The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals

麻省理工学院超级基金研究计划：保护人类健康免受危险化学品侵害的系统方法

基本信息

批准号：
10687973
负责人：
Bevin P. Engelward
金额：
$ 227.62万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2027-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY/ABSTRACT – OVERALL N-Nitrosamines are a family of hazardous chemicals that are among the most mutagenic chemicals known, and many are potently carcinogenic in animal models. People living in Wilmington, MA, are concerned about N- nitrosamines because there are over 20 million gallons of N-nitrosamine-contaminated waste at the nearby Olin Chemical Superfund Site, contaminating the environment and rendering their well water undrinkable. The Passamaquoddy Tribe is also concerned about N-nitrosamines, because their water contains high levels of organic material and the use of chloramine is known to create N-nitrosodimethylamine. Specific Aim 1 is to make and measure. Innovative, light-based chemical sensors that exploit smartphones will be created and used for Citizen Science to gain information that will help to inform cleanup by the Environmental Protection Agency (EPA). Innovative, high-throughput `animate sensors,' based on cell-microarray technology, will be created and used to test the consequences of N-nitrosamines on health-related impacts known to be associated with cancer risk. To understand disease more deeply, a genetically engineered “canary in the coal mine” mouse model will be used to reveal the potential for long-term low-dose exposure to cause mutations and deleterious biological responses. Specific Aim 2 is to protect human health via prediction and prevention of disease. By integrating multi-omics data (fueled by the Data Management and Analysis Core [DMAC]), mechanistic knowledge will propel the development of predictive biomarkers that can be used to develop methods to prevent disease. The potential for probiotics to suppress N-nitrosamine-induced cancer will be studied. In addition, novel devices will be created to destroy N-nitrosamines via electrochemical and biochemical destruction. Importantly, risk evaluation depends on knowledge from both engineers and biologists. The DMAC will thus form a critical integrating role by merging transdisciplinary data streams to evaluate risk for specific water samples. Specific Aim 3 is to maximize societal impact via integration within the MIT SRP and with partners outside of MIT. Partnering with the community will allow collection of environmental data that will inform risk. Via bidirectional communication, community members will also benefit from novel, hands-on teaching kits, while MIT SRP members will benefit from learning about community perspectives and concerns. Dissemination of MIT SRP knowledge and technologies will also be achieved via continued strengthening of relationships between the MIT SRP and local, state, Tribal and governmental agents, including community members who are most impacted by N-nitrosamine contamination. All of this work will be made possible by careful coordination and formalization of translation opportunities (made possible by the Administrative Core), and by continuous improvement of training opportunities that not only fuel the research (made possible by the Research Experience and Training Coordination Core [RETCC]), but also help to ensure that trainees go on to contribute as responsible leaders who are able to leverage cross-disciplinary research in order to have a powerful impact on public health.

项目概要/摘要——总体 N-亚硝胺是一类危险化学品，是已知最具致突变性的化学品之一，并且许多在动物模型中具有强致癌性，居住在马萨诸塞州威尔明顿的人们担心 N-。亚硝胺，因为附近的奥林有超过 2000 万加仑受 N-亚硝胺污染的废物化学超级基金站点，污染环境并使其井水无法饮用。帕萨马科迪部落也担心 N-亚硝胺，因为他们的水中含有高浓度的 N-亚硝胺。已知使用有机材料和氯胺可产生 N-亚硝基二甲胺。具体目标 1 是将创建和使用利用智能手机的创新型光化学传感器。公民科学获取有助于环境保护局清理工作的信息 (EPA) 将创建和基于细胞微阵列技术的创新、高通量“动画传感器”。用于测试 N-亚硝胺对已知与癌症相关的健康影响的后果为了更深入地了解疾病的风险，基因工程“煤矿里的金丝雀”小鼠模型将被采用。用于揭示长期低剂量暴露导致突变和有害生物学的可能性具体目标 2 是通过预测和预防疾病来保护人类健康。多整合组学数据（由数据管理和分析核心 [DMAC] 推动），机械知识将推动预测生物标志物的开发，这些标志物可用于开发预防方法此外，还将研究益生菌抑制 N-亚硝胺诱发的癌症的潜力。将创建通过电化学和生化破坏来破坏 N-亚硝胺的装置。因此，风险评估取决于工程师和生物学家的知识。通过合并跨学科数据流来评估特定水样的风险来整合角色。目标 3 是通过 MIT SRP 内部以及与 MIT 外部合作伙伴的整合，最大限度地发挥社会影响。与社区合作将允许通过双向收集环境数据来告知风险。沟通，社区成员也将受益于新颖的实践教学套件，而麻省理工学院的 SRP 成员将受益于了解社区观点和关注的麻省理工学院 SRP 的传播。知识和技术也将通过不断加强麻省理工学院之间的关系来实现 SRP 以及地方、州、部落和政府机构，包括受影响最严重的社区成员所有这些工作都将通过仔细协调和正规化来实现。翻译机会（通过行政核心实现），以及通过不断改进培训机会不仅可以推动研究（通过研究经验和培训使之成为可能）协调核心 [RETCC]），还有助于确保学员继续作为负责任的领导者做出贡献他们能够利用跨学科研究对公共卫生产生强大影响。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using the HepaCometChip Assay for Broad-Spectrum DNA Damage Analysis.

DOI：
10.1002/cpz1.563
发表时间：
2022-09
期刊：
Current protocols
影响因子：
0
作者：
Owiti, Norah A;Kaushal, Simran;Martin, Lincoln;Sly, Jamie;Swartz, Carol D;Fowler, Jasmine;Corrigan, Joshua J;Recio, Les;Engelward, Bevin P
通讯作者：
Engelward, Bevin P

Assessing the accuracy of low-cost optical particle sensors using a physics-based approach.