Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

将中风后处理速度的提高转移到日常认知任务中

• 批准号: 10682264
• 负责人: Edward Taub
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682264
• 关键词: Address; Adult; Aftercare; Applications Grants; Basic Science; Behavioral; Clinical Research; Cognitive; Cognitive Therapy; Combined Modality Therapy; Data; Data Analyses; Development; Fostering; Funding; Grant; Impaired cognition; Impairment; Intervention; Life; Manuscripts; Measures; Methods; Participant; Patients; Performance; Process; Randomized, Controlled Trials; Rehabilitation therapy; Request for Applications; Research; Research Activity; Research Personnel; Scientist; Single-Blind Study; Site; Speed; Stroke; Structure; Techniques; Training; Writing; arm; career; chronic stroke; cognitive task; constraint induced movement therapy; constraint induced therapy; design; efficacy evaluation; improved; information processing; instrumental activity of daily living; neurological rehabilitation; new combination therapies; parent grant; post stroke; processing speed; programs; skills; symposium; treatment effect

ABSTRACT This Diversity Supplement application is connected to funded grant R01 AG070049 (Title: Transferring Speed of Processing Gains to Everyday Life; PI: E. Taub; Project Period: 9/5/2021- 8/31/2022). This application requests funds to provide training in neurorehabilitation research to the proposed Diversity Supplement candidate in association with the clinical study supported by the parent grant. The purpose of the parent grant is to conduct a randomized controlled trial (RCT) to evaluate the efficacy of a new treatment, Constraint-Induced (CI) Cognitive Therapy, for improving cognitive impairment in patients with chronic stroke. CI Cognitive Therapy combines two repeatedly validated rehabilitation methods: the Transfer Package of CI Movement Therapy and Speed of Cognitive Processing Training. The purpose of doing so is to produce a marked enhancement in the transfer of cognitive improvement from the training setting to instrumental activities of daily living (IADL) in everyday situations. Both halves of the new combination therapy are founded on the investigators’ own basic research. In both cases, efficacy is supported by positive results from multiple single-site RCTs and a large multisite RCT. However, the effect of Speed of Processing Training (SOPT) has been found to have limited generalization to cognitive-based IADL in everyday situations. In contrast, one of the main strengths of CI Therapy is that it produces a robust and extensive transfer of treatment effect to everyday life situations by means, in part, of its Transfer Package (TP). The parent grant involves a single-blind RCT with two arms: SOPT with the TP vs. SOPT without the TP. Participants will be 120 adults more than 1-year post-stroke with mild to moderate cognitive impairment. Performance on cognitive tasks will be measured in daily life and in the lab before and after baseline, after treatment, and 6- and 12-months afterwards. To expand the research skills of the Diversity Supplement candidate and foster her development as a career as an independent scientist, this application proposes a two-year, structured program of didactic training in grant writing and data analysis, hands-on training in the design and conduct of neuro-rehabilitation research, independent research activity, manuscript and grant application development, and presentation of data at scientific conferences.

抽象的 此多样性补充申请与资助的资助R01 AG070049连接（标题：转让 加工速度到日常生活； pi：E。Taub;项目期间：9/5/2021- 8/31/2022）。这 申请要求资金为拟议多样性提供神经居住研究的培训 与父母赠款支持的临床研究相关的补充候选人。 父母赠款的目的是进行随机对照试验（RCT）来评估 新疗法的功效，约束诱导的（CI）认知疗法，以改善认知障碍 慢性中风的患者。 CI认知疗法结合了两种反复验证的康复方法： CI运动疗法的转移套餐和认知处理训练的速度。目的 这样做是从训练环境中产生明显的认知改善转移的增强 在每天的情况下进行日常生活的乐器活动（IADL）。新组合的两半 治疗是基于研究人员自己的基础研究。在这两种情况下，有效都得到积极的支持 来自多个单位RCT和大型多站点RCT的结果。但是，处理速度的影响 在每天的情况下，培训（SOPT）对基于认知的IADL的概括有限。 相比之下，CI疗法的主要优势之一是它产生了强大而广泛的转移 每天通过其转移套餐（TP）对生命情况的治疗效果。 父母赠款涉及一个带有两个臂的单盲RCT：带有TP与SOPT的SOPT TP。参与者将是120名成年人，超过1年，并具有轻度至中度的认知障碍。 认知任务的表现将在日常生活中和基准前后的实验室中测量 治疗以及6个月和12个月。 扩大多样性补充候选人的研究技能，并促进她的发展 作为独立科学家的职业，该申请提出了一项为期两年的教学培训的结构化计划 在赠款写作和数据分析中，神经护理研究的设计和行为的动手培训， 独立的研究活动，手稿和授予应用程序的开发以及数据的呈现 科学会议。