Head and Neck Cancer SPORE at the University of Wisconsin

威斯康星大学头颈癌孢子

基本信息

批准号：
10673937
负责人：
PAUL M HARARI
金额：
$ 202.11万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-02 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673937
关键词：
Anatomy Animal Model Appearance Biological Markers Biological Models Biomedical Engineering Biometry Blood Vessels Breathing Cancer Patient Cells Clinical Clinical Research Clinical Trials Collaborations Complex Data Data Set Deglutition Development Diagnosis Disease Family Fibroblasts Future Goals Grant Head and Neck Cancer Head and neck structure Immune Immune response Immunologics Industry Laboratory Research Laboratory Study Link Location Lymphatic Malignant Neoplasms Mediating Metastatic/Recurrent Modeling Morbidity - disease rate Neoplasm Metastasis Newly Diagnosed Normal tissue morphology Outcome Pathology Patient-Focused Outcomes Patients Phase I Clinical Trials Pilot Projects Play Population Postoperative Period Pre-Clinical Model Preclinical Testing Prediction of Response to Therapy Quality of life Radiation Radiation therapy Radioisotopes Radionuclide therapy Receptor Protein-Tyrosine Kinases Reproduction spores Research Research Personnel Research Project Grants Research Support Resources Role Scientist Series Social Interaction Speech Testing Therapeutic Tissue Microarray Toxic effect Translating Translational Research Translational trial Treatment-related toxicity Tumor Tissue Universities Wisconsin Work anticancer research axl receptor tyrosine kinase cancer clinical trial career career development checkpoint inhibition curative treatments design feasibility testing head and neck cancer patient immunoregulation improved improved outcome individual patient inhibitor model building multidisciplinary neoplastic cell novel oral HPV-positive head and neck cancers patient response predictive modeling programs receptor research and development response single-cell RNA sequencing success targeted delivery treatment response treatment strategy tumor tumor growth tumor microenvironment tumor-immune system interactions

项目摘要

PROJECT SUMMARY The Wisconsin Head and Neck SPORE is designed to promote translational laboratory and clinical research to improve overall outcome for patients with Head and Neck Cancer (HNC). This highly collaborative research links basic scientists with HNC clinicians to advance novel treatment strategies for this complex cancer population. These patients bear a disproportionate burden from their cancers based on the critical anatomic location of the disease for which treatment can compromise speech, swallow, and breathing function, in addition to creating significant alterations in physical appearance and capacity for social interaction. Efforts to improve cure rates must be carefully balanced with efforts to reduce treatment toxicity to enable enhanced overall quality of life for patients. The broad objectives of this SPORE are to: 1) Promote multidisciplinary translational research in HNC, 2) Improve overall survival and quality of life for patients with HNC, 3) Incorporate new predictive models to test novel HNC treatment strategies, 4) Improve understanding of how immune modulation can augment conventional and experimental treatment responses in HNC, 5) Translate promising new molecules developed at the University of Wisconsin and from Industry through preclinical testing and into HNC clinical trials. The Wisconsin HN SPORE has designed three primary research projects. Project 1 will combine targeted radionuclide therapies (TRT) with immune checkpoint inhibition (ICI) to stimulate enhanced HNC response profiles culminating in a Phase I clinical trial. Project 2 builds a powerful patient-specific bioengineered HNC model system from patient cells that incorporates components of the tumor microenvironment to more accurately predict HNC patient treatment response. The feasibility of using treatment response data from the model to inform postoperative radiation therapy will be tested in a clinical pilot study. Project 3 examines dual targeting of critical receptor tyrosine kinases Axl and MerTK to mediate changes in the immune microenvironment and thereby augment tumor response in HNC patients. The Wisconsin SPORE will support this research with three Cores (Administrative, Pathology and Biostatistics), a Career Enhancement Program and a Developmental Research Program.

项目摘要威斯康星州的头颈孢子旨在促进翻译实验室和临床研究改善头颈癌患者（HNC）的总体预后。这种高度协作的研究链接 HNC临床医生的基础科学家将为这一复杂的癌症人群推进新颖的治疗策略。这些患者根据癌症的负担不成比例的负担治疗可以损害语音，吞咽和呼吸功能的疾病，除了创造身体外观和社交互动能力的重大变化。提高治疗率的努力必须仔细平衡降低治疗毒性的努力，以提高整体生活质量患者。该孢子的广泛目标是：1）在HNC中促进多学科翻译研究， 2）改善HNC患者的总体生存和生活质量，3）合并新的预测模型以测试新型HNC治疗策略，4）提高对免疫调节如何增加的理解 HNC中的常规和实验治疗反应，5）翻译有希望的新分子在威斯康星大学，通过临床前测试以及进入HNC临床试验。这威斯康星州HN Spore设计了三个主要的研究项目。项目1将结合目标具有免疫检查点抑制（ICI）的放射性核素疗法（TRT）刺激增强的HNC反应概况在I期临床试验中达到顶点。项目2构建强大的患者特异性生物工程HNC 来自患者细胞的模型系统，将肿瘤微环境的组成部分纳入到更准确的预测HNC患者治疗反应。使用来自模型的治疗响应数据到临床试点研究将测试术后术后放射治疗。项目3检查了双重定位关键的受体酪氨酸激酶AXL和MERTK介导免疫微环境的变化和从而增加HNC患者的肿瘤反应。威斯康星州的孢子将通过三个内核（行政，病理和生物统计学），职业增强计划和发展研究计划。

项目成果

期刊论文数量（54）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Network inference with Granger causality ensembles on single-cell transcriptomics.

DOI：
10.1016/j.celrep.2022.110333
发表时间：
2022-02-08
期刊：
CELL REPORTS
影响因子：
8.8
作者：
Deshpande, Atul;Chu, Li-Fang;Stewart, Ron;Gitter, Anthony
通讯作者：
Gitter, Anthony

SLP-Perceived Technical and Patient-Centered Factors Associated with Pharyngeal High-Resolution Manometry.

DOI：
10.1007/s00455-018-9954-z
发表时间：
2019-04
期刊：
Dysphagia
影响因子：
2.6
作者：
Jones CA;Rogus-Pulia NM;Forgues AL;Orne J;Macdonald CL;Connor NP;McCulloch TM
通讯作者：
McCulloch TM

Immune Escape Strategies in Head and Neck Cancer: Evade, Resist, Inhibit, Recruit.

DOI：
10.3390/cancers16020312
发表时间：
2024-01-11
期刊：
CANCERS
影响因子：
5.2
作者：
Kostecki, Kourtney L.;Iida, Mari;Crossman, Bridget E.;Salgia, Ravi;Harari, Paul M.;Bruce, Justine Y.;Wheeler, Deric L.
通讯作者：
Wheeler, Deric L.

Theranostics and Patient-Specific Dosimetry.

治疗诊断学和患者特异性剂量测定。