Iron Based Coupling Media (IBCM) for MRI-guided Transcranial Ultrasound Surgeries

用于 MRI 引导经颅超声手术的铁基耦合介质 (IBCM)

基本信息

批准号：
10704562
负责人：
Steven P Allen
金额：
$ 46.28万
依托单位：
BRIGHAM YOUNG UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10704562
关键词：
Acceleration Acoustics Affect Alzheimer&apos s Disease Bathing Blood coagulation Brain region Cephalic Chemistry Clinical Compensation Coupling Development Disease Engineering Epilepsy Essential Tremor FDA approved Feedback Focused Ultrasound Future Gases Glioblastoma Heating Image Imaging Techniques Impairment Individual Iron Liquid substance Literature MRI Scans Magnetic Resonance Magnetic Resonance Imaging Malignant neoplasm of brain Measures Memory Disorders Mental disorders Methods Modality Morbidity - disease rate Morphologic artifacts Motion Movement Disorders Neurologic Operative Surgical Procedures Parkinson Disease Patients Play Process Property Reporting Research Role Science Signal Transduction Societies Surface Suspensions Techniques Technology Temperature Testing Time Tissues Transducers Translations Treatment Efficacy Tremor Unconscious State Water Work aqueous biomaterial compatibility blood-brain barrier disruption clinical translation decay acceleration design experience fluid flow human subject image guided immunoregulation improved improved outcome iron oxide nanoparticle malformation minimally invasive nanoparticle nervous system disorder neuroregulation novel particle sound transmission process tumor ultrasound vibration

项目摘要

Project Summary/Abstract Fatal or impairing neurological diseases, including movement disorders, brain cancers, psychological disorders, epilepsies, malformations, and memory disorders, impose heavy burdens on both individuals and society at large. Transcranial magnetic resonance guided focused ultrasound surgery (tMRgFUS) is an extremely promising, minimally invasive treatment modality for neurological diseases whereby sound waves are focused to a specific region of the brain. Because it is noninvasive, the efficacy of tMRgFUS procedure heavily relies on the accuracy and information content of the guidance technology. This study proposes to improve the treatment efficacy of nearly all tMRgFUS surgeries by eliminating a ubiquitous impediment to accurate and information-rich guidance MRI: the acoustic coupling medium. Interactions between the coupling media and guidance imaging impede tMRgFUS efficacy and translation. For example, while FDA-approved tMRgFUS treatments for essential tremor and Parkinson’s disease can rely on real-time patient feedback to compensate for errors in guidance MR imaging, other tMRgFUS indications cannot access patient feedback because either the patient is unconscious, or the consequences of treatment errors appear only days later. In these cases, guidance imaging errors imposed by the coupling bath cannot be compensated and degrade treatment efficacy To meet this need, our study proposes a dilute, iron-based coupling media (IBCM) that will eliminate coupling- media-induced errors in MRI guidance imaging while maintaining the coupling and cooling functionality critical to acoustic transmission. The specific aims of the study are as follows. Aim 1: Develop novel surface–modified iron oxide nanoparticles for an IBCM. Dilute, aqueous, surface- modified iron oxide nanoparticles can accelerate MRI signal decay such that, during image acquisition, a coupling medium will contribute negligible effects to guidance imaging. However, aqueous nanoparticles also agglomerate and seed treatment-impeding cavitation nucleation in the prefocal acoustic field. This aim will develop novel surface-modified particles that, upon suspension, accelerate MRI signal decay without promoting prefocal nucleation. Aim 2: Investigate the effects of IBCM suspension fluid properties on cavitation nucleation. Fluid properties play a critical role in particle suspension, acoustic coupling, subject cooling, and cavitation nucleation. This aim will investigate cavitation nucleation within the IBCM and how suspension fluid properties, such as pH, temperature, gas content, and flow state, can modify or suppress the nucleation process while maintaining suspension, coupling, and cooling capabilities. Aim 3: Enhance MRI guidance for tMRgFUS through the use of an IBCM. This aim will quantify the value of the IBCM designed in Aims 1 and 2 for tMRgFUS by measuring image quality metrics derived from guidance MRI scans of human subjects. This aim will also develop novel MRI guidance techniques that were previously rendered impossible due to severe image corruptions imposed by the acoustic coupling medium. The resulting IBCM will improve image quality for nearly all guidance techniques employed during, or undergoing development for, tMRgFUS, by rendering the acoustic coupling medium invisible to the MRI scanner without sacrificing necessary acoustic coupling and cooling functionality.

项目概要/摘要致命或损害性神经系统疾病，包括运动障碍、脑癌、心理疾病疾病、癫痫、畸形和记忆障碍给个人和家庭带来沉重的负担经颅磁共振引导聚焦超声手术（tMRgFUS）是一种非常有前途的神经系统疾病微创治疗方式，从而声波由于 tMRgFUS 手术是非侵入性的，因此其功效集中于大脑的特定区域。很大程度上依赖于制导技术的准确性和信息内容。这项研究提出通过消除一个 tMRgFUS 手术来提高几乎所有 tMRgFUS 手术的治疗效果精确且信息丰富的 MRI 引导的普遍障碍：声耦合介质。耦合介质和引导成像之间的相互作用阻碍了 tMRgFUS 的功效和翻译。例如，虽然 FDA 批准的 tMRgFUS 治疗原发性震颤和帕金森病的方法可以依赖实时患者反馈以补偿引导 MR 成像中的错误，其他 tMRgFUS 适应症无法获取患者反馈，因为患者失去知觉，或者治疗错误的后果在这些情况下，耦合浴造成的引导成像误差仅在几天后出现。补偿和降低的治疗效果为了满足这一需求，我们的研究提出了一种稀释的铁基耦合介质（IBCM），它将消除耦合- MRI 引导成像中介质引起的错误，同时保持耦合和冷却功能至关重要声学传输的具体研究目的如下。目标 1：开发用于 IBCM 的新型表面改性氧化铁纳米颗粒。改性氧化铁纳米粒子可以加速 MRI 信号衰减，使得在图像采集过程中，然而，耦合介质对引导成像的影响可以忽略不计。这一目标将在焦前声场中阻止团聚和种子处理的空化成核。开发新型表面改性颗粒，悬浮后可加速 MRI 信号衰减，而无需促进焦前成核。目标 2：研究 IBCM 悬浮液特性对空化成核的影响。特性在颗粒悬浮、声耦合、主体冷却和空化中发挥着关键作用该目标将研究 IBCM 内的空化成核以及悬浮液的特性，例如 pH、温度、气体含量和流动状态，可以改变或抑制成核过程，同时保持悬挂、耦合和冷却能力。目标 3：通过使用 IBCM 增强 MRI 对 tMRgFUS 的指导该目标将量化其价值。通过测量从指导中得出的图像质量指标，实现目标 1 和 2 中为 tMRgFUS 设计的 IBCM 这一目标还将开发以前的新型 MRI 引导技术。由于声耦合介质造成的严重图像损坏而变得不可能。由此产生的 IBCM 将提高几乎所有在飞行过程中或正在进行中使用的制导技术的图像质量。 tMRgFUS 的开发，通过使 MRI 扫描仪不可见声耦合介质而无需牺牲必要的声耦合和冷却功能。