Biodegradable, Biocompatible Pressure Sensitive Adhesives

可生物降解、生物相容性压敏粘合剂

• 批准号: 10677869
• 负责人: Yolonda L Colson
• 金额: $ 52.05万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-05 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677869
• 关键词: Acrylates; Adherence; Adhesions; Adhesives; Air; Air Movements; Alveolar; Bacteria; Bacterial Infections; Bandage; Benign; Biocompatible Materials; Bronchial Injury; Bypass; Carbon Dioxide; Carbonates; Cessation of life; Chemical Structure; Clinical; Collaborations; Collagen; Data; Duct (organ) structure; Endothelium; Epithelium; Ethanol; Evaluation; Excision; Exhibits; Experimental Designs; Family suidae; Fibroblasts; Fistula; Formulation; Glass; Glyceric Acids; Glycerol; Guidelines; Health Care Costs; Human; Hydrophobicity; In Vitro; Infection; Injury; Libraries; Liquid substance; Lung; Macrophage; Medical; Medical Device Safety; Metals; Modeling; Molecular Weight; Morbidity - disease rate; Mus; Muscle; Oligonucleotides; Operative Surgical Procedures; Oral; Paper; Patient Care; Performance; Pleural; Pleural cavity; Polymers; Prevention; Procedures; Property; Pulmonary valve structure; Respiration; Respiratory physiology; Secure; Series; Steel; Structure; Structure of parenchyma of lung; Surface; Surgical Staplers; Surgical sutures; Testing; Thoracic Surgical Procedures; Tissues; Wood material; biocompatible polymer; biomaterial compatibility; cancer invasiveness; comparative; cytotoxicity; ethylene glycol; experimental study; functional mimics; healing; implantation; improved; in vivo; in vivo Model; innovative technologies; lung injury; mechanical behavior; migration; mortality; novel; organ injury; poly(lactide); polyacrylate; porcine model; pressure; prevent; repaired; response; seal; sealant; wound

PROJECT SUMMARY/ABSTRACT * This proposal describes new biodegradable, biocompatible pressure sensitive adhesives (PSAs) with tunable adhesion strength for in vivo use. Thus, this innovative technology overcomes the limitation of current PSAs which are only used topically and broadens the scope of applications of such biomaterials in patient care. To highlight the utility of these new PSAs, we identified two significant and problematic clinical procedures in thoracic surgery associated with increases in health care costs and high mortality rates: the repair of alveolar- and broncho- pleural fistulae. Today, closure of such leaks is challenging due to use in a contained space and to an inherent pressure gradient across the fistula. Survival is directly related to successful fistula closure and prevention of pleural infection through the fistula. Specifically, we are evaluating novel poly(1,2-glyceric acid carbonate)s and poly(1,2-glycerol carbonate)s (PGCs) which functionally mimic conventional polyacrylate PSAs but possess biodegradable carbonate linkages and degrade into benign products – e.g., glycerol, CO2, ethanol. These first-of-their-kind polymers provide an opportunity to create a new class of PSAs and shift the paradigm around our ability to control and manage intrathoracic wounds. The proposed experiments will test the hy- potheses that these PGC based pressure sensitive adhesives will: 1) exhibit compositionally dependent adhesive strength which positively correlates with greater molecular weight, longer alkyl chains, and stereoregularity; 2) display peel strengths which can be tuned over a wide range from Post-it® note to Duct® Tape like performance; and, 3) enable securing a collagen buttress to a surgical stapler or an electrospun polylactide mesh patch for sealing lung and bronchial injuries. Importantly, preliminary data support these hypotheses, and well-characterized materials and rigorous experimental designs are established in this proposal with essential cross-disciplinary collaborations and expertise. The specific aims of this five-year proposal are: Aim 1. Synthesize and characterize a series of PGC-based pressure sensitive adhesives; Aim 2. Evaluate the compatibility of the PGC-adhesive collagen and PLA patch in vitro and in vivo, and inhibition of bacteria migration in vitro; and, Aim 3. Evaluate the performance of the PGC-adhesive collagen and PLA patch in an in vivo porcine model.

项目摘要/摘要 *该提案描述了新的可生物降解的可生物相容性压力敏感粘合剂（PSA） 可调节的粘附强度用于体内使用。这是这种创新技术克服了当前的局限性 PSA仅局部使用并扩大了此类生物材料在患者护理中的应用范围。 为了强调这些新PSA的实用性，我们确定了两个重要的有问题的临床程序 与医疗保健成本增加和高死亡率相关的胸外科手术：肺泡的修复 和支气管肿瘤瘘。如今，由于在包含的空间中使用，这种泄漏的关闭是具有挑战性的 在整个瘘管上继承压力梯度。生存与成功的瘘管闭合直接相关 通过瘘管预防胸膜感染。特别是，我们正在评估新型聚（1,2-糖酸） 碳酸盐）S和Poly（1,2-甘油碳酸盐）S（PGC），在功能上模仿常规聚丙烯酸酯psas 但具有可生物降解的碳酸盐键并降解为良性产品，例如甘油，二氧化碳，乙醇。 这些第一届的聚合物提供了创建新类PSA并改变范式的机会 围绕我们控制和管理胸腔内伤口的能力。提出的实验将测试Hy- 这些基于这些基于PGC的压力敏感粘合剂将：1）裸露的综合依赖 粘附强度与更大的分子量，更长的烷基链和 立体观念； 2）显示果皮强度，可以在tost-it®注释中调整为广泛的范围 Duct®胶带喜欢性能； 3）启用将胶原蛋白支撑固定到手术订书机或 用于密封肺和支气管损伤的静电乳酰胺乳清斑块。重要的是，初步数据 支持这些假设，并且建立了良好的材料和严格的实验设计 在本提案中，具有基本的跨学科合作和专业知识。这个五年的具体目标 建议是：目标1。合成和表征一系列基于PGC的压力敏感胶粘剂；目标2。 评估PGC粘附胶原蛋白和PLA斑块在体外和体内的兼容性，并抑制 细菌体外迁移；以及AIM 3。评估PGC粘合剂胶原蛋白和PLA斑块的性能 在体内猪模型中。