Ambulatory Assessment of Simultaneous Alcohol and Marijuana Use: Impact on Alcohol Use and Consequences

同时使用酒精和大麻的动态评估：对酒精使用的影响和后果

• 批准号: 10687878
• 负责人: Rachel Lyn Gunn
• 金额: $ 18.69万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687878
• 关键词: Acute; Adverse effects; Age; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Area; Behavior; Behavior assessment; Behavioral; Biological; Biosensor; Cannabinoids; Characteristics; Climate; Clinical; Clinical Sciences; Cognitive; Collaborations; Consumption; Data; Data Collection; Development; Disinhibition; Doctor of Philosophy; Environment; Equilibrium; Event; Foundations; Future; Gait; Goals; Heavy Drinking; High Prevalence; Human; Impaired cognition; Impairment; Individual; Intervention; Intoxication; Knowledge; Laboratories; Laboratory Research; Laboratory Study; Legal; Life; Marijuana; Measures; Mentorship; Methodology; Methods; Morbidity - disease rate; Motivation; Outcome; Participant; Patient Self-Report; Pattern; Physiological; Policies; Prevention; Public Health; Recreation; Reporting; Research; Research Activity; Research Personnel; Role; Scientist; Social Change; Statistical Data Interpretation; Technology; Tetrahydrocannabinol; Tobacco; Training; Training Activity; Treatment outcome; United States; Universities; Work; addiction; alcohol abuse therapy; alcohol availability; alcohol behavior; alcohol consequences; alcohol craving; alcohol effect; alcohol misuse; alcohol related consequences; alcohol use disorder; career; contextual factors; craving; design; drinking; experience; high risk; innovation; marijuana legalization; marijuana use; marijuana user; mobile application; mortality; motor impairment; novel; pharmacologic; prospective; skill acquisition; social; social influence; substance use; symptomatology; trait impulsivity; young adult

Project Summary/Abstract Through research and training activities described in this K08 proposal, the PI will acquire the skills necessary to become an independent clinical science researcher in the comprehensive study of alcohol co-use behaviors. Aside from tobacco, alcohol and marijuana are the most commonly used substances nationwide, and the most frequently co-used. With the rapid legalization of marijuana in the United States, it is likely that rates of co-use will continue to rise, particularly among young adults who currently report the highest rates of use. Despite the combined legislative changes and rising public acceptance of marijuana, little is known about how simultaneous use of alcohol and marijuana (SAM) impacts alcohol behaviors. Additionally, necessities of laboratory research (e.g. lower potency marijuana, controlled drinking contexts) present challenges in studying the effects of SAM use. The purpose of the proposed study is to examine whether SAM use leads to increased alcohol consumption and consequences by utilizing ambulatory assessment (AA) methodology. AA involves the integration of assessment methodologies (e.g. self-report, behavioral, physiological) to study individuals in their natural environment. The proposed study would be the first to employ novel behavioral assessments of disinhibition and motor impairment and biological measures of alcohol use (transdermal alcohol concentration: TAC) to study the impact of SAM use on alcohol consumption at the event level and consequences at the daily level. The study involves original data collection from young adult regular alcohol and marijuana users (N=80) who will complete 4 weeks of AA data collection while wearing alcohol biosensors to assess TAC. A combination of self-initiated and random reports of alcohol and marijuana use, subjective intoxication, and craving; paired with behavioral assessment of disinhibition and motor impairment (gait and balance) will be collected. The PI will collaborate with an impressive mentorship team carrying extensive experience in four areas of training: 1) behavioral and pharmacological effects of alcohol and marijuana co-use (Jane Metrik, PhD); 2) ambulatory assessment (Robert Miranda, PhD; Timothy Trull, PhD); 3) alcohol biosensor technology (Nancy Barnett, PhD); and 4) advanced statistical analyses (Kristina Jackson, PhD). The proposed 5-year training plan will prepare the PI for a career as a clinical scientist with expertise in the study of alcohol co-use behaviors; with the ultimate goal of conducting mixed-method designs to capture behavior in controlled laboratory conditions and the natural environment. Research and training will occur at the Center for Alcohol and Addiction Studies (CAAS) at Brown University. CAAS is an interdisciplinary center devoted to research and training in the study of addiction. The proposed research will advance our understanding of mechanisms by which SAM use impacts alcohol use and consequences by building on knowledge gained from controlled laboratory research. Results will inform policy, prevention, and intervention efforts to reduce the negative outcomes associated with simultaneous use of alcohol and marijuana.

项目概要/摘要 通过本 K08 提案中描述的研究和培训活动，PI 将获得必要的技能 成为酒精共同使用行为综合研究的独立临床科学研究人员。 除烟草外，酒精和大麻是全国最常用的物质，也是最常见的物质。 经常共同使用。随着美国大麻的迅速合法化，共同使用率可能会下降 将继续上升，特别是在目前报告使用率最高的年轻人中。尽管 结合立法的变化和公众对大麻接受程度的提高，人们对如何做到这一点知之甚少。 同时使用酒精和大麻 (SAM) 会影响饮酒行为。此外，必需品 实验室研究（例如低效大麻、控制饮酒环境）给研究带来了挑战 SAM 使用的影响。拟议研究的目的是检验 SAM 的使用是否会导致增加 利用流动评估（AA）方法的饮酒量和后果。 AA 涉及 整合评估方法（例如自我报告、行为、生理）来研究个体 他们的自然环境。拟议的研究将是第一个采用新颖的行为评估的研究 去抑制和运动障碍以及酒精使用的生物测量（经皮酒精浓度： TAC）研究 SAM 使用对事件层面酒精消耗的影响以及日常后果 等级。该研究涉及从经常酗酒和吸食大麻的年轻人 (N=80) 收集原始数据 他们将完成 4 周的 AA 数据收集，同时佩戴酒精生物传感器来评估 TAC。一个 结合自发和随机报告的酒精和大麻使用、主观中毒以及 渴望；与去抑制和运动障碍（步态和平衡）的行为评估相结合 集。 PI 将与一个令人印象深刻的指导团队合作，该团队在四个方面拥有丰富的经验 培训领域：1）酒精和大麻共同使用的行为和药理学影响（Jane Metrik， 博士）； 2) 动态评估（罗伯特·米兰达博士；蒂莫西·特鲁尔博士）； 3）酒精生物传感器技术 （南希·巴尼特博士）； 4) 高级统计分析（Kristina Jackson 博士）。拟议的5年 培训计划将为 PI 的职业生涯做好准备，成为具有酒精共同使用研究专业知识的临床科学家 行为；最终目标是进行混合方法设计以捕获受控行为 实验室条件和自然环境。研究和培训将在酒精中心进行 和布朗大学成瘾研究（CAAS）。 CAAS是一个致力于研究的跨学科中心 以及成瘾研究培训。拟议的研究将增进我们对机制的理解 SAM 的使用通过建立从受控酒精中获得的知识来影响酒精的使用和后果 实验室研究。结果将为政策、预防和干预工作提供信息，以减少负面影响 与同时使用酒精和大麻相关的结果。