Emotion regulation, ART adherence, and virologic status among adolescents and young adults living with HIV in Zambia

赞比亚青少年和年轻人艾滋病毒感染者的情绪调节、抗逆转录病毒治疗依从性和病毒学状况

• 批准号: 10679041
• 负责人: Kathleen Marie Ridgeway
• 金额: $ 4.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10679041
• 关键词: AIDS prevention; Accounting; Address; Adherence; Adolescence; Adolescent; Adolescent Development; Adolescent and Young Adult; Adult; Africa South of the Sahara; Behavior; Biological; Blood; Caregivers; Caring; Complex; Data; Data Collection; Development; Ensure; Epidemic; Equation; Evidence based intervention; Face; Factor Analysis; Failure; Family; Family Caregiver; Family Relationship; Fellowship; Goals; HIV; HIV Seropositivity; HIV-infected adolescents; Health; Home; Intervention; Intervention Studies; Interview; Knowledge; Measures; Mediating; Mediation; Mental Depression; Mentorship; Methods; Modeling; Modification; NIH Program Announcements; National Research Service Awards; Outcome; Parents; Physiological; Play; Population; Process; Public Health Schools; Qualitative Methods; Questionnaires; Randomized; Regimen; Research; Research Methodology; Research Personnel; Risk; Role; Sampling; Self Management; Social Change; Statistical Data Interpretation; Structure; Tenofovir; Testing; Training; Translating; Trauma; Treatment outcome; Urine; Violence; Viral; Weight; Youth; Zambia; adolescent health; adolescent health outcomes; aged; behavioral response; career; caregiver interventions; cognitive development; cognitive interview; doctoral student; emotion dysregulation; emotion regulation; evidence base; experience; high risk sexual behavior; improved; informant; innovation; interest; peer; point of care; point of care testing; psychologic; skills; social factors; social stigma; transmission process

PROJECT SUMMARY/ABSTRACT Background: Nearly two-thirds of adolescents and young adults living with HIV (AYALHIV) in Zambia have virologic failure. To date, limited research has assessed the role of developmental factors in achieving positive HIV self-management behaviors and favorable health outcomes among AYALHIV. A comprehensive understanding of these factors is essential to respond to the HIV epidemic among this high-priority population. Study Goal and Aims: Leveraging a parent study that tests the AYALHIV-caregiver Family Connections intervention in Zambia, the proposed research will validate and assess a measure of adolescent development – emotion regulation – in relation to virologic failure, ART adherence, and family and social factors. Specific aims are: 1) Validate the Difficulties in Emotion Regulation Scale (DERS-SF) among AYALHIV in Zambia; 2) Examine associations between emotion dysregulation and a) virologic failure and b) incomplete ART adherence, assessing moderation and mediation by family and social factors; and 3) Use dyadic in-depth interviews with AYALHIV and caregivers to explore relationships identified in Aim 2 between emotion regulation and HIV self-management, and experiences with the Family Connections intervention, comparing AYALHIV with and without emotion regulation difficulties. Approach: Aims 1 and 2 of the proposed research will use secondary questionnaire data collected at baseline by the parent study; Aim 2 also uses measures of virologic status (blood draw) and ART adherence (urine point of care test). In Aim 1, a hierarchical confirmatory factor analysis will be used to validate the DERS-SF. Aim 2 will use structural equation modeling (SEM) to assess relationships between the DERS-SF, virologic status, and moderation and mediation by family and social factors; secondarily, a similar SEM be used to assess relationships with ART adherence. Aim 3 involves primary qualitative data collection with AYALHIV/ caregiver dyads, and will use an inductive approach to gain a nuanced understanding of Aim 2 relationships and AYALHIV's intervention experiences, comparing youth with and without emotion regulation difficulties. Fellowship Information: The proposed research is the doctoral dissertation of Ms. Kathleen Ridgeway, a PhD student at the Johns Hopkins Bloomberg School of Public Health. Ms. Ridgeway's research and training will be supported by experts in adolescent HIV research, qualitative methods, and advanced statistical analysis and includes one Sponsor, two co-Sponsors, and two Scientific Advisors. A combination of didactic coursework, mentorship, independent study, and practical experience will further Ms. Ridgeway's career goal to become a leading independent researcher in adolescent health and HIV. This proposal directly responds to the NIH Program Announcement (PA-18-651) and Notice of Special Interest (NOT-MH-20-035) for developmentally tailored HIV prevention and care research for adolescents and young adults.

项目摘要/摘要 背景：近三分之二的青少年和艾滋病毒（Ayalhiv）的年轻人有赞比亚 病毒学衰竭。迄今为止，有限的研究已经评估了发展因素在实现积极方面的作用 艾滋病毒的自我管理行为和良好的健康状况。全面 对这些因素的理解对于对这种高优先级人群中的艾滋病毒流行反应至关重要。 研究目标和目的：利用父母研究测试Ayalhiv-Careger family Connections 拟议的研究将在赞比亚进行干预，将验证和评估青少年发展的度量 - 情绪调节 - 与病毒学失败，艺术依从性以及家庭和社会因素有关。具体的 目的是：1）在赞比亚的Ayalhiv中验证情绪调节量表（DERS-SF）的困难； 2） 检查情绪失调与a）病毒衰竭和b）不完整的艺术 遵守，评估家庭和社会因素的节制和调解； 3）深入使用二元 与Ayalhiv和护理人员的访谈，以探索情感之间AIM 2中确定的关系 监管和艾滋病毒的自我管理，以及家庭联系干预的经验，比较 有和没有情绪调节困难的Ayalhiv。 方法：拟议的研究的目标1和2将使用基线收集的二级问卷数据 由父母研究； AIM 2还采用病毒学状态（抽血）和艺术依从性的度量（尿液 护理点测试）。在AIM 1中，将使用分层确认因子分析来验证DERS-SF。 AIM 2将使用结构方程建模（SEM）来评估DERS-SF，病毒学的关系 身份，家庭和社会因素的适度和调解；次级，类似的SEM被用作 评估艺术依从性的关系。 AIM 3涉及与Ayalhiv/的主要定性数据收集/ 护理人员的二元组，并将采用归纳方法来获得对目标2关系的细微理解 以及阿亚尔希夫（Ayalhiv）的干预经历，比较有或没有情绪调节困难的青年。 奖学金信息：拟议的研究是凯瑟琳·里奇韦女士的博士学位论文，博士学位 约翰·霍普金斯彭博公共卫生学院的学生。里奇韦女士的研究和培训将是 由青少年艾滋病毒研究，定性方法和高级统计分析的专家支持 包括一个赞助商，两个共同发起人和两名科学顾问。教学课程的结合， Menorship，独立研究和实践经验将进一步进一步成为Ridgeway女士的职业目标 青少年健康和艾滋病毒的领先独立研究员。该提案直接回应NIH 计划公告（PA-18-651）和特殊利益通知（NOT-MH-20-035） 针对青少年和年轻人的量身定制的HIV预防和护理研究。

项目成果

Reproductive empowerment and contraceptive self-care: a systematic review.

• DOI: 10.1080/26410397.2022.2090057
• 发表时间: 2021
• 期刊: SEXUAL AND REPRODUCTIVE HEALTH MATTERS
• 影响因子: 6
• 作者: Burke, Holly M.;Ridgeway, Kathleen;Murray, Kate;Mickler, Alexandria;Thomas, Reana;Williams, Katie
• 通讯作者: Williams, Katie