The Wisconsin State Laboratory of Hygiene?s Proposal to Add to the Capability and

威斯康星州立卫生实验室关于增加能力和

• 批准号: 8696858
• 负责人: MICHAEL Frederick ARNDT
• 金额: $ 25万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696858
• 关键词: Wisconsin; State; Laboratory; Hygiene; Proposal

Project Summary/Abstract The Radiochemistry Unit at the Wisconsin State Laboratory of Hygiene plans on working with the FDA and other FERN laboratories to extend current rapid-screening methods to more food matrices, to develop new rapid-screening methods, and to extend and develop methods to identify specific radionuclides. Some work intensive steps-like wet-ashing and chromatography-require considerable attention by an analyst. It is proposed that these steps be automated to increase the sample preparation rate and to allow analysts to spend more time on other tasks. The Radiochemistry Unit will remain in a state of preparedness, for both emergency and routine surveillance samples, by keeping a sufficient stock of supplies, by periodic preventative maintenance of instrumentation, and by keeping an inventory of spare parts for the instrumentation. It is proposed that three computer programs be developed. One program already performs several tasks, one is partially developed, and one has not yet been started. The first program has been developed to calculate a sample's gross alpha activity from its known alpha emitters. The calculated gross alpha activity can be compared to the experimental gross alpha activity to determine whether all of a sample's alpha activity has been accounted for. The program can also be used interactively to perform activity calculations and to help identify unknown radionuclides. One objective is to further develop this program to calculate a sample's gross beta activity from its known beta emitters. The second program has been partially developed to fit the peaks of alpha spectra in cases where there is considerable peak overlap. In some cases, peak overlap in spectra cannot be avoided; in other cases, peak overlap is the result of contamination or excessive broadening of the peaks, due to a high precipitate mass. In such cases, the peak fit program can be used to obtain more accurate information than could be obtained using a region of interest approach. It is proposed that this program be completed. It is proposed that a third program be written to optimize the use of labor and resources during and emergency situation. Any or these programs will be available to other FERN laboratories.

项目概要/摘要 威斯康星州立卫生实验室放射化学单位 计划与 FDA 和其他 FERN 实验室合作，以扩展当前的 快速筛选更多食品基质的方法，开发新的快速筛选方法 方法，并扩展和开发识别特定放射性核素的方法。 一些工作密集型步骤（例如湿灰化和色谱法）需要 受到分析师的高度关注。建议将这些步骤 自动化以提高样品制备速率并允许分析人员 花更多的时间在其他任务上。放射化学单位将保持在 为紧急和例行监测样本做好准备，方法是保存 通过定期预防性维护，储备充足的物资 仪器仪表，并保留备件库存 仪器仪表。 建议开发三个计算机程序。一个程序 已经执行多项任务，其中一项已部分开发，一项尚未完成 已开始。第一个程序已开发用于计算样本的 来自其已知阿尔法发射体的总阿尔法活动。计算出的总 alpha 活性可以与实验总α活性进行比较以确定 是否已考虑样本的所有 alpha 活动。该程序可以 也可交互地用于执行活动计算并帮助识别 未知的放射性核素。目标之一是进一步开发该计划 根据已知的 β 发射体计算样品的总 β 活性。第二个 程序已部分开发以适应某些情况下的 α 光谱峰值 其中存在相当大的峰值重叠。在某些情况下，峰值重叠 光谱无法避免；在其他情况下，峰值重叠是由于 由于大量沉淀而导致污染或峰过度变宽 大量的。在这种情况下，可以使用峰值拟合程序来获得更准确的结果。 使用感兴趣区域方法可以获得的信息。这是 建议完成该计划。建议第三个方案是 为在紧急情况下优化劳动力和资源的使用而编写 情况。任何或这些程序都将可供其他 FERN 实验室使用。