Interest, Preference, and Uptake of Long Acting ART among PLWH in Florida

佛罗里达州 PLWH 中的长效 ART 的兴趣、偏好和采用情况

• 批准号: 10685278
• 负责人: Rebecca J Fisk
• 金额: $ 4.19万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-16 至 2024-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10685278
• 关键词: Adherence; Administrator; Adult; Affect; Alcohol consumption; Alcohols; Attitude; Caring; Characteristics; Cohort Studies; Collaborations; Data; Data Analyses; Data Collection; Decision Making; Development; Enrollment; Epidemic; Failure; Florida; Formulation; Funding; Goals; Grant; HIV; HIV disparities; Health; Health behavior; Healthcare Systems; Incidence; Individual; Injectable; Interview; Learning Skill; Measures; Modeling; Modernization; Outcome; Patients; Perception; Persons; Pharmaceutical Preparations; Policies; Population; Population Heterogeneity; Provider; Public Health; Recommendation; Regimen; Research; Risk Reduction; Stigmatization; Substance Use Disorder; Translations; United States; United States National Institutes of Health; Viral; Viral Load result; Visit; alcohol abuse therapy; alcohol availability; alcohol research; antiretroviral therapy; care providers; career; career development; contextual factors; design; drinking; experience; experimental study; forgetting; health care cost/financing; high risk drinking; improved; insight; interest; novel; optimism; pill; preference; programs; responsible research conduct; side effect; skills; social; social stigma; structural determinants; substance use; substance use treatment; success; system-level barriers; therapy adherence; tool; transmission process; uptake

Project Summary A newly approved long-acting injectable (LAI) form of antiretroviral therapy (ART) is now available, and several other long-acting formulations are in development. These provide new tools to achieve the ambitious goals described in the initiative to End the HIV Epidemic in the United States by helping more people living with HIV (PLWH) achieve durable viral suppression. Because alcohol use is associated with decreased adherence, these treatments may be especially helpful among PLWH who drink. The impact of these exciting new treatments will be proportional to their uptake, which will be affected by both individual preferences and systemic factors. Previous studies have shown high levels of interest in LAI-ART but have not generally accounted for systemic factors that may hinder LAI-ART uptake. The long-term goal of the proposed research is to inform programs to improve ART adherence for PLWH. To help achieve this goal, the aims of this F31 grant are to: 1) determine which individual- and interpersonal-level factors are associated with preferences for a quarterly LAI-ART over taking daily pills in PLWH, focusing on populations with lower ART adherence and at- risk drinking, using existing data from the Florida Cohort study; 2) describe PLWH’s preferences for long-acting ART (LA-ART) formulations and determine which treatment attributes drive these preferences by implementing a best-best discrete choice experiment and explore whether preferences vary by drinking status and viral suppression; and 3) to conduct in-depth qualitative interviews with 20 stakeholders involved in HIV medication procurement and prescribing (e.g., HIV-care providers and clinician administrators) to gain insight into their attitudes towards and prescribing preferences of different LA-ART formulations, how these are impacted by patients’ alcohol use, systems-level barriers and facilitators of prescribing LA-ART, and how these visits can be used to increase the accessibility of alcohol-related care. Conducting this study will help me develop cross- cutting skills to achieve my long-term career goals of designing programs to improve health outcomes for PLWH, especially those who drink by focusing on: 1) measuring of individual preferences and decision-making related to health, 2) obtaining expertise in qualitative data collection and analysis, 3) gaining a better understanding of public healthcare financing related to HIV treatment and substance use, 4) learning skills related to professional and career development, and 5) responsible conduct of research. This study will leverage the ongoing Florida Cohort study, which is enrolling a diverse population of adult PLWH, and collaborations between Southern HIV and Alcohol Research Consortium and the Florida Department of Health and HIV care providers. These data can inform funding allocation and policy changes to support these ART preferences and can be extrapolated to treatments for alcohol and other substance use disorders to help focus development of novel medications or develop programs to help better integrate HIV care and alcohol-related treatment.

项目摘要 现已获得一种新批准的抗逆转录病治疗（ART）的长期批准的（LAI）形式，有几个 其他长效表述正在开发中。 通过帮助越来越多的艾滋病毒患者来终止美国HIB流行的倡议 （PLWH）实现耐用的病毒式增长。 这些治疗可能在这些令人兴奋的新型的PLWH中特别有用。 治疗将与他们的摄取成正比，这将受到个人偏好和 系统性因素。 考虑了可能阻碍LAI-ART吸收的系统因素。 是为了提高程序的依从性，以帮助实现这一目标 授予是：1）确定哪些个人和人际级别因素与偏好有关 每天在PLWH服用每日药的季度LAI部分，重点是具有领导人和AT-的人群 使用佛罗里达队列研究的现有数据风险饮用； 2） 艺术（LA-ART）配方，并确定哪种治疗属性通过掩盖来推动这些偏好 最好的最佳离散选择实验，并探索偏好是否因饮酒状态和病毒而变化 Suppness; 3）与参与HIV药物的20个利益相关者联系 采购和处方（例如，艾滋病毒护理提供者和临床医生的管理员）洞悉其 对不同LA-ART形成的侵蚀的态度，并受到这些形式的影响 患者的饮酒，系统级障碍和处方药处方的促进者 用于增加与酒精相关的护理的可及性。 削减技能以实现我设计计划的长期职业目标，以改善健康成果 PLWH，尤其是通过关注：1）测量个人偏好和决策的饮料 与健康有关，2）获得定性数据收集和分析方面的专家，3）获得更好的 了解与艾滋病毒治疗和药物使用有关的公共医疗融资，4）学习技能 与专业和职业发展有关 利用Ongolida队列研究，该研究正在招募各种各样的成人PLWH和 南部艾滋病毒和酒精研究联盟和佛罗里达卫生部的合作 和Hib护理提供商。 偏好，可以推断为酒精Ander药物使用障碍的治疗方法，以帮助聚焦 开发新型药物或开发计划以更好地整合Hib护理和与酒精有关 治疗。

项目成果

Assessing HIV-related stigma in the clinical setting: are providers in Florida interested?

评估临床环境中与艾滋病毒相关的耻辱：佛罗里达州的提供者感兴趣吗？

• DOI: 10.1080/09540121.2023.2279981
• 发表时间: 2024
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Fisk-Hoffman,RebeccaJ;Woody,Aislinn;Prosperi,Mattia;Cook,RobertL;Cook,Christa;Vaddiparti,Krishna
• 通讯作者: Vaddiparti,Krishna