Cardiovascular Health After Placental Abruption (CHAP)

胎盘早剥后的心血管健康 (CHAP)

基本信息

批准号：
10677792
负责人：
Cande V. Ananth
金额：
$ 69.74万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-13 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677792
关键词：
Abruptio Placentae Acute Acute myocardial infarction Address Adult Affect Arteries Attention Birth Cardiovascular Diagnostic Techniques Cardiovascular Diseases Cardiovascular system Cerebrovascular Disorders Cessation of life Characteristics Child Child Health Chronic Disease Classification Clinical Congestive Heart Failure Data Databases Discipline of obstetrics Disease Educational workshop Ethnic Origin Etiology Event Fetal Death Fetal Growth Retardation Frequencies Future Gestational Age Gestational Diabetes Goals Health Policy Hemorrhage High Risk Woman Hospitalization Infant Health Infant Mortality Inflammation Ischemia Life Link Live Birth Machine Learning Maternal-Fetal Exchange Measures Mediating Mediation Medical Morbidity - disease rate Myocardial Infarction Myocardial Ischemia National Heart, Lung, and Blood Institute National Institute of Child Health and Human Development New Jersey Newborn Infant Outcome Oxidative Stress Patient Admission Perinatal Perinatal mortality demographics Placenta Pre-Eclampsia Predisposition Pregnancy Pregnancy Complications Premature Birth Public Health Pulmonary Embolism Race Recommendation Recurrence Reporting Risk Risk Factors Rupture Sentinel Severities Small for Gestational Age Infant Socioeconomic Status Stimulus Stroke System Twin Multiple Birth United States National Institutes of Health Uterus Vision Woman Women&apos s Health acute care cardiovascular disorder risk cardiovascular health cardiovascular risk factor cerebrovascular comorbidity data acquisition deep learning algorithm epidemiology study follow-up health of the mother high risk hospital care hypertensive heart disease improved infant death insight interest maternal cigarette smoking maternal risk mortality obstetrical complication policy implication population based premature screening guidelines sociodemographics stillbirth support vector machine thrombotic

项目摘要

Abstract Placental abruption is an obstetrical complication defined as premature placental separation. Despite its elusive etiology, it is believed to be the consequence of acute stimuli – ischemia, inflammation, and oxidative stress at the maternal‐fetal interface – associated with rupture of the decidual artery, resulting in (premature) placental separation. The study of abruption and maternal and newborn long‐term cardiovascular and hemorrhagic/thrombotic cerebrovascular events is the central focus of the proposed project. We will examine the long‐term impact of abruption on rates of cardiovascular and cerebrovascular morbidity and mortality in women and in their children. We will also investigate the relationship of clinical classification (mild and severe forms) of abruption, risks based on abruption across successive pregnancies, and abruption in twin pregnancies, on rates of cardiovascular and cerebrovascular events. We will undertake a causal mediation analysis to evaluate the extent to which these associations may be mediated through (i) preterm delivery and (ii) small for gestational age births. We will perform this analysis by clinical classification of abruption and estimate the extent of mediation following corrections for both measured (socio‐demographic characteristics, including maternal smoking, comorbid medical conditions, and obstetrical events), and unmeasured confounding. A unique aspect of this project will be to identify, through applications of Support Vector Machines and Deep Learning algorithms, subsets of women at high risk for abruption and cardiovascular and cerebrovascular mortality and morbidity. Finally, we will examine whether maternal race/ethnicity and socioeconomic status are effect measure modifiers of the association between abruption and risks of cardiovascular and cerebrovascular events. We propose to address these aims through a large population‐based epidemiologic study, utilizing data from the Myocardial Infarction Data Acquisition System (MIDAS), a New Jersey statewide database of all patients admitted to all non‐federal acute care hospitals in NJ with a CVD diagnosis, with longitudinal follow‐up of up to 30 years. The MIDAS data will be linked to the NJ fetal death and linked live birth‐ infant death data with associated maternal and newborn hospitalization data between 1980‐2017 to create one of the largest and most comprehensive databases in the US to evaluate the extent to which sentinel events in pregnancy impart lasting risk for women's and children's health later in life. This project will provide unprecedented opportunities to address public health, policy implications and clinical screening recommendations of women during the period following delivery regarding risk susceptibility to cardiovascular and cerebrovascular disease.

抽象的胎盘破裂是一种产科汇编，被定义为预言。它被认为是母亲 - fetal- fetal的急性刺激，炎症和氧化应激的疾病。界面 - 与十字内动脉的破裂相关，导致（预先）胎盘分离。出现，母亲和新生儿长期心血管和出血/血栓性脑血管事件是IS IS IS IS ISTE 拟议项目的主要重点。妇女及其子女的脑血管发病率和刻度。临床分类（轻度和严重形式）的破裂，基于连续的前提的突发性和饮食的风险。双胞胎怀孕的突发事件，关于心血管和脑血管事件的发生率。调解分析以评估通过（i）早产和（ii）胎龄小的小。对两个测量的校正后的调解程度吸烟，合并医疗状况和产科事件）和独特的ASURED困惑。通过支持向量机和深度学习算法的应用，可以识别项目妇女出现高风险，心血管和脑血管死亡率和发病率。孕产妇种族/种族和社会经济地位是否是介于两者之间的选择心血管和脑血管事件的破坏和风险。基于人群的流行病学研究，利用心肌梗塞数据采集系统（ADA）的数据，A 新泽西州全州范围内的所有患者的数据库，他们接受了CVD诊断的所有非联邦急诊医院旅馆，纵向跟随 - 最多30年。婴儿数据与1980 - 2017年之间的相关孕妇和新生医院数据相关的数据，以创建其中之一美国最大，最大的补偿数据库，以评估哨兵事件在怀孕期间的程度妇女和儿童健康的持续风险在以后的生活中。公共卫生，政策含义和清洁筛查推荐妇女在交货后的期间推荐接收关于对心血管和脑血管疾病的风险敏感性。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.

2019 早期冠状病毒病的限制措施和孕产妇特征的变化、辅助生殖技术的使用和死产。

DOI：
10.1111/ppe.12925
发表时间：
2023
期刊：
Paediatric and perinatal epidemiology
影响因子：
2.8
作者：
Lisonkova,Sarka;Bone,JeffreyN;Muraca,GiuliaM;Razaz,Neda;Boutin,Amelie;Brandt,JustinS;Bedaiwy,MohamedA;Ananth,CandeV;Joseph,KS
通讯作者：
Joseph,KS

Obstetric Intervention and Perinatal Outcomes During the Coronavirus Disease 2019 (COVID-19) Pandemic.

DOI：
10.1097/aog.0000000000005412
发表时间：
2023-12-01
期刊：
Obstetrics and gynecology
影响因子：
7.2
作者：
通讯作者：

Enriched Random Forest for High Dimensional Genomic Data.

DOI：
10.1109/tcbb.2021.3089417
发表时间：
2022-09
期刊：
IEEE/ACM transactions on computational biology and bioinformatics
影响因子：
0
作者：
通讯作者：

Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population-based study.

DOI：
10.1111/1471-0528.16932
发表时间：
2022-03
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
0
作者：
通讯作者：

Assessment of one-year risk of ischemic stroke versus major bleeding in patients with atrial fibrillation.

DOI：
10.1016/j.ijcrp.2022.200129
发表时间：
2022-06
期刊：
International journal of cardiology. Cardiovascular risk and prevention
影响因子：
0
作者：
Sargsyan D;Cabrera J;Duan Y;Ananth CV;Kostis WJ;Kostis JB;Myocardial Infarction Data Acquisition System (MIDAS-42) Study Group
通讯作者：
Myocardial Infarction Data Acquisition System (MIDAS-42) Study Group