High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography

基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块，用于长轴视场正电子发射断层扫描

• 批准号: 10689100
• 负责人: Sun Il Kwon
• 金额: $ 55.61万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689100
• 关键词: Animals; Binding; Biomedical Research; Ceramics; Clinical; Compensation; Detection; Diagnostic; Goals; Head; Healthcare; Human; Imaging Techniques; Lanthanum; Length; Light; Measures; Methods; Optics; Outcome; Pathway interactions; Performance; Positron-Emission Tomography; Price; Production; Property; Radioactivity; Research; Resolution; Sampling; Structure; System; Technology; Thick; Time; Tracer; Visualization; animal imaging; cost; cost comparison; cost effective; cost estimate; density; design; detection sensitivity; detector; fabrication; human imaging; improved; innovation; manufacturing cost; millisecond; molecular diagnostics; molecular imaging; next generation; novel; simulation; tomography; translational medicine; trend; usability

SUMMARY Positron emission tomography (PET) is unrivaled as a highly specific and sensitive means for tomographic imaging of molecular interactions and pathways in humans, offering great utility for translational medicine. Recently, long axial field-of-view PET scanners, which provide excellent geometric coverage, giving much better detection sensitivity, have been developed. However, cost and performance issues are raised as concerns. To resolve both cost and performance issues, next generation long axial field-of-view PET detector modules should employ new scintillators to realize the full performance capabilities of PET at a viable price point. A proposed ceramic scintillator has extremely high stopping power and density, better than any currently used scintillator for PET. The proposed scintillator has a high light yield and an excellent energy resolution. Moreover, we achieved a very good coincidence timing resolution. In addition, it has a cubic crystal structure allowing fabrication by ceramic processing, with potential for a major reduction in cost compared with L(Y)SO. This proposal is 1) to develop the new ceramic scintillator for PET with large volumes and high clarity, 2) to characterize the new scintillator as a PET scintillator, 3) to apply the new scintillator array blocks into well- designed existing PET detector modules to evaluate performance of the new scintillator at the module level, and finally 4) to develop novel time-of-flight (TOF)-PET detector modules by combining the new ceramic scintillator and advanced PET readout methods for next-generation PET scanners. The proposed ceramic scintillator and PET detector modules are not limited to long axial field-of-view PET scanners and will be widely usable. The impact of this proposal is that it provides a pathway to 1) realizing long axial field-of-view scanners with unprecedented sensitivity without a proportional increase in scanner cost and 2) enabling performance advantages in shorter scintillators in terms of reducing DOI effect and improving timing and energy resolution without losing detection efficiency for next-generation TOF-PET scanners.

概括 正电子发射断层扫描（PET）是无与伦比的，是一种高度特异性和敏感的手段 人类分子相互作用和途径的成像，为翻译医学提供了极大的效用。 最近，长轴向视野宠物扫描仪可提供出色的几何覆盖范围，从而使得更好 检测敏感性已经开发出来。但是，成本和绩效问题被提高为担忧。到 解决成本和性能问题，下一代长轴向视野宠物探测器模块应 雇用新的闪光灯以可行的价格实现宠物的全部性能能力。 拟议的陶瓷闪烁体具有极高的停止功率和密度，比目前使用的任何人都要好 宠物的闪光灯。提出的闪光灯具有高光的产量和出色的能量分辨率。而且， 我们实现了一个很好的巧合计时解决方案。此外，它具有一个立方晶体结构，允许 通过陶瓷加工制造，与L（y）So相比，成本大大降低。 该提案是1）开发新的陶瓷闪光器，用于巨大且高清晰度，2） 将新的闪光灯描述为PET闪烁体，3）将新的闪烁体阵列应用于良好 设计了现有的宠物探测器模块，以评估模块级别的新闪烁器的性能，并 最后4）通过组合新的陶瓷闪光灯来开发新型飞行时间（TOF）-PET检测器模块 以及下一代宠物扫描仪的先进宠物读数方法。 提议的陶瓷闪烁体和宠物探测器模块不限于长轴向视野宠物 扫描仪，将被广泛使用。该提议的影响是它提供了通往1）长期实现的途径 轴向视野扫描仪具有前所未有的灵敏度，而扫描仪成本和 2）在降低doi效果方面，较短闪烁器的性能优势 和能量分辨率，而不会失去下一代TOF-PET扫描仪的检测效率。