Developmental Research Program

发展研究计划

• 批准号: 10704559
• 负责人: MARCI LEE NILSEN
• 金额: $ 11.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704559
• 关键词: Annual Reports; Area; Award; Black race; Cancer Center; Cessation of life; Clinical; Clinical Trials; Collaborations; Databases; Development; Early Diagnosis; Electronic Mail; Eligibility Determination; Ensure; Extramural Activities; Feedback; Fostering; Funding; Goals; Grant; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Historically Black Colleges and Universities; Image; Institution; Investments; Legal patent; Link; Mentors; Monitor; Morbidity - disease rate; Organ; Pathology; Patients; Peer Review; Pilot Projects; Prevention; Process; Prognostic Marker; Program Research Project Grants; Publications; Reproduction spores; Research; Research Personnel; Resources; Sampling; Scientist; Sister; Underrepresented Minority; United States National Institutes of Health; Universities; Update; Woman; Work; disability; experience; innovation; inter-institutional; invention; medical schools; meetings; member; mortality; novel; outreach; predictive marker; programs; recruit; skills; stem; therapy resistant; translational impact; tumorigenesis; web site

PROJECT SUMMARY – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Head and Neck (HN) SPORE seeks to fund and facilitate translationally driven, innovative pilot projects in head and neck squamous cell carcinoma (HNSCC). The overarching goal is to decrease HNSCC morbidity and mortality through stimulating new research in the areas of prevention and early detection; mechanisms of tumorigenesis and therapeutic resistance; predictive and prognostic biomarkers; and novel targets and approaches to therapy. To accomplish this goal, we will build on our successful program that, in this current funding cycle, supported 15 awards that subsequently contributed to 42 publications, 9 external grants, 3 patents, 6 inventions and 2 clinical trials, with a return on investment of 27.2 (ie. for every dollar invested 27.2 were returned). Biannually, we will widely solicit proposals from investigators new to HNSCC research as well as from established HNSCC investigators with highly innovative ideas. Members of the Internal and External Advisory Boards will be encouraged to identify investigators outside of the HCC HN SPORE who could serve as potential collaborators. In addition, we have established a partnership with Emory University, Johns Hopkins University, Howard University and Meharry – the latter two designated Historical Black Universities – in an effort to expand the diversity of the applicant pool and be responsive to the most recent SPORE PAR-20-305, with a specific additional DRP award annually for an URM project leader. The most meritorious proposals submitted will be selected based on an NIH-style two-tiered review to ensure rigor and absence of bias and support will come from both SPORE funds and institutional commitment. DRP awardees new to HNSCC will be assigned an experienced mentor to provide guidance and integration into the SPORE. All DRP awardees will report annually on the progress of their projects and those that demonstrate significant research progress will be eligible for competitive renewal for a second year. Should the need arise, exceptional pilots with potential for significant translational impact can be elevated to full SPORE projects. Indeed, two of the three full SPORE projects in this renewal came from DRP pilots.

项目摘要 - 发展研究计划（DRP） UPMC Hillman癌症中心（HCC）头颈的发展研究计划（DRP） （HN）孢子试图资助和促进翻译驱动的，创新的试点项目 鳞状细胞癌（HNSCC）。总体目标是降低HNSCC的发病率和死亡率 通过刺激预防和早期检测领域的新研究；肿瘤发生的机制 和热电阻；预测性和预后生物标志物；以及新颖的目标和方法 治疗。为了实现这一目标，我们将基于我们的成功计划，在当前的资金周期中， 支持了15个奖项，随后为42个出版物，9项外部赠款，3项专利，6个奖项提供了奖项 发明和2项临床试验，投资回报率为27.2（即投资27.2美元 返回）。一年一度，我们将广泛征求HNSCC研究的调查人员的建议以及 来自既定的HNSCC调查人员，具有高度创新的思想。内部和外部成员 鼓励咨询委员会确定可以服务的HCC HN孢子以外的调查员 作为潜在的合作者。此外，我们与埃默里大学（Emory University）建立了合作伙伴关系 大学，霍华德大学和梅哈里（后两名指定历史黑人大学） 努力扩大适用池的多样性，并敏感到最近的孢子20-305， 每年为URM项目负责人获得特定的额外DRP奖。 提交的最有罪的建议将根据NIH风格的两层审查选择，以确保 严格和缺乏偏见和支持将来自孢子资金和机构承诺。 drp HNSCC新手的获奖者将获得一种精神经验，以提供指导和整合到 孢子。所有DRP获奖者每年将报告其项目的进度以及证明的项目的进度 重大的研究进度将有资格获得第二年的竞争续约。如果需要， 具有重大翻译影响潜力的杰出飞行员可以提升为完整的孢子项目。 确实，此续签的三个完整孢子项目中有两个来自DRP飞行员。