Training in Immunological Mechanisms

免疫机制培训

• 批准号: 10675443
• 负责人: Michael Croft
• 金额: $ 25.73万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675443
• 关键词: Immunologics; Training

Abstract This program will train postdoctoral research scientists in immunological mechanisms related to development and treatment of Autoimmune, Inflammatory, and Infectious Disease, and Cancer. The program at La Jolla Institute for Immunology (LJI) will involve 20 faculty members from LJI whose expertise is in immune cell function that relates to diseases such as diabetes, inflammatory bowel disease, multiple sclerosis, asthma, atherosclerosis, atopic dermatitis, dengue, HIV, cytomegalovirus, tuberculosis, ebola, and immuno-oncology. Each faculty mentor is internationally recognized in the field of immunology or immunological disease and each has substantial peer-reviewed research experience and track records. The program will be open to PhD, MD, and MD/PhD scientists interested in basic and applied research of the immune system. The training program will consist of a bench research laboratory experience of 12-24 months, under the close supervision of a mentor or several mentors working on problems relevant to immunotherapy. The research backgrounds of the faculty mentors are diverse, but with common themes centered on the biology of the primary cells of the immune system, including T cells, B cells, NKT cells, macrophages, dendritic cells, neutrophils, and others. The training program will then represent an interdisciplinary approach where each trainee is exposed to cutting edge and state-of-the-art immunological techniques and systems for making fundamental and translational discoveries of the immune system. Our current and past trainees have excellent records of research accomplishments. New trainees will be recruited nationwide and efforts will be made to recruit and retain exceptional minority, women, and disadvantaged candidates. Trainees will be chosen on the basis of their prior academic performance, research experience, publications, interviews, and recommendations from supervisors. Trainees will participate in institutional seminars, journal clubs, courses, and immunology conferences designed to expand the breadth of their understanding of immunology and immunological disease. All trainees will be instructed in the principles of responsible conduct of research and scientific integrity. The goals of the program are to foster the development of well-rounded immunologists who can fill much needed academic positions, who can compete and be successful in obtaining independent research grants, and who can contribute to biotechnology and pharmaceutical approaches, aimed at treatment of immune-related diseases.

抽象的 该项目将培训博士后研究科学家，研究与发育相关的免疫机制 自身免疫性疾病、炎症性疾病、传染病以及癌症的治疗。拉霍亚的项目 免疫学研究所（LJI）将有 20 名来自 LJI 的、专长于免疫细胞的教员参与 与糖尿病、炎症性肠病、多发性硬化症、哮喘等疾病相关的功能 动脉粥样硬化、特应性皮炎、登革热、艾滋病毒、巨细胞病毒、结核病、埃博拉病毒和免疫肿瘤学。 每位导师均在免疫学或免疫疾病领域获得国际认可，并且每位导师均在免疫学或免疫疾病领域获得国际认可。 拥有丰富的同行评审研究经验和跟踪记录。该计划将向博士、医学博士、 对免疫系统基础和应用研究感兴趣的医学博士/博士科学家。培训计划 将包括 12 至 24 个月的实验室研究经验，并由专家密切监督 一位或多位致力于免疫治疗相关问题的导师。该研究的研究背景 教师导师多种多样，但共同的主题都集中在原代细胞的生物学上 免疫系统，包括T细胞、B细胞、NKT细胞、巨噬细胞、树突状细胞、中性粒细胞等。 然后，培训计划将代表一种跨学科方法，每个学员都会接触到切割 前沿和最先进的免疫学技术和系统，用于基础和转化 免疫系统的发现。我们当前和过去的学员都有出色的研究记录 成就。全国范围内招募新学员，努力招好、留住 特殊少数族裔、妇女和弱势候选人。受训者将根据他们之前的经历进行选择 学术表现、研究经验、出版物、访谈和导师的推荐。 学员将参加机构研讨会、期刊俱乐部、课程和免疫学会议 旨在扩大他们对免疫学和免疫疾病的理解的广度。所有练习生 将接受负责任的研究行为和科学诚信原则的指导。的目标 该计划旨在促进全面发展的免疫学家的发展，他们可以填补急需的学术职位 职位，谁可以竞争并成功获得独立研究资助，谁可以 为旨在治疗免疫相关疾病的生物技术和制药方法做出贡献。

项目成果

Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells.

• DOI: 10.3390/ijms23179875
• 发表时间: 2022-08-30
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Saigusa, Ryosuke;Vallejo, Jenifer;Gulati, Rishab;Suthahar, Sujit Silas Armstrong;Suryawanshi, Vasantika;Alimadadi, Ahmad;Makings, Jeffrey;Durant, Christopher P.;Freuchet, Antoine;Roy, Payel;Ghosheh, Yanal;Pandori, William;Pattarabanjird, Tanyaporn;Drago, Fabrizio;Taylor, Angela;McNamara, Coleen A.;Shemesh, Avishai;Lanier, Lewis L.;Hedrick, Catherine C.;Ley, Klaus
• 通讯作者: Ley, Klaus

Unaltered T cell responses to common antigens in individuals with Parkinson's disease.

• DOI: 10.1016/j.jns.2022.120510
• 发表时间: 2023-01-15
• 期刊: JOURNAL OF THE NEUROLOGICAL SCIENCES
• 影响因子: 4.4
• 作者: Williams, Gregory P.;Muskat, Kaylin;Frazier, April;Xu, Yaqian;Mateus, Jose;Grifoni, Alba;Antunes, Ricardo da Silva;Weiskopf, Daniela;Amara, Amy W.;Standaert, David G.;Goldman, Jennifer G.;Litvan, Irene;Alcalay, Roy N.;Sulzer, David;Arlehamn, Cecilia S. Lindestam;Sette, Alessandro
• 通讯作者: Sette, Alessandro

Divergent metabolic programmes control two populations of MAIT cells that protect the lung.

• DOI: 10.1038/s41556-023-01152-6
• 发表时间: 2023-06
• 期刊: Nature cell biology
• 影响因子: 21.3

Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.

• DOI: 10.3233/jpd-223241
• 发表时间: 2022
• 期刊: Journal of Parkinson's disease
• 作者: Williams GP;Schonhoff AM;Sette A;Lindestam Arlehamn CS
• 通讯作者: Lindestam Arlehamn CS

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

• DOI: 10.1038/s41467-018-03493-5
• 发表时间: 2018-03-15
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Gaddis DE;Padgett LE;Wu R;McSkimming C;Romines V;Taylor AM;McNamara CA;Kronenberg M;Crotty S;Thomas MJ;Sorci-Thomas MG;Hedrick CC
• 通讯作者: Hedrick CC