P30 - CENTER CORE GRANT FOR VISION RESEARCH

P30 - 愿景研究中心核心拨款

基本信息

批准号：
8689047
负责人：
LINDA M ZANGWILL
金额：
$ 74.29万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8689047
关键词：
Address Algorithms Anatomy Animal Model Animal Structures Animal Technicians Animals Applications Grants Appointment Area Basic Science Bioinformatics Biological Biological Markers Biology Biomedical Engineering Biometry Blood Vessels California Cancer Center Support Grant Cellular biology Center Core Grants Clinical Research Collaborations Communities Complex Computational Science Computer Analysis Computers Confocal Microscopy Cornea Data Data Set Descriptor Development Diabetic Retinopathy Educational process of instructing Electrophysiology (science)Engineering Ensure Environment Epidemiology Equipment Eye Eye diseases Faculty Family Practice Fostering Foundations Functional Imaging Funding Future Genetic Genomics Glaucoma Goals Health Sciences High Performance Computing Histology Housing Human Human Resources Image Image Analysis Immunohistochemistry Individual Information Technology Institutes Interdisciplinary Study Laboratories Laboratory Animals Letters Libraries Life Macular degeneration Mathematics Measurement Medical Medical Records Medicine Metadata Methodology Methods Microscope Molecular Biology Neurosciences Noise Online Systems Ophthalmology Pathology Pediatrics Pharmacologic Substance Prevention Preventive Medicine Process Productivity Psychology Radiology Specialty Reagent Recruitment Activity Research Research Infrastructure Research Personnel Resource Sharing Resources Retina Retinal Retinal Degeneration Science Scientist Secure Services Statistical Models Techniques Telecommunications Testing Time Tissues Training Travel United States National Institutes of Health Universities Vision Vision research Work animal care animal facility computer program computer science computing resources cost digital eye center fluorescence imaging health science research image processing imaging modality improved innovation insight instrument investigator training light microscopy meetings professor programs ranpirnase research study restoration square foot supercomputer tissue processing tool

项目摘要

DESCRIPTION (provided by applicant): This University of California, San Diego (UCSD) Vision Research Core grant proposal will provide critical resources in 4 distinct substantive areas to leverage the expertise of NEI funded UCSD investigators and to accelerate discoveries from their NIH funded studies. 15 investigators have a total of 18 NEI funded eligible R01 projects. These investigators from the UCSD Departments of Ophthalmology, Pathology, Pediatrics, Institute for Genomic Medicine, Radiology, and Psychology represent an impressive, productive, and a collegial group of vision researchers. UCSD vision researchers encompass all levels of faculty appointments and research accomplishments, from 9 full professors who are leaders in their respective fields to 6 recently recruited junior faculty (Drs. Annese, Balasubramanian, Bosworth, Huberman, Ju, Lin). Moreover, the substantial funding from other NIH institutes and foundations (Table 2) further highlights the strength of UCSD's vision research program. In particular, our portfolio is strong in human and animal imaging and functional assessment, image analysis, epidemiology/clinical research, genetics, glaucoma, AMD, retinal degeneration, cell biology, molecular biology, animal models, and vascular biology. The UCSD Department of Ophthalmology has a long tradition of excellence in glaucoma and retina research. With the recent recruitment of seven additional NEI funded investigators (Drs. Ayyagari, La Spada, Lin, Ju, Zhang, and most recently Balasubramanian and Huberman), vision research at UCSD has reached a critical mass that will benefit from an infrastructure to coordinate, enhance and leverage the expertise of each participating investigator to benefit the entire UCSD vision research community. Currently, 9 NEI funded investigators have offices and laboratories in the adjacent and interconnected Shiley Eye Center (SEC), Hamilton Glaucoma Center (HGC) and Jacobs Retina Center (HRC). The two adjoining research centers (Hamilton Glaucoma Center and Jacobs Retina Center) comprise 26,000 sq ft of dedicated research and office space. The SEC also provides extensive computer/IT support, and independent medical record services, as well as houses an auditorium and library. Another 6 NEI-funded investigators have offices nearby (less than a 5 minute drive from the Dept of Ophthalmology) at the main UCSD campus and adjoining Health Sciences research complex. The main campus includes vision researchers from the Depts. of Psychology (Dr. MacLeod), Biology(Dr. Rainegel), Neuroscience (Dr. Huberman) and Bioengineering (Dr. Silva). The Health Sciences complex includes the Institute for Genomic Medicine, Skaggs Pharmaceutical Sciences Building (Drs. Zhang and La Spada), the Division of Biostatistics and Bioinformatics and Biostatistics Research Center (BRC) in the Department of Family and Preventive Medicine (Dr. Jain) and the Basic Science Building-BSB with adjoining Medical Teaching Facility-MTF which house the animal care facilities and animal laboratories of Drs. Lin, Ju, Freeman, Bartsch, and Weinreb. Moreover, the UCSD Vision Research Core will leverage the unique engineering and computational expertise of UCSD's Center for Computational Sciences, Mathematics, and Engineering¿CSME training initiative. Computer Science (Prof David Kriegman) and Math Department (Prof Michael Hoist - see letter of support), the California Institute of Telecommunications and Information Technology (CALIT2- whose mandate is to enhance the "collaborative research environment for the digital future" for details see http://www.calit2.net/) (Prof Larry Smarr- see letter of support), and the resources of the San Diego Supercomputer Center to enhance current research endeavors and extend existing collaborations (e.g., Glaucoma-Math-Calit2 collaboration) to the broader vision research community. The overall purpose of this application is to provide shared resources to enhance and accelerate the productivity of the vision research community at UCSD. The following 4 modules will provide important new resources and services that are currently unavailable or difficult for each investigator to obtain individually. Each module has either 2 Co-Directors (each with NEI ROI funding), or a Director and Assistant Director (with specific expertise valuable to the module) to ensure administrative coverage so that issues can be addressed in a timely manner regardless of travel or other commitments by one of the Directors. In addition, the personnel for each module will both provide direct services (e.g. statistical analyses, computer programming, histology) and also train investigators and their staff to complete tasks so that module resources are utilized as efficiently as possible for maximum productivity.

描述（由申请人提供）：加州大学圣地亚哥分校 (UCSD) 视觉研究核心拨款提案将在 4 个不同的实质性领域提供关键资源，以利用 NEI 资助的 UCSD 研究人员的专业知识，并加速 NIH 资助的研究的发现。 15 位研究人员总共有 18 个 NEI 资助的合格 R01 项目，这些研究人员来自 UCSD 眼科、病理学、儿科、基因组医学研究所、放射学和医学研究所。心理学代表了一个令人印象深刻、富有成效和团结的视觉研究人员群体，UCSD 视觉研究人员涵盖了各个级别的教职人员任命和研究成就，从 9 名在各自领域处于领先地位的正教授到 6 名最近招聘的初级教员（Annese 博士、 Balasubramanian、Bosworth、Huberman、Ju、Lin）此外，来自其他 NIH 研究所和基金会的大量资金（表 2）进一步凸显了 UCSD 视觉研究项目的实力。人类和动物成像和功能评估、图像分析、流行病学/临床研究、遗传学、青光眼、AMD、视网膜变性、细胞生物学、分子生物学、动物模型和血管生物学。加州大学圣地亚哥分校眼科在青光眼和视网膜研究方面有着悠久的卓越传统，最近又招募了七名 NEI 资助的研究人员（Ayyagari 博士、La Spada 博士、Lin 博士、Ju 博士、Zhang 博士以及最近的 Balasubramanian 博士和 Huberman 博士），视力。加州大学圣地亚哥分校的研究已经达到了临界规模，这将受益于协调、增强和利用每位参与研究人员的专业知识的基础设施，从而使整个加州大学圣地亚哥分校视觉研究界受益。目前，有 9 名 NEI 资助的研究人员已获得资助。相邻且相互连接的希利眼科中心 (SEC)、汉密尔顿青光眼中心 (HGC) 和雅各布斯视网膜中心 (HRC) 的办公室和实验室这两个相邻的研究中心（汉密尔顿青光眼中心和雅各布斯视网膜中心）拥有 26,000 平方英尺的专门研究室。 SEC 还提供广泛的计算机/IT 支持和独立的医疗记录服务，并设有礼堂和图书馆，另有 6 名 NEI 资助的调查员设有办公室。位于加州大学圣地亚哥分校主校区附近（距眼科不到 5 分钟车程）和毗邻的健康科学研究中心。主校区包括来自心理学系（MacLeod 博士）、生物学系（Rainegel 博士）的视觉研究人员。、神经科学（Huberman 博士）和生物工程（Silva 博士）健康科学综合体包括基因组医学研究所、Skaggs 制药科学大楼（Zhang 博士和 La Spada 博士）、家庭和预防医学系（Jain 博士）的生物统计和生物信息学和生物统计研究中心（BRC）以及基础科学大楼 - BSB 以及毗邻的医学教学设施 - MTF，其中设有 Lin 博士的动物护理设施和动物实验室。、Ju、Freeman、Bartsch 和 Weinreb 此外，UCSD 视觉研究核心将利用 UCSD 计算科学中心、数学、和工程¿ CSME 培训计划。计算机科学（David Kriegman 教授）和数学系（Michael Hoist 教授 - 参见支持信）、加州电信和信息技术研究所 (CALIT2)，其任务是增强“数字未来的协作研究环境”。 “ ”了解详细信息，请参见 http://www.calit2.net/）（Larry Smarr 教授 - 请参见支持信），以及圣地亚哥超级计算机中心的资源，以加强当前的研究工作并扩展现有的合作（例如，Glaucoma-Math-Calit2 合作）面向更广泛的视觉研究社区。此应用程序的总体目的是提供共享资源，以提高和加速 UCSD 视觉研究社区的生产力。以下 4 个模块将提供重要的新功能。目前每个研究者无法获得或难以单独获得的资源和服务每个模块都有 2 名联合主任（每位均由 NEI ROI 资助），或一名主任和助理主任（具有对该模块有价值的特定专业知识），以确保行政管理。覆盖范围，以便问题能够无论一位主任是否出差或有其他承诺，都可以及时解决这些问题。此外，每个模块的人员将提供直接服务（例如统计分析、计算机编程、组织学），并培训研究人员及其工作人员完成。任务，以便尽可能有效地利用模块资源，从而实现最大生产力。