Iron Based Coupling Media (IBCM) for MRI-guided Transcranial Ultrasound Surgeries

用于 MRI 引导经颅超声手术的铁基耦合介质 (IBCM)

• 批准号: 10704562
• 负责人: Steven P Allen
• 金额: $ 46.28万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704562
• 关键词: Acceleration; Acoustics; Affect; Alzheimer' s Disease; Bathing; Blood coagulation; Brain region; Cephalic; Chemistry; Clinical; Compensation; Coupling; Development; Disease; Engineering; Epilepsy; Essential Tremor; FDA approved; Feedback; Focused Ultrasound; Future; Gases; Glioblastoma; Heating; Image; Imaging Techniques; Impairment; Individual; Iron; Liquid substance; Literature; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Malignant neoplasm of brain; Measures; Memory Disorders; Mental disorders; Methods; Modality; Morbidity - disease rate; Morphologic artifacts; Motion; Movement Disorders; Neurologic; Operative Surgical Procedures; Parkinson Disease; Patients; Play; Process; Property; Reporting; Research; Role; Science; Signal Transduction; Societies; Surface; Suspensions; Techniques; Technology; Temperature; Testing; Time; Tissues; Transducers; Translations; Treatment Efficacy; Tremor; Unconscious State; Water; Work; aqueous; biomaterial compatibility; blood-brain barrier disruption; clinical translation; decay acceleration; design; experience; fluid flow; human subject; image guided; immunoregulation; improved; improved outcome; iron oxide nanoparticle; malformation; minimally invasive; nanoparticle; nervous system disorder; neuroregulation; novel; particle; sound; transmission process; tumor; ultrasound; vibration

Project Summary/Abstract Fatal or impairing neurological diseases, including movement disorders, brain cancers, psychological disorders, epilepsies, malformations, and memory disorders, impose heavy burdens on both individuals and society at large. Transcranial magnetic resonance guided focused ultrasound surgery (tMRgFUS) is an extremely promising, minimally invasive treatment modality for neurological diseases whereby sound waves are focused to a specific region of the brain. Because it is noninvasive, the efficacy of tMRgFUS procedure heavily relies on the accuracy and information content of the guidance technology. This study proposes to improve the treatment efficacy of nearly all tMRgFUS surgeries by eliminating a ubiquitous impediment to accurate and information-rich guidance MRI: the acoustic coupling medium. Interactions between the coupling media and guidance imaging impede tMRgFUS efficacy and translation. For example, while FDA-approved tMRgFUS treatments for essential tremor and Parkinson’s disease can rely on real-time patient feedback to compensate for errors in guidance MR imaging, other tMRgFUS indications cannot access patient feedback because either the patient is unconscious, or the consequences of treatment errors appear only days later. In these cases, guidance imaging errors imposed by the coupling bath cannot be compensated and degrade treatment efficacy To meet this need, our study proposes a dilute, iron-based coupling media (IBCM) that will eliminate coupling- media-induced errors in MRI guidance imaging while maintaining the coupling and cooling functionality critical to acoustic transmission. The specific aims of the study are as follows. Aim 1: Develop novel surface–modified iron oxide nanoparticles for an IBCM. Dilute, aqueous, surface- modified iron oxide nanoparticles can accelerate MRI signal decay such that, during image acquisition, a coupling medium will contribute negligible effects to guidance imaging. However, aqueous nanoparticles also agglomerate and seed treatment-impeding cavitation nucleation in the prefocal acoustic field. This aim will develop novel surface-modified particles that, upon suspension, accelerate MRI signal decay without promoting prefocal nucleation. Aim 2: Investigate the effects of IBCM suspension fluid properties on cavitation nucleation. Fluid properties play a critical role in particle suspension, acoustic coupling, subject cooling, and cavitation nucleation. This aim will investigate cavitation nucleation within the IBCM and how suspension fluid properties, such as pH, temperature, gas content, and flow state, can modify or suppress the nucleation process while maintaining suspension, coupling, and cooling capabilities. Aim 3: Enhance MRI guidance for tMRgFUS through the use of an IBCM. This aim will quantify the value of the IBCM designed in Aims 1 and 2 for tMRgFUS by measuring image quality metrics derived from guidance MRI scans of human subjects. This aim will also develop novel MRI guidance techniques that were previously rendered impossible due to severe image corruptions imposed by the acoustic coupling medium. The resulting IBCM will improve image quality for nearly all guidance techniques employed during, or undergoing development for, tMRgFUS, by rendering the acoustic coupling medium invisible to the MRI scanner without sacrificing necessary acoustic coupling and cooling functionality.

项目摘要/摘要 致命或损害神经系统疾病，包括运动障碍，脑癌，心理 疾病，癫痫，畸形和记忆障碍，对两个人施加沉重的伯伦斯 整个社会。经颅磁共振引导聚焦超声手术（TMRGFUS）是 对神经疾病的极为有希望的，微创的治疗方式，声波 专注于大脑的特定区域。因为它是无创的，所以TMRGFUS程序的效率 在很大程度上依赖于指导技术的准确性和信息内容。 这项研究提出的建议，通过消除A 无处不在的障碍对准确且信息丰富的指导MRI：声学耦合介质。 耦合介质和指导成像之间的相互作用阻碍了TMRGFUS效率和翻译。为了 例如，尽管FDA批准的TMRGFU治疗可用于基本震颤和帕金森氏病 实时的患者反馈以弥补指导MR成像中错误的错误，其他TMRGFUS迹象不能 访问患者的反馈，因为患者失去知觉或治疗错误的后果 仅几天后出现。在这些情况下，耦合浴犯施加的指导成像错误不能 补偿和降低治疗效率 为了满足这一需求，我们的研究提出了一种稀释的，基于铁的耦合介质（IBCM），将消除耦合 - 媒体引起的MRI指导成像中的错误，同时保持耦合和冷却功能至关重要 到声传播。该研究的具体目的如下。 目标1：为IBCM开发新型的表面氧化铁纳米颗粒。稀释，水性，表面 修饰的氧化铁纳米颗粒可以加速MRI信号衰减，以便在图像采集期间 耦合培养基将对指导成像产生可忽略的影响。但是，水纳米颗粒也 聚集的和种子治疗的雾化的空化成核中的焦点域中。这个目标 开发新型的表面修饰颗粒，在悬浮后加速MRI信号衰减而无需 促进邻核成核。 目标2：研究IBCM悬浮液特性对空化成核的影响。体液 特性在粒子悬浮液，声耦合，受试者冷却和气蚀中起关键作用 成核。该目标将研究IBCM内的气核以及悬浮液特性如何， 例如pH，温度，气体含量和流量状态，可以修改或抑制成核过程，而 保持悬架，耦合和冷却能力。 AIM 3：通过使用IBCM来增强TMRGFU的MRI指南。这个目标将量化价值 通过测量从指导而得出的图像质量指标，在目标1和2中设计的IBCM 人类受试者的MRI扫描。这个目标还将开发以前的新型MRI指导技术 由于声学耦合介质造成的严重图像损坏，因此变得不可能。 由此产生的IBCM将改善几乎所有指导技术或正在进行的指导技术的图像质量 通过呈现MRI扫描仪的声学耦合培养基，开发TMRGFU 牺牲必要的声学耦合和冷却功能。