Human hippocampal contributions to rapid encoding-retrieval interactions during memory formation

人类海马对记忆形成过程中快速编码-检索相互作用的贡献

• 批准号: 10704012
• 负责人: JOEL L VOSS
• 金额: $ 61.81万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704012
• 关键词: Acceleration; Address; Attention; Automobile Driving; Behavior; Binding; Brain; Brain Injuries; Cognitive; Communication; Coupled; Development; Dorsal; Electric Stimulation; Electrodes; Electroencephalography; Elements; Environment; Epilepsy; Episodic memory; Event; Experimental Designs; Eye Movements; Frequencies; Goals; Grain; Hippocampus; Human; Impairment; Individual; Knowledge; Measures; Memory; Memory Disorders; Memory impairment; Mental disorders; Nerve Degeneration; Neurosurgical Procedures; Pattern; Perception; Phase; Post-Traumatic Stress Disorders; Process; Property; Research; Resolution; Retrieval; Role; Saccades; Sampling; Schizophrenia; Short-Term Memory; Signal Transduction; Stimulus; Technology; Testing; Time; Visual; Visuospatial; clinical care; design; effective therapy; episodic memory impairment; experimental study; improved; indexing; innovation; interest; long term memory; memory encoding; memory process; memory retrieval; millisecond; nervous system disorder; neural; neural correlate; neuromechanism; neurosurgery; neurotransmission; novel; novel strategies; relational memory; sample fixation; spatiotemporal; support network; temporal measurement; visual information; visual learning; visual processing; visual tracking

Project Summary/Abstract Episodic memory impairment is a serious challenge for individuals with neurological and psychiatric disorders that impact the hippocampus, including epilepsy, brain injury, neurodegeneration, schizophrenia, and PTSD. The development of effective treatments will require better understanding of brain mechanisms that support memory formation, storage, and retrieval. The goal of this project is to improve such understanding by testing a hypothesis about the role of the human hippocampus and its interactions with large-scale brain networks in memory formation. Episodic memory formation is a temporally extended process whereby individuals actively sample information in the environment via saccadic eye movements (for visual information), bind this information into an evolving memory representation, and then use this memory representation to inform subsequent viewing of information, and so on. Although the necessary role of the hippocampus in episodic memory formation is well established, little is known regarding how it participates in the extended process of memory formation that occurs during active sampling. This represents a knowledge gap in mechanistic understanding of episodic memory formation, as active sampling is the dominant manner in which memories are created. This project tests the role of the human hippocampus in providing online representation of episodic content and providing the top-down signals to brain networks for visuospatial attention and visual processing needed to drive visual sampling for the formation of coherent episodic memories. This hypothesis will be tested in several experiments that measure and manipulate hippocampal activity within eye-tracking tasks designed to isolate the interplay between memory and visual sampling during memory formation. These experiments will be performed in individuals with epilepsy undergoing neurosurgical procedures as part of clinical care, as this provides invasive recordings of neural activity (iEEG) from the hippocampus and other regions of interest with temporal resolution that matches the rapid pace of eye movements. The temporal resolution of iEEG is key to addressing the hypotheses concerning how the hippocampus drives visual sampling, in addition to responding to it. Direct electrical stimulation through the iEEG electrodes will also be used to test the necessary role of hippocampal processing in driving active visual sampling. By rigorously testing the role of hippocampus in interaction with large-scale networks during the process of memory formation that occurs via active sampling, this project aims to better understand mechanisms relevant to the disruptions of memory formation that occur in neurological and psychiatric disorders. These findings could inform technological approaches to treat memory disorders.

项目摘要/摘要 对于患有神经和精神疾病的人来说，情节记忆障碍是一个严重的挑战 这会影响海马，包括癫痫，脑损伤，神经退行性，精神分裂症和PTSD。 有效治疗的发展将需要更好地了解支持的大脑机制 内存形成，存储和检索。该项目的目的是通过测试 关于人海马的作用及其与大规模脑网络的相互作用的假设 内存形成。情节记忆形成是一个时间扩展的过程 通过SACCADIC眼动物在环境中的示例信息（有关视觉信息），将其绑定 信息到不断发展的内存表示形式，然后使用此内存表示形式告知 随后查看信息，依此类推。虽然海马在情节中的必要作用 记忆形成已经建立得很好，关于它如何参与扩展过程的知之甚少 活跃采样期间发生的记忆形成。这代表了机械的知识差距 理解情节记忆形成，因为主动采样是记忆的主要方式 被创建。该项目测试了人类海马在提供在线表示的作用 情节内容并为大脑网络提供自上而下的信号，以吸引视觉空间的关注和视觉 为了形成相干的情节记忆，需要进行视觉采样所需的处理。这个假设 将在几个实验中测试，以测量和操纵眼睛追踪的海马活动 旨在隔离内存形成过程中内存和视觉采样之间相互作用的任务。这些 将在接受神经外科手术的个体中进行实验 临床护理，因为这提供了来自海马和其他的神经活动（IEEG）的侵入性记录 感兴趣的区域与时间分辨率相匹配，与眼睛运动的快速速度相匹配。时间 IEEG的分辨率是解决有关海马如何驱动视觉的假设的关键 采样，除了回应它。通过IEEG电极的直接电刺激也将是 用于测试海马加工在驱动主动视觉采样中的必要作用。严格地 测试海马在内存过程中与大规模网络相互作用的作用 通过主动抽样发生的形成，该项目旨在更好地了解与该项目相关的机制 神经和精神疾病中发生记忆形成的破坏。这些发现可以 为治疗记忆障碍的技术方法提供信息。