Scaffolding of brain operations: the role of beta oscillations in forming flexible neural ensembles

大脑运作的脚手架：β振荡在形成灵活的神经系统中的作用

• 批准号: 10680378
• 负责人: Saskia Haegens
• 金额: $ 45.66万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680378
• 关键词: Animals; Apical; Architecture; Area; Auditory; Behavior; Behavioral; Beta Rhythm; Biological Markers; Brain; Cells; Cognition; Cognitive deficits; Communication; Decision Making; Dendrites; Destinations; Distal; Electroencephalography; Electrophysiology (science); Environment; Event; Feedback; Frequencies; Future; Generations; Goals; Impaired cognition; Impairment; Investigation; Link; Location; Maintenance; Mediating; Methods; Microscopic; Modality; Modeling; Mus; Opsin; Outcome; Paper; Parietal; Parkinson Disease; Patients; Pattern; Perception; Performance; Physiology; Play; Population; Prefrontal Cortex; Process; Pyramidal Cells; Research; Research Project Grants; Rodent; Role; Route; Sampling; Schizophrenia; Sensory; Short-Term Memory; Signal Transduction; Site; Stimulus; Tactile; Task Performances; Techniques; Testing; Thalamic structure; Visual; Work; awake; biomarker identification; cell assembly; design; flexibility; human subject; information processing; insight; neural; neuronal circuitry; neuroregulation; novel; operation; optogenetics; programs; scaffold; source localization; transmission process

PROJECT SUMMARY The brain constantly makes decisions based on perceptual input as well as internal signals, quickly weighing and processing information, leading to goal-directed behavior. One key aspect crucial to all these processes is communication: the transfer of information from one brain network to the next. However, we are only beginning to understand how the brain accomplishes this. Here we propose to study exactly this question. The overarching goal of this project is to elucidate how the brain sets up the functional neural architecture involved in working memory and decision- making. We argue that brain oscillations in the beta frequency band (15–30 Hz) play a critical role in forming flexible neural ensembles. We propose a novel theoretical framework, delineating how the beta rhythm flexibly sets up transient networks, linking neuronal circuits that are relevant to current task demands, especially in terms of endogenous information processing (e.g., working memory, decision-making). In this view, beta provides the scaffolding for information transfer, routing information through the brain by temporarily connecting relevant nodes such that exchange of information can take place. We propose that the beta rhythm briefly activates a neural ensemble, allowing it to broadcast its message—encoded in (population) spike activity—such that it can be efficiently and effectively received. To test this framework, we here aim to: 1) examine the role of beta oscillations in dynamic neural ensemble formation and its relation to behavioral performance, 2) identify the underlying circuit-level physiology of beta-mediated ensemble formation, and 3) establish the generality of beta-mediated ensemble formation and identify non- invasive biomarkers. We will use a combination of EEG recordings in healthy human subjects, and intracranial electrophysiology and optogenetic neuromodulation in awake-behaving rodents. Both human subjects and animals will perform a spatial working-memory paradigm, critically allowing vertical integration across recording levels. Human subjects will additionally perform working-memory tasks in different sensory modalities and at higher levels of abstraction to guarantee generalizability of results, and to allow for identification of biomarkers to be used in future patient studies. This approach is designed to answer core mechanistic questions: how are local ensembles formed and how are these modulated? Critically, we will determine the effect of these mechanisms on behavior. The project will provide fundamental insights that will set the stage for further detailed investigations in healthy human subjects and patients with impaired beta functioning and cognitive impairment, such as in Parkinson’s disease and schizophrenia.

项目摘要 大脑不断根据感知输入和内部信号做出决定 快速加权和处理信息，导致目标指导的行为。一个关键方面 对所有这些过程至关重要的是通信：信息从一个大脑网络传输 到下一个。但是，我们才开始了解大脑如何实现这一目标。这里 我们建议准确研究这个问题。该项目的总体目标是阐明 大脑建立了与工作记忆和决策有关的功能性神经结构 - 制作。我们认为β频带（15–30 Hz）中的大脑振荡起着至关重要的作用 在形成灵活的神经合奏时。我们提出了一个新颖的理论框架，描述了如何 beta节奏灵活地建立了瞬态网络，链接了与 当前的任务需求，尤其是在内生信息处理方面（例如，工作 记忆，决策）。在此观点中，Beta提供了信息传输的脚手架， 通过临时连接相关节点，通过大脑路由信息 信息交换可以进行。我们建议β节奏短暂激活中性 合奏，允许其广播其信息 - 编码（人口）尖峰活动 - 它可以有效地有效地接收。要测试此框架，我们在这里的目的是：1）检查 β振荡在动态神经合奏形成中的作用及其与行为的关系 性能，2）确定β介导的集合的基础电路级生理 形式和3）建立β介导的合奏形成的一般性，并确定非 - 侵入性生物标志物。我们将在健康的人类受试者中使用脑电图记录的组合， 在清醒啮齿动物中，颅内电生理学和光遗传学神经调节。 人类受试者和动物都会执行空间工作记忆范式，批判性地 允许在记录级别上进行垂直集成。人类受试者还将执行 以不同的感觉方式和更高水平的抽象级别的工作记忆任务 确保结果的普遍性，并允许使用生物标志物 未来的患者研究。这种方法旨在回答核心机理问题：如何 形成了本地合奏，这些如何调制？至关重要的是，我们将确定 这些关于行为的机制。该项目将提供基本见解，以设定 在健康的人类受试者和Beta受损患者中进行进一步详细研究的阶段 功能和认知障碍，例如帕金森氏病和精神分裂症。

项目成果

β Band Rhythms Influence Reaction Times.

β 带节律影响反应时间。

• DOI: 10.1523/eneuro.0473-22.2023
• 发表时间: 2023
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Rassi,Elie;Lin,WyMing;Zhang,Yi;Emmerzaal,Jill;Haegens,Saskia
• 通讯作者: Haegens,Saskia

Distinct beta frequencies reflect categorical decisions.

• DOI: 10.1038/s41467-023-38675-3
• 发表时间: 2023-05-22
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Rassi, Elie;Zhang, Yi;Mendoza, German;Mendez, Juan Carlos;Merchant, Hugo;Haegens, Saskia
• 通讯作者: Haegens, Saskia

Visual working memory recruits two functionally distinct alpha rhythms in posterior cortex.

视觉工作记忆在后皮质中招募两种功能不同的阿尔法节律。

• DOI: 10.1523/eneuro.0159-22.2022
• 发表时间: 2022
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Rodriguez-Larios,Julio;ElShafei,Alma;Wiehe,Melanie;Haegens,Saskia
• 通讯作者: Haegens,Saskia