NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

NeuroDev Kenya：描述肯尼亚海岸发育障碍的流行病学和病因学

基本信息

批准号：
10689789
负责人：
Amina Abubakar
金额：
$ 51.61万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10689789
关键词：
16p11.2 Address Adult Affect Africa African African ancestry Age American Area Attention Deficit Disorder Award Behavioral Bioethics Blood Cell Line Child Chronic Clinical Cognitive Collection Communities DNA Data Data Analyses Data Collection Data Set Enrollment Environment Epidemiology Equity Ethics Etiology Fathers Foundations Funding Genetic Genetic Research Genetic Variation Genetic study Genomics Genotype Grant Guidelines Health Heterogeneity Individual Inequity Infant Mortality Institution Intellectual functioning disability International Kenya Link Measures Medical Medical Genetics Medical Research Mothers Neurodevelopmental Disorder Output Parents Participant Phenotype Pilot Projects Prevalence Protocols documentation Public Health Schools Research Research Institute Research Personnel Resources Risk Rural Site South Africa Structure Testing Training United States National Institutes of Health Work analysis pipeline autism spectrum disorder cohort design developmental disease doctoral student exome sequencing genetic analysis genetic disorder diagnosis genetic resource genome sciences genomic data medical schools neuropsychiatric disorder non-verbal phenotypic data programs rare genetic disorder recruit social tool

项目摘要

Project Summary/Abstract The NeuroDev Kenya data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available. In this application, we propose to conduct extensive analysis of NeuroDev Kenya’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (Aim 3). Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NeuroDev Kenya, and determine how to ethically include adults with ID. We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD Research Network formalized through this award (Aim 4).

项目摘要/摘要 Neurodev肯尼亚数据集将为研究的病因提供前所未有的机会东非的神经发育障碍（NDDS），并创造了国际价值的研究资源。它将是在粗糙的非洲环境中的第一个大规模NDD系列，该系列被深入表型且一般信息丰富，所有数据和材料都将公开可用。在此应用程序中，我们建议对肯尼亚的Neurodev遗传和表型数据进行广泛的分析，始于该奖项第二年。分析将利用Kemri的丰富环境，并将与我们的拟议的能力建设活动（AIM 3）。通过我们的能力建设活动，我们将提供结构化的遗传学和遗传数据分析的培训，确定是否引入淋巴细胞细胞系（LCL）肯尼亚Neurodev的方案，并确定如何在道德上包括具有ID的成年人。我们将共享所有数据（例如表型，基因型）和通过NIH的材料（例如血液中的DNA，可能的LCLS）。我们将还通过国际财团和新的非洲NDD研究网络正式分享产出通过此奖项（目标4）。