Frontiers in Aging and Regeneration Research (FrARR)

衰老与再生研究前沿 (FrARR)

• 批准号: 8723039
• 负责人: GERALD SCHATTEN
• 金额: $ 37.63万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723039
• 关键词: Achievement; African American; Aging; Alzheimer' s Disease; Americas; Animal Welfare; Area; Authorship; Award; Biology of Aging; Caenorhabditis elegans; Cell model; Chromatin; Clinical Research; Collaborations; Commit; Communities; Conflict of Interest; DNA Repair; Development; Disease; Drosophila genus; Education; Educational workshop; Emotional; Ensure; Environmental Protection; Epigenetic Process; Ethics; Ethnic Origin; Faculty; Forensic Medicine; Fostering; Fraud; Funding; Goals; Historically Black Colleges and Universities; Human; Industry; Institution; Investigation; Investments; Ireland; Kale - dietary; Laboratories; Lamins; Legal; Legal patent; Longevity; Mentors; Mentorship; Methods; Mind; Mission; Mitochondria; Modeling; Monitor; Mus; Natural regeneration; Nerve Degeneration; Neurobiology; Oral; Organelles; Osteoporosis; Participant; Primates; Process; Professional counselor; Progeria; Publications; Race; Regenerative Medicine; Research; Research Personnel; Research Project Grants; Research Support; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Series; Social isolation; Staging; Stem cells; Students; Technology; Telomerase; Testing; Training; United States National Institutes of Health; Universities; Whistleblowing; Wood material; bone aging; career; career development; cost effective; design; empowered; frontier; health disparity; human embryonic stem cell; improved; interest; lecturer; minority health; muscle aging; neurogenesis; peer; posters; programs; reproductive; response; responsible research conduct; sarcopenia; senescence; social; symposium; telomere

DESCRIPTION (provided by applicant): This R25 research education application entitled: 'Frontiers in Aging and Regenerative Medicine (FrARR),' responsive to PAR-12-016, trains and mentors promising junior and senior undergraduates from predominately underrepresented communities in sophisticated aging research, and encourages and supports them as they embark on graduate studies. FrARR offers: first, dynamic training courses, then nurtured Mentor-Trainee partnerships enhanced by guidance from Senior Mentors and peer-peer mentoring, enriched by annual symposia and scientific retreats, with quantitative tracking of career trajectories. The courses are offered at HBCU institutions, i.e. Xavier University (years 1 & 4), Morehouse (years 2 & 5) and Meharry (year 3), under the overall directorship of Gerald Schatten (Pittsburgh) and S. Michael Jazwinski (Tulane), with Shubha Kale Ireland (Xavier), Winston Thompson (Morehouse), and Ayman Al-Hendy (Meharry). Our Advisory Board of Scientific Counselors, composed of acclaimed experts in the fields of aging, regeneration and health disparities, oversee this initiative. The five specific aims are: I. Engendering the enthusiasm, passions and commitments to scientific careers embraced by the faculty provides intellectual and emotional underpinnings for supporting undergraduate trainees as they complete their MSTEM degrees. This is accomplished via conceptual education and laboratory training, focused on diseases and disorders relevant to aging and African- American communities. Didactic training includes: A. Biology of Aging and Stem Cell Models; B. Neurobiology of Aging and Alzheimer's disease; C. Muscle and Bone Aging; D. Reproductive Aging; and E. Epigenetics and Environmental Modulators of Aging, along with complementary labs. II. Fostering candid regarding current barriers to the recruitment and retention of our most talented researchers and training in responsible conduct of research, ethical, legal and societal implications, and especially problems of minority health disparities in research. III. Motivate, Enable and Sustain Trainees as they transition to professional careers, with mentored research projects and on-going career advice. Enhance their growing interests by their presentations at the Annual Reunion Symposia at Woods Hole contemporaneously with the MBL's Aging Course. Course alumni provide peer-peer mentorship. IV. Encouraging and empowering trainees and alumni by guiding them through the graduate application and matriculation processes so that they are rapidly and smoothly able to initiate doctoral studies in aging research and regenerative medicine. V. Evaluate, Improve and Monitor FrARR's strengths and avoid weaknesses with quantitative independent mechanisms, track trainees' achievements comprehensively and longitudinally, to ensure that these precious funds can be quantitatively demonstrated as wise, cost-effective and fruitful investments. In summary, our overall goals are to provide comprehensive sophisticated training in research strategies and career launching for underrepresented trainees to advance the scientific workforce pioneering the Frontiers in Aging and Regenerative Medicine.

描述（由申请人提供）：这个 R25 研究教育应用程序题为“衰老和再生医学前沿 (FrARR)”，响应 PAR-12-016，培训和指导来自在复杂的衰老研究中代表性不足的社区的有前途的初三和高年级本科生，并鼓励和支持他们开始研究生学习。 FrARR 提供：首先是动态培训课程，然后通过高级导师和同行指导的指导来培养导师与实习生的伙伴关系，通过年度研讨会和科学务虚会来丰富内容，并对职业轨迹进行定量跟踪。这些课程由 HBCU 机构提供，即 Xavier University（1 年级和 4 年级）、Morehouse（2 年级和 5 年级）和 Meharry（3 年级），由 Gerald Schatten（匹兹堡）和 S. Michael Jazwinski（杜兰大学）全面负责，与 Shubha Kale Ireland (Xavier)、Winston Thompson (Morehouse) 和 Ayman Al-Hendy (Meharry) 一起。我们的科学顾问顾问委员会由衰老、再生和健康差异领域的知名专家组成，负责监督这一举措。这五个具体目标是： I. 激发教师对科学事业的热情、热情和承诺，为支持本科生完成 MSTEM 学位提供智力和情感基础。这是通过概念教育和实验室培训来实现的，重点关注与老龄化和非裔美国人社区相关的疾病和失调。教学培训包括： A. 衰老生物学和干细胞模型； B. 衰老和阿尔茨海默病的神经生物学； C. 肌肉和骨骼老化； D. 生殖衰老； E. 表观遗传学和衰老环境调节剂，以及补充实验室。二.坦诚地对待当前招募和保留最有才华的研究人员以及负责任的研究行为培训方面的障碍，道德、法律和社会影响，特别是研究中少数族裔健康差异的问题。三．通过指导研究项目和持续的职业建议，在学员过渡到职业生涯时激励、支持和支持他们。通过在伍兹霍尔举行的年度聚会研讨会上与 MBL 老龄化课程同时进行的演讲，增强他们日益增长的兴趣。课程校友提供同伴指导。四．通过指导学员和校友完成研究生申请和入学流程，鼓励和赋予他们权力，使他们能够快速、顺利地启动衰老研究和再生医学的博士研究。五、以量化的独立机制评估、改进和监控FrARR的优势、扬长避短，全面纵向跟踪学员的成果，确保这些宝贵的资金能够量化地体现为明智的、经济的、富有成效的投资。总之，我们的总体目标是为代表性不足的学员提供研究策略和职业启动方面的全面、复杂的培训，以促进开拓衰老和再生医学前沿的科学队伍。