Quantitative 3D Diffusion and Relaxometry MRI of the Knee

膝关节定量 3D 扩散和松弛测量 MRI

基本信息

批准号：
8926355
负责人：
Brian Andrew Hargreaves
金额：
$ 50.42万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-09 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8926355
关键词：
Affect Biochemical Biomechanics Boston Cartilage Clinical Clinical Research Collagen Control Groups Data Analyses Degenerative polyarthritis Development Diagnostic Diagnostic Imaging Diagnostic radiologic examination Diffusion Disease Disease Progression Evaluation Functional Imaging Goals Health Histologic Histology Human Image Imaging Techniques Imaging technology Injection of therapeutic agent Joints Knee Knee Injuries Knee Osteoarthritis Knee joint Logistics Magnetic Resonance Imaging Maps Measurement Measures Mechanics Meniscus structure of joint Methods Minor Modeling Modification Morphologic artifacts Morphology Operative Surgical Procedures Orthopedic Surgery procedures Orthopedics Patients Population Process Property Proteoglycan Protocols documentation Quality of life Research Resolution Risk Sampling Scanning Specific qualifier value Specificity Specimen Staging Structure Synovial Membrane Synovitis Techniques Testing Thick Three-Dimensional Imaging Time Tissue Sample Tissues Water Work anterior cruciate ligament rupture base clinically relevant collaborative environment cost cost effective disability high risk imaging modality in vivo innovation novel quantitative imaging response tissue resource water diffusion

项目摘要

DESCRIPTION (provided by applicant): Osteoarthritis (OA) affects over half the population at some point in their lives, yet treatment options and understanding of OA remain limited, in part due to limited availability of non-invasive techniques to quantify disease progression and responses to therapies. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, they all have at least one major limitation, ranging from long scan times to limited specificity. We propose a new MRI technique called quantitative double-echo in steady-state (qDESS) imaging that simultaneously offers 3D morphologic and functional imaging of the entire knee, including water diffusion and rapid relaxometry measurements. This project aims to fully develop qDESS so that it may be widely used, then to assess the value of quantitative diffusion and relaxometry measures in cartilage and menisci to detect early and temporal changes. Our specific aims are (1) to develop a robust scanning sequence and accompanying post-processing methods to obtain high-resolution 3D maps of apparent diffusion coefficient (ADC), T2 and T2* in a 10-minute scan at 3T, (2) to validate this technique with imaging of excised human samples, comparing quantitative imaging parameters with biochemical, histological and mechanical metrics in cartilage and menisci to determine sensitivity to tissue degeneration, and (3) to validate the ability of qDESS to detect changes over time in the knees of subjects at risk of developing OA following anterior cruciate ligament (ACL) tears. The innovation of this work lies in the development of a clinically feasible technique that simultaneously offers (1) morphologic images that can potentially be used for whole-knee scoring and radiologic assessment and (2) quantitative parameters in both cartilage and meniscus including volume and thickness measurements, T2 and T2* maps and ADC maps, and (3) a non-contrast-enhanced method to assess synovitis. The significance of this proposal is to offer a widely available, quantitatively validated 10-minute imaging method that makes comprehensive routine study of early osteoarthritis feasible in both research and clinical MRI exams.

描述（由申请人提供）：骨关节炎 (OA) 在一生中的某个阶段影响超过一半的人口，但治疗选择和对 OA 的了解仍然有限，部分原因是量化疾病进展和反应的非侵入性技术有限。到治疗。虽然已经提出了多种用于 OA 成像的磁共振成像 (MRI) 方法，但它们都至少有一个主要限制，从扫描时间长到特异性有限。我们提出了一种称为稳态定量双回波 (qDESS) 成像的新 MRI 技术，该技术可同时提供整个膝盖的 3D 形态和功能成像，包括水扩散和快速松弛测量。该项目旨在充分开发 qDESS 以便其得到广泛应用，然后评估软骨和半月板中定量扩散和松弛测量的价值，以检测早期和时间变化。我们的具体目标是 (1) 开发强大的扫描序列和随附的后处理方法，以便在 3T 的 10 分钟扫描中获得表观扩散系数 (ADC)、T2 和 T2* 的高分辨率 3D 图，(2)通过对人体切除样本进行成像来验证该技术，将定量成像参数与软骨和半月板的生化、组织学和机械指标进行比较，以确定对组织变性的敏感性，以及 (3) 验证 qDESS 检测变化的能力随着时间的推移，前十字韧带 (ACL) 撕裂后有发生 OA 风险的受试者的膝盖会受到影响。这项工作的创新之处在于开发了临床可行的技术同时提供 (1) 可用于全膝评分和放射学评估的形态学图像，以及 (2) 软骨和半月板的定量参数，包括体积和厚度测量、T2 和 T2* 图以及 ADC 图，以及 (3 ）一种评估滑膜炎的非对比增强方法。该提案的意义在于提供一种广泛可用、经过定量验证的 10 分钟成像方法，使早期骨关节炎的全面常规研究在研究和临床 MRI 检查中变得可行。