Vaping and Smoking Cessation in Intensive Longitudinal National Data

密集纵向全国数据中的电子烟和戒烟情况

• 批准号: 10679560
• 负责人: Junhan Cho
• 金额: $ 24.75万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679560
• 关键词: Abstinence; Address; Adult; Alcohols; Anxiety; Cannabis; Coronavirus; Costs and Benefits; Data; Data Sources; Development; Devices; Drug usage; Electronic cigarette; Equity; Face; Frequencies; Future; Goals; Health Benefit; Household; Illicit Drugs; Intake; Internet; Longitudinal Studies; Longitudinal cohort; Measures; Mediating; Mediation; Mediator; Mental Depression; Mental Health; Modeling; Moods; Motivation; Negative Reinforcements; Nicotine; Nicotine Dependence; Observational Study; Outcome; Paper; Pathway interactions; Persons; Policies; Population; Probability; Public Health; Regulation; Reporting; Research; Respondent; Sampling; Science; Selection Bias; Smoke; Smoker; Smoking; Surveys; Symptoms; Techniques; Testing; Time; anxiety reduction; anxiety symptoms; depressive symptoms; drinking; experience; follow-up; hazard; long term abstinence; multilevel analysis; nicotine inhalation; novel; pandemic impact; prospective; recruit; secondary analysis; smoking abstinence; smoking cessation; smoking relapse; sociodemographic factors; substance use; vaping; vaping nicotine

PROJECT SUMMARY The overall goal of this project is to determine whether vaping is associated with smoking cessation in US adults by conducting secondary analyses that leverage a novel “intensive” longitudinal national data source with bi-weekly survey waves. Current observational evidence of the association between vaping and smoking cessation using national longitudinal data sources (e.g., the PATH study) may provide insufficient temporal precision due to the long inter-survey intervals (e.g., 12-month). Long intervals are problematic because many smokers make multiple quit attempts within a year and vacillate between abstinence and smoking. In addition, given that smokers who try e-cigarettes are more likely to have nicotine dependence, have higher quit smoking motivation, and have sociodemographic factors that may impact cessation, selection biases are always a threat to observational studies examining vaping-assisted smoking cessation. Also, addressing mental health in studies examining the prospective association of vaping with smoking cessation is crucial because quit attempters may face anxiety, depression, and other symptoms that spike within the first several weeks of nicotine abstinence. To address this research gap, the proposed study will leverage the nationally representative longitudinal panel survey of the Understanding America Study, including 8,306 US adults with 26 bi-weekly survey waves (April 2020 - July 2021) and nine additional monthly follow-up surveys (October 2021 - June 2022) with past-week vaping and smoking frequency measures. Specifically, this study will use the subsample of baseline past-week smokers (n=1154, 16.6%) to assess bi-weekly associations of time-varying nicotine vaping with time-lagged smoking abstinences two weeks later across follow-ups extending up to 110 weeks after baseline, which will enable us to avoid insufficient temporal precision in previous national studies of vaping-assisted smoking cessation. In addition, intensive longitudinal multi-level modeling that partitions between- and within-subject variance to address between-person confounds will be used to test our hypothesized model of vaping-related smoking cessation, which will also mitigate selection bias. Specific research aims are to: (1) determine short-term (2 weeks) and long-term (up to 110 weeks) associations of daily or non-daily (vs. no) vaping with smoking cessation; (2) determine whether anxiety/depression symptoms are a mediator and consequence of vaping-related smoking cessation; (3) examine other substance use as a time- varying moderator of the association of vaping with smoking cessation and the anxiety/depression mediation pathway. The proposed study will address whether vaping encourages smokers to initiate and sustain smoking cessation in the real world, and if they experience cessation-related mental health benefits.

项目摘要 该项目的总体目标是确定烟是否与我们在美国的戒烟有关 成人通过进行二级分析来利用一种新颖的“密集”纵向国家数据来源 每两周进行调查浪。当前的观察证据表明烟与吸烟之间关联 使用国家纵向数据源（例如，路径研究）停止，可能会提供不足的临时性 由于长时间的间隔间隔（例如12个月），精度。长间隔是有问题的，因为很多 吸烟者在一年内进行多次戒烟，并在禁欲和吸烟之间度假。此外， 鉴于尝试电子烟的吸烟者更有可能具有尼古丁依赖性，因此戒烟较高 动机，并具有可能影响停止戒烟的社会人口统计学因素，选择偏见始终是 对观察性研究的威胁，以检查烟雾辅助戒烟。另外，解决心理健康 在研究烟与戒烟的前瞻性关联的研究中至关重要，因为退出 在此可能会面临动画，抑郁症和其他症状的症状 尼古丁禁欲。为了解决这一研究差距，拟议的研究将利用全国范围 代表美国理解研究的纵向小组调查，包括8,306名美国成年人 26个每两周一次的调查浪（2020年4月 - 2021年7月）和9次每月随访调查（10月 2021年至2022年6月），过去周的蒸气和吸烟频率测量。具体来说，这项研究将使用 基线上周吸烟者的子样本（n = 1154，16.6％），以评估每两周的时间变化关联 尼古丁在两周后随着时间停滞的戒烟而进行的尼古丁蒸发，随访延伸至110 基线后几周，这将使我们避免在先前的国家研究中暂时不足 烟雾辅助戒烟。此外，分区的密集纵向多层次建模 律师和主体内方差以解决人间混杂的问题将用于测试我们的 假设的与烟有关的戒烟模型，这也将减轻选择偏见。具体的 研究目的是：（1）确定每日的短期（2周）和长期（长达110周）的关联 或非每天（vs. no）戒烟； （2）确定焦虑/抑郁症状是否为 介体和烟有关的戒烟的后果； （3）将其他物质的使用作为时间 - 烟与戒烟和动画/抑郁调解的烟协会的不同主持人 路径。拟议的研究将解决Vaping是否鼓励吸烟者发起和维持吸烟 停止在现实世界中，如果他们遇到与戒烟有关的心理健康益处。