The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals

麻省理工学院超级基金研究计划：保护人类健康免受危险化学品侵害的系统方法

基本信息

批准号：
10687973
负责人：
Bevin P. Engelward
金额：
$ 227.62万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2027-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY/ABSTRACT – OVERALL N-Nitrosamines are a family of hazardous chemicals that are among the most mutagenic chemicals known, and many are potently carcinogenic in animal models. People living in Wilmington, MA, are concerned about N- nitrosamines because there are over 20 million gallons of N-nitrosamine-contaminated waste at the nearby Olin Chemical Superfund Site, contaminating the environment and rendering their well water undrinkable. The Passamaquoddy Tribe is also concerned about N-nitrosamines, because their water contains high levels of organic material and the use of chloramine is known to create N-nitrosodimethylamine. Specific Aim 1 is to make and measure. Innovative, light-based chemical sensors that exploit smartphones will be created and used for Citizen Science to gain information that will help to inform cleanup by the Environmental Protection Agency (EPA). Innovative, high-throughput `animate sensors,' based on cell-microarray technology, will be created and used to test the consequences of N-nitrosamines on health-related impacts known to be associated with cancer risk. To understand disease more deeply, a genetically engineered “canary in the coal mine” mouse model will be used to reveal the potential for long-term low-dose exposure to cause mutations and deleterious biological responses. Specific Aim 2 is to protect human health via prediction and prevention of disease. By integrating multi-omics data (fueled by the Data Management and Analysis Core [DMAC]), mechanistic knowledge will propel the development of predictive biomarkers that can be used to develop methods to prevent disease. The potential for probiotics to suppress N-nitrosamine-induced cancer will be studied. In addition, novel devices will be created to destroy N-nitrosamines via electrochemical and biochemical destruction. Importantly, risk evaluation depends on knowledge from both engineers and biologists. The DMAC will thus form a critical integrating role by merging transdisciplinary data streams to evaluate risk for specific water samples. Specific Aim 3 is to maximize societal impact via integration within the MIT SRP and with partners outside of MIT. Partnering with the community will allow collection of environmental data that will inform risk. Via bidirectional communication, community members will also benefit from novel, hands-on teaching kits, while MIT SRP members will benefit from learning about community perspectives and concerns. Dissemination of MIT SRP knowledge and technologies will also be achieved via continued strengthening of relationships between the MIT SRP and local, state, Tribal and governmental agents, including community members who are most impacted by N-nitrosamine contamination. All of this work will be made possible by careful coordination and formalization of translation opportunities (made possible by the Administrative Core), and by continuous improvement of training opportunities that not only fuel the research (made possible by the Research Experience and Training Coordination Core [RETCC]), but also help to ensure that trainees go on to contribute as responsible leaders who are able to leverage cross-disciplinary research in order to have a powerful impact on public health.

项目摘要/摘要 - 总体 N-亚硝胺是一个危险化学物质的家族，是最诱变的化学物质之一，并且许多在动物模型中可能具有致癌性。居住在马萨诸塞州威尔明顿的人们担心n- 硝基胺是因为附近的Olin有超过2000万加仑的N-氮胺污染废物化学超级基金地点，污染环境，使其井水不可饮用。这 Passamaquoddy Tribe也担心N-亚硝基胺，因为它们的水含有高水平已知有机材料和氯胺的使用会产生N-硝基二甲胺。具体目标1是进行和测量。将创建和使用利用智能手机的创新，基于光的化学传感器为了使公民科学获取信息，这些信息将有助于通知环境保护局的清理（EPA）。将创建基于细胞微阵列技术的创新，高通量“动画传感器”，并将创建和用于测试N-亚硝胺对与癌症有关的健康相关影响的后果风险。为了更深入地了解疾病，基因工程的“煤矿中的金丝雀”老鼠模型将用于揭示长期低剂量暴露以引起突变和有害生物学的潜力回答。具体目标2是通过预测和预防疾病来保护人类健康。经过集成多摩斯数据（由数据管理和分析核心[DMAC]促进），机械知识将推动预测生物标志物的开发，可用于开发方法以防止疾病。益生菌抑制N-亚硝胺诱导的癌症的潜力将是研究的。此外，新颖将创建设备，以通过电化学和生化破坏来破坏N-亚硝基胺。重要的是，风险评估取决于工程师和生物学家的知识。因此，DMAC将形成关键通过合并跨学科数据流来评估特定水样本的风险来整合角色。具体的 AIM 3是通过MIT SRP和MIT以外的合作伙伴的整合来最大化社会影响。与社区合作将允许收集将为风险带来的环境数据。通过双向沟通，社区成员还将受益于新颖的动手教学套件，而麻省理工学院SRP 成员将从学习社区观点和关注点中受益。 MIT SRP的传播知识和技术也将通过持续加强麻省理工学院之间的关系来实现 SRP和地方，州，部落和政府代理人，包括受影响最大的社区成员通过N-亚硝基胺污染。通过仔细的协调和格式化，所有这些工作都将成为可能翻译机会（通过行政核心使可能成为可能），并通过不断改进培训机会不仅可以助长研究（通过研究经验和培训使其成为可能协调核心[RETCC]），但也有助于确保培训继续作为负责任的领导者做出贡献能够利用跨学科研究的人，以对公共卫生产生强大的影响。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using the HepaCometChip Assay for Broad-Spectrum DNA Damage Analysis.

DOI：
10.1002/cpz1.563
发表时间：
2022-09
期刊：
Current protocols
影响因子：
0
作者：
Owiti, Norah A;Kaushal, Simran;Martin, Lincoln;Sly, Jamie;Swartz, Carol D;Fowler, Jasmine;Corrigan, Joshua J;Recio, Les;Engelward, Bevin P
通讯作者：
Engelward, Bevin P

A Prototype Sensor for In Situ Sensing of Fine Particulate Matter and Volatile Organic Compounds.

用于细颗粒物和挥发性有机化合物原位传感的原型传感器。