Genomics for Social Scientists: 2022-2027

社会科学家基因组学：2022-2027

• 批准号: 10681465
• 负责人: Jessica Faul
• 金额: $ 15.01万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681465
• 关键词: Address; Adolescent; Adult; Aging; Area; Behavioral; Biological; Biological Assay; Biological Sciences; Biology; Biosocial; Code; Collaborations; Collection; Communities; Complement; Complex; Custom; DNA; DNA Methylation; Data; Data Files; Databases; Discipline; Education; Educational process of instructing; Educational workshop; Electronic Mail; Epigenetic Process; Evaluation; Exercise; Funding; Generations; Genes; Genetic; Genetic Research; Genetic study; Genomics; Gerontology; Goals; Health; Health Sciences; Health and Retirement Study; Human; Infrastructure; Instruction; Internet; Investments; Knowledge; Language Development; Length; Link; Longitudinal Studies; Longitudinal cohort study; Measures; Mentors; Methodology; Methods; Modeling; Molecular; National Longitudinal Survey of Adolescent to Adult Health; Northern Ireland; Outcome; Participant; Persons; Phenotype; Population; Population Study; Protocols documentation; Publications; Publishing; Quality Control; Race; Reporting; Research; Research Methodology; Research Personnel; Resources; Sampling; Scientist; Secure; Series; Social Sciences; Societies; Statistical Methods; Students; Surveys; Training; Translating; United States National Institutes of Health; behavioral and social science; cost; diversity and inclusion; education research; experience; genome resource; genome sciences; genomic data; genomic predictors; health disparity; improved; interest; learning materials; meetings; online resource; online tutorial; phenotypic data; population based; portability; prediction algorithm; programs; sample collection; skills; social; social factors; social genomics; social science research; symposium; telomere; theories; tool; trait; virtual; web site

Project Summary In this application, we propose to continue the aims of R25 AG053227 Genomics for Social Scientists by offering two annual summer workshops, one a week-long introduction to genomics and another 4-day workshop focused on epigenetics. This doubles the number of courses offered by including the epigenetics course that was created with a recent supplement. In addition to an expanded series of online modules based on aspects of the course we have found particularly well-suited to online instruction, these courses will build the capacity of social and behavioral scientists to understand and conduct genomic (i.e. DNA, epigenetics, telomere length, etc.) research using NIA-funded resources, such as the Health and Retirement Study (HRS), The Irish Longitudinal Study on Ageing (TILDA), Northern Ireland Cohort for the Longitudinal study of Ageing (NICOLA), and The National Longitudinal Study of Adolescent to Adult Health (Add Health). Our proposed R25 Research Education Program will expand the opportunity for social science researchers using these data to integrate genomics into their research by 1) offering two annual in-person and virtual training workshops with a hands-on lab component, 2) creating a series of online tutorials that can augment the workshop or serve as stand-alone exercises, and 3) linking these custom tools with resources already available on the web (i.e. facilitating more efficient use of resources typically unknown to most social scientists). The courses and supporting material will focus on providing training for researchers working at the intersection of genomic and social science research, using HRS data as a model, but broadly applicable to any social science study with genomic data. We will cover a biological overview of genomics, collection of genomic material in population- based studies, as well as an introduction to current quality control metrics and statistical methods for studying human complex traits. Hands-on analysis is an integral part of each course and will utilize tutorial versions of the HRS core survey data and files similar to the HRS genetic and epigenetic data files accessed using a secure virtual desktop infrastructure (VDI). Our team consists of experts linking social science and genomic data in their own aging research, including collecting, assaying, and analyzing genomic samples and data. Moreover, this team has taught over 180 students in 7 different courses over the last 5 years. Evaluations of the course have been very positive and each year the course material has improved and been modified to better fit the needs of the students and stay up to date with developing methodologies. Students have demonstrated tremendous potential for impact on the field publishing nearly 400 articles using genomic data thus far. Ultimately our goal is that through discussion and by example we will focus on the unique aspects of analyzing genetic and epigenetic data in combination with social science data to facilitate collaboration across disciplines for the workshop attendees.

项目摘要 在此应用中，我们建议继续通过R25 AG053227基因组学为社会科学家的目标 提供两个年度夏季研讨会，为期一周的基因组学介绍和另外4天 专注于表观遗传学的研讨会。这使包括表观遗传学的课程数量增加了一倍 当然是通过最近的补充来创建的。除了扩展的基于在线模块的系列 在课程的各个方面，我们发现特别适合在线教学，这些课程将建立 社会和行为科学家了解和进行基因组的能力（即DNA，表观遗传学， 端粒长度等。）使用NIA资助的资源（例如健康与退休研究（HRS））的研究， 爱尔兰纵向衰老纵向研究（Tilda），北爱尔兰队列的衰老纵向研究 （尼古拉），以及针对成人健康青少年的国家纵向研究（ADD健康）。我们建议的R25 研究教育计划将扩大使用这些数据的社会科学研究人员的机会 通过1）将基因组学纳入其研究中 动手实验室组件，2）创建一系列可以增加研讨会或用作的在线教程 独立练习，以及3）将这些自定义工具与网络上已经可用的资源联系起来（即 促进大多数社会科学家通常不知道的更有效利用资源）。课程和 支持材料将着重于为在基因组和基因组交集的研究人员提供培训 社会科学研究，使用人力资源数据作为模型，但广泛适用于任何社会科学研究 基因组数据。我们将涵盖基因组学的生物学概述，人群中基因组材料的收集 - 基于研究的研究以及当前质量控制指标和研究的统计方法 人类复杂的特征。动手分析是每个课程不可或缺的一部分，将使用教程版本 HRS核心调查数据和文件类似于使用A访问的HRS遗传和表观遗传数据文件 保护虚拟桌面基础架构（VDI）。我们的团队由联系社会科学和基因组联系的专家组成 他们自己的老化研究中的数据，包括收集，分析和分析基因组样本和数据。 此外，在过去的5年中，该团队在7个不同的课程中教授了180多名学生。评估 该课程非常积极，每年课程材料都得到改善，并经过修改为 更好地满足学生的需求，并了解开发方法。学生有 使用基因组数据证明了对现场发表近400篇文章的影响的巨大潜力 到目前为止。最终，我们的目标是通过讨论，以身作则，我们将专注于 分析遗传和表观遗传数据与社会科学数据结合，以促进跨越 研讨会与会者的学科。