provider; Proxy; Qualifying; Qualitative Evaluations; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recommendation; Research; Research Personnel; Resource-limited setting; Resources; Risk; Risk Factors; Sample Size; Sepsis; Series; Solid; System; Technology; Temperature; Time; Training; Universities; Woman; Women' s Health; Zambia; adverse birth outcomes; antenatal; blood pressure control; care delivery; care outcomes; career; career development; clinical epidemiology; clinical phenotype; clinical trial implementation; cohort; design; digital; digital health; effectiveness/implementation trial; experience; feasibility trial; follow-up; future implementation; global health; health application; high risk; hospital readmission; implementation framework; implementation research; implementation science; improved; improved outcome; intrapartum; lifetime risk; maternal morbidity; monitoring device; neglect; novel strategies; obstetric outcomes; post implementation; postpartum care; postpartum complications; postpartum health; postpartum outcome; prevent; programs; randomized trial; remote monitoring; respiratory; sensor; severe maternal morbidity; skills; uptake; wearable sensor technology; wireless sensor

ABSTRACT A Career Development Award in Global Postpartum Health This application is for a Fogarty International Center K01 International Research Scientist Development Award (IRSDA) for Dr. Bridget Spelke, MD, an obstetrician-gynecologist and research fellow in Global Women's Health at the University of North Carolina (UNC). Dr. Spelke is in the formative stages of her research career and aims to establish herself as an independent investigator and future leader in the area of global postpartum health, a high-risk period that has been neglected for too long. She has lived full-time in Lusaka, Zambia since August 2019 where she has established a solid career foundation for clinical research in obstetric outcomes for women in resource-constrained settings. Dr. Spelke's proposed K01 research will leverage a recent expansion of the Zambian Preterm Birth Prevention Study (ZAPPS), a long-standing pregnancy cohort that is following women and their infants through 12 months postpartum. Dr. Spelke will study a novel strategy to identify women at risk for severe maternal morbidity and mortality in the first week after delivery: continuous remote physiologic monitoring with easy-to-use, multiparameter, wearable sensors. To inform the design of a future hybrid effectiveness-implementation trial, Dr. Spelke proposes a mentored research program that will estimate the frequency of severe maternal morbidity in the ZAPPS cohort (Aim 1); implement a pilot randomized feasibility trial of postpartum physiologic monitoring (Aim 2); and evaluate barriers and facilitators to adoption of a digital health intervention in a resource-constrained setting through implementation research frameworks (Aim 3). These three research aims will provide preliminary data toward the design of a future trial. They are interrelated and independent of each other; study results will advance research on digital and postpartum health in resource- constrained settings regardless of outcomes. Each of these studies aligns with individualized career development goals in clinical trials design and analysis, implementation research for digital health technologies, and collaborative global health research partnerships. Dr. Spelke has assembled a highly accomplished and eminently qualified mentorship team comprising: her primary Zambia mentor, Prof. Bellington Vwalika, an expert in clinical trials implementation in sub-Saharan Africa; her primary US mentor, Prof. Elizabeth Stringer, an expert in maternal-fetal medicine and maternal health epidemiology; and her core mentor, Prof. Ben Chi, an expert in implementation science in sub-Saharan Africa. All three mentors have decades of experience in collaborative global health partnerships and extensive experience mentoring early career researchers. The IRSDA will advance Dr. Spelke's skills in each of these fields, supporting both didactic and practice-based learning opportunities, as she establishes her independent area of investigation and progresses towards research independence in global postpartum health.

抽象的 全球产后健康职业发展奖 此申请适用于福格蒂国际中心 K01 国际研究科学家发展奖 (IRSDA) 授予 Bridget Spelke 博士（医学博士），她是妇产科医生和全球妇女健康研究员 在北卡罗来纳大学（UNC）。 Spelke 博士正处于研究生涯和目标的形成阶段 为了使自己成为全球产后健康领域的独立研究者和未来领导者， 被忽视太久的高危期。自八月以来，她一直住在赞比亚卢萨卡 2019 年，她为女性产科结果的临床研究奠定了坚实的职业基础 在资源有限的环境中。 Spelke 博士提议的 K01 研究将利用最近的扩展 赞比亚早产预防研究 (ZAPPS)，一项跟踪女性的长期妊娠队列 以及产后 12 个月内的婴儿。斯佩尔克博士将研究一种新策略来识别处于危险中的女性 对于产后第一周严重的孕产妇发病率和死亡率：持续远程生理学 使用易于使用的多参数可穿戴传感器进行监测。为未来混合动力的设计提供信息 在有效性实施试验中，Spelke 博士提出了一项指导研究计划，该计划将估计 ZAPPS 队列中严重孕产妇发病的频率（目标 1）；实施试点随机可行性 产后生理监测试验（目标 2）；并评估采用数字化的障碍和促进因素 通过实施研究框架在资源有限的环境中进行健康干预（目标 3）。 这三个研究目标将为未来试验的设计提供初步数据。它们是相互关联的 并且相互独立；研究结果将推进资源领域的数字和产后健康研究 无论结果如何，都受到限制的设置。这些研究中的每一项都与个性化职业相一致 临床试验设计和分析的发展目标，数字健康技术的实施研究， 以及全球卫生研究合作伙伴关系。 Spelke 博士汇集了一位卓有成就且 优秀的导师团队包括：她的主要赞比亚导师、专家 Bellington Vwalika 教授 在撒哈拉以南非洲实施临床试验；她在美国的主要导师是专家伊丽莎白·斯金格教授 母婴医学和孕产妇健康流行病学；以及她的核心导师Ben Chi教授， 撒哈拉以南非洲的实施科学。三位导师都拥有数十年的合作经验 全球卫生合作伙伴关系和指导早期职业研究人员的丰富经验。 IRSDA 将 提高 Spelke 博士在各个领域的技能，支持教学和基于实践的学习 随着她建立独立的调查领域并在研究方面取得进展，她获得了机会 全球产后健康的独立性。