Research Training in Allergy and Clinical Immunology

过敏和临床免疫学研究培训

• 批准号: 10686797
• 负责人: David B. Peden
• 金额: $ 44.39万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-19 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686797
• 关键词: Clinical Immunology; Hypersensitivity; Research Training

Abstract The goal of this project is to develop innovative physicians and PhD scientists trained in the latest methods of laboratory, translational and clinical research and fully prepared to pursue independent research careers investigating critical issues in Allergy and Immunology (A/I). For over 40 years this program has produced leaders in the field of A/I. This application maintains the training collaboration established between the complementary A/I training programs at Duke University and The University of North Carolina Chapel Hill (UNC). The combined strength of their A/I programs and their respective Universities create an ideal venue for training the next generation of A/I investigators. This proposal continues a highly innovative program for both physicians and PhD trained scientists in translational research in immune- based diseases. These goals will be accomplished through 1) formal courses in clinical research design, 2) rigorous training in basic immunology and 3) a structured mentorship program. Our research emphasis areas are designed to address these future needs in the field: 1) Human Immune Response to Pathogens, 2) Immunobiology of Food Allergy and 3) Pathobiology of Asthma, Respiratory and Allergic Disease. Mentors were selected from highly integrated and focused programs currently in place at Duke and UNC who demonstrated research productivity. Additionally, in this cycle we will bring an increased focus to Diversity, Equity and Inclusion as well as the mentor development of junior faculty who will become future established mentors. This application requests support for five trainees each year. Fulfillment of the program's objective would directly or indirectly serve to meet two urgent medical needs: 1) the need for more full-time researchers and teachers of allergy and clinical immunology in medical schools throughout the country and 2) the need for more physicians trained in the specific care of patients with allergic and immunologic disorders.

抽象的 该项目的目的是开发以最新方法的培训的创新医生和博士学位科学家 实验室，翻译和临床研究，并准备从事独立研究职业 调查过敏和免疫学（A/I）中的关键问题。 40多年来，该计划培养了领导者 在A/I领域。该应用程序维护互补之间建立的培训合作 杜克大学和北卡罗来纳大学教堂山（UNC）的A/I培训计划。这 他们的A/I课程及其各自的大学的结合力量创造了理想的培训场所 下一代A/I调查人员。该提案继续为这两个提案提供了一个高度创新的计划 医师和博士学位培训了免疫疾病转化研究的科学家。这些目标 将通过1）临床研究设计的正式课程完成，2）基本的严格培训 免疫学和3）结构化指导计划。我们的研究强调领域旨在 解决该领域的这些未来需求：1）人类对病原体的免疫反应，2）免疫生物学 食物过敏和3）哮喘，呼吸和过敏性疾病的病理生物学。从中选择了导师 目前在Duke和UNC的高度集成和集中的计划，他们展示了研究 生产率。此外，在这个周期中，我们还将增加对多样性，公平和包容性的重点 作为初级教师的导师发展，他们将成为未来的成熟导师。此应用程序 每年要求五名学员的要求。实现该计划的目标将直接或间接地实现 满足两个紧急医疗需求：1）需要更多的全职研究人员和过敏和老师 全国医学院的临床免疫学和2）需要更多接受培训的医生 在患有过敏和免疫疾病的患者的特定护理中。

项目成果

Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization.

• DOI: 10.1016/j.jaci.2010.12.1083
• 发表时间: 2011-03
• 期刊: The Journal of allergy and clinical immunology
• 作者: Kim EH;Bird JA;Kulis M;Laubach S;Pons L;Shreffler W;Steele P;Kamilaris J;Vickery B;Burks AW
• 通讯作者: Burks AW

The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.

上皮细胞来源的特应性皮炎细胞因子 TSLP 激活神经元以诱发瘙痒。

• DOI: 10.1016/j.cell.2013.08.057
• 发表时间: 2013-10-10
• 期刊: Cell
• 影响因子: 64.5
• 作者: Wilson SR;Thé L;Batia LM;Beattie K;Katibah GE;McClain SP;Pellegrino M;Estandian DM;Bautista DM
• 通讯作者: Bautista DM

What Is the Cause of the Chronic Erythematous Scaling Plaques on This 22-Month-Old Girl and Her Family?

这位 22 个月大的女孩及其家人出现慢性红斑鳞屑的原因是什么？

• DOI: 10.1177/0009922817738347
• 发表时间: 2018
• 期刊: Clinical pediatrics
• 影响因子: 1.6
• 作者: Ro,Teresa;Sood,Amika;Kelly,KevinJ;Morrell,DeanS
• 通讯作者: Morrell,DeanS

Pathogenesis of food allergy in the pediatric patient.

• DOI: 10.1007/s11882-012-0296-x
• 发表时间: 2012-12
• 期刊: CURRENT ALLERGY AND ASTHMA REPORTS
• 影响因子: 5.5
• 作者: Chin, Stacy;Vickery, Brian P.
• 通讯作者: Vickery, Brian P.

Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.

• DOI: 10.4049/jimmunol.1402195
• 发表时间: 2015-04-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Nakano H;Moran TP;Nakano K;Gerrish KE;Bortner CD;Cook DN
• 通讯作者: Cook DN