Establishing the Relationship Between Muscle Quality and Joint Loading for Individuals with Transtibial Amputation

建立小腿截肢患者的肌肉质量和关节负荷之间的关系

基本信息

批准号：
10677236
负责人：
Meredith Owen
金额：
$ 6.91万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-24 至 2026-04-23
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677236
关键词：
Activities of Daily Living Affect Amputation Anisotropy Award Biomechanics Biomedical Engineering Clinical Research Collaborations Computer Models Data Degenerative polyarthritis Development Devices Diffusion Magnetic Resonance Imaging Educational workshop Environment Evaluation Event Fellowship Fiber Fibrosis Foundations Functional disorder Future Gait Goals Grant Health Image Imaging Techniques Individual Infiltration Injury Institution Intervention Isometric Exercise Joints Kinetics Knee Knee joint Length Life Limb structure Lower Extremity Magnetic Resonance Imaging Maps Measures Mechanics Medical Imaging Mentors Mentorship Modeling Morphology Motion Movement Muscle Muscle Fibers Muscle function Musculoskeletal National Research Service Awards Orthopedics Outcome Participant Patient Self-Report Postdoctoral Fellow Property Quality of life Relaxation Research Personnel Risk Scientist Side Statistical Data Interpretation Surveys Technical Expertise Techniques Testing Thigh structure Time Tissues Training United States Walking Work Writing career career development clinically relevant design functional improvement functional outcomes image processing improved insight instrument joint loading kinematics limb amputation limb loss long-term sequelae loss of function muscle strength novel novel imaging technique novel therapeutic intervention prosthesis wearer prosthetic socket quadriceps muscle research data dissemination residual limb skill acquisition skills statistics success translational scientist

项目摘要

ABSTRACT The loss of function following an amputation is profound and life altering. To date, interventions to improve long term functional abilities and limit detrimental secondary injuries (e.g. osteoarthritis) have not been effective. While multifactorial, the effect of altered muscle quality, specifically of the quadriceps, on functional outcomes for individuals with transtibial amputation is poorly understood. Work by our group in other conditions shows that muscle quality changes after injury and is directly related to loss of function, including protracted strength deficits. My long-term career goal is to combine my background in bioengineering with the skills developed through this F32 training grant to develop novel therapeutic strategies and devices to improve function and quality of life for individuals with lower limb loss. This training award will allow me to 1) assess the muscle quality of the thigh of the intact and residual limbs with novel magnetic resonance imaging sequences, 2) predict the relationship between thigh muscle quality and muscle strength, and finally 3) characterize the relationship between muscle quality, muscle strength, and knee joint loading for individuals with transtibial amputation. Muscle quality will be assessed using novel magnetic resonance imaging techniques including T1rho mapping and diffusion tensor imaging. These techniques will provide new insights on the muscle tissue morphology, including any increases in fibrotic tissue or decreases in pennation angle and fiber tract length, that affect the muscle's overall ability to function properly and efficiently. To evaluate muscle strength and mobility, participants will complete maximum voluntary isometric knee flexion and validated surveys targeting self-reported mobility. Finally, joint contact forces of the intact limb will be assessed through a computational musculoskeletal model. Through the work proposed for this NRSA F32, I will refine and gain skills critical for a successful career as an independent translational researcher seeking to collaborate with clinician scientists. Training will include skills development in medical imaging acquisition and analysis, clinically relevant strength assessment, instrumented motion analysis, musculoskeletal modeling, clinical research management, and statistical analysis. Including in the training plan are accessory career development activities including related course work (e.g. biomechanics, statistics, medical imaging), grant writing workshops, opportunities for research dissemination, and mentorship that will all be key components to developing a well-rounded skill set for a future academic career. My selected sponsor, institution, and mentors will provide the perfect environment for encouraging success.

抽象的截肢后的功能丧失是深刻的，并且改变了生活。迄今为止，干预措施以改善长时间术语功能能力和限制有害的继发损伤（例如骨关节炎）尚未有效。虽然多因素，但肌肉质量改变的影响，特别是股四头肌的影响，对功能结果对于纵横截肢的个体，人们了解得很糟糕。我们小组在其他情况下工作受伤后的肌肉质量变化，与功能丧失直接相关，包括持久的强度缺陷。我的长期职业目标是将我的生物工程背景与发展的技能相结合通过这项F32培训赠款，以制定新颖的治疗策略和设备，以改善功能和下肢损失的个体的生活质量。该培训奖将使我允许1）评估肌肉具有新的磁共振成像序列的完整和残留四肢大腿的质量，2）预测大腿肌肉质量和肌肉力量之间的关系，最后3）表征肌肉质量，肌肉力量和膝关节负荷之间的关系截肢。将使用新型的磁共振成像技术评估肌肉质量 T1RHO映射和扩散张量成像。这些技术将为肌肉组织提供新的见解形态，包括纤维化组织的任何增加或销钉角度下降，纤维道的长度，这会影响肌肉正常运作的整体能力。评估肌肉力量和流动性，参与者将完成最大的自愿等距膝关节屈曲并进行验证的靶向调查自我报告的流动性。最后，完整肢体的联合接触力将通过计算评估肌肉骨骼模型。通过为这项NRSA F32提出的工作，我将完善并获得技巧至关重要作为一名独立翻译研究人员的成功职业，试图与临床医生合作。培训将包括医学成像获取和分析的技能开发，临床相关的力量评估，仪器运动分析，肌肉骨骼建模，临床研究管理和统计分析。包括在培训计划中包括附属职业发展活动，包括相关课程工作（例如生物力学，统计，医学成像），授予写作讲习班，机会研究传播和指导都将是发展全面技能的关键组成部分为了未来的学术职业。我选择的赞助商，机构和导师将提供完美的鼓励成功的环境。