Biospecimen Core

生物样本核心

• 批准号: 10683320
• 负责人: DAVID M OWENS
• 金额: $ 45.08万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683320
• 关键词: Age; Aging; Atlases; Autopsy; Biological; Blood; Blood Vessels; Brain; Central Nervous System; Cerebrospinal Fluid; Clinical; Cognitive; Collaborations; Collection; Complex; Consent; Data; Data Linkages; Dermatopathology; Disease; Ear; Environmental Exposure; Ethnic Origin; Evaluation; Foundations; Freezing; Gene Expression Profile; Genetic; Goals; Histopathology; Human; Individual; International; Leadership; Link; Longevity; Medical center; Methodology; Methods; Microscopic; Molecular; Molecular Profiling; New York; Operative Surgical Procedures; Organ; Outcome; Paraffin; Pathologic; Pathology; Phenotype; Positioning Attribute; Predisposition; Prefrontal Cortex; Process; Proteins; Research; Resources; Sampling; Site; Skin; Spinal Cord; Stains; Standardization; Subjects Selections; Sun Exposure; System; Techniques; Time; Tissue Banks; Tissues; Universities; age effect; age related; aged; biobank; body system; cell injury; cell type; clinical phenotype; cohort; data sharing; human tissue; innovation; multi-scale atlas; neuropathology; normal aging; prospective; regenerative; senescence; synergism; tissue mapping

BIOSPECIMEN CORE (BIO): PROJECT SUMMARY Aging is characterized by the accumulation of molecular and cellular damage resulting in decreasing cellular functionality. The extent and temporal progression of this damage is a heterogeneous process due to the complex interactions of environmental and genetic factors that can ameliorate and/or exacerbate normal aging. The overarching goal of the Columbia University Senescence Tissue Mapping (CUSTMAP) Center is to focus on key organ systems with vulnerability to age-related degenerative processes; the central nervous system and skin. These systems were selected as they represent organs with prominent adaptive/regenerative ability and heterogeneous cell types that will allow us to investigate the local effects of aging on gene expression signatures and how this impacts upon cellular composition and increase susceptibility to age-related damage and diseases. At the core of the CUSTMAP Center is consistent accessibility to well-phenotyped, high-quality, non-diseased human tissue that has been consented for broad data sharing. We are ideally positioned for this effort through our premier clinical phenotyping and biobanking resources. Through our Biospecimen Core (BIO), we will compile one of the largest multinational cohorts with tissues spanning the lifespan, with comparable and quantifiable clinical correlates, by continuing our prospective collection of comparably phenotyped high quality cases at both the University of Edinburgh and Columbia University Irving Medical Center. Our BIO will bring together a leadership team from diverse clinical and research backgrounds with complementary established expertise in clinical phenotyping and tissue biobanking. The aim of this core is not only to synergize with our Biological Analysis Core to deliver the outcomes of the proposed aims, but also to establish an international framework for a standardized approach to phenotypic tissue banking. Our hope is that by establishing this framework it will enable a higher quality of ante- and post-mortem, human-relevant research to be carried out in this field.

生物样本核心 (BIO)：项目摘要 衰老的特点是分子和细胞损伤的积累，导致细胞活力下降 功能。这种损害的程度和时间进展是一个异质过程，因为 环境和遗传因素之间复杂的相互作用，可以改善和/或加剧正常的 老化。哥伦比亚大学衰老组织图谱 (CUSTMAP) 的总体目标 中心重点关注易受年龄相关退化过程影响的关键器官系统；中央 神经系统和皮肤。选择这些系统是因为它们代表具有突出特征的器官 适应/再生能力和异质细胞类型将使我们能够研究局部效应 衰老对基因表达特征的影响以及这如何影响细胞组成并增加 易受与年龄相关的损害和疾病的影响。 CUSTMAP 中心的核心是一致的 获得已同意的表型良好、高质量、无病的人体组织 广泛的数据共享。通过我们一流的临床表型分析和 生物样本库资源。通过我们的生物样本核心 (BIO)，我们将编制最大的生物样本之一 具有跨越生命周期的组织的跨国队列，具有可比较和可量化的临床 相关性，通过继续我们在两个地方收集具有可比表型的高质量病例 爱丁堡大学和哥伦比亚大学欧文医学中心。我们的 BIO 将汇集 领导团队来自不同的临床和研究背景，具有互补的现有专业知识 临床表型分析和组织生物库。该核心的目的不仅是与我们的生物协同作用 分析核心以实现拟议目标的成果，同时建立一个国际框架 表型组织库的标准化方法。我们希望通过建立这个框架 将使该领域能够进行更高质量的事前和事后、与人类相关的研究。