Well-being as a Protective Factor against Cognitive Decline and Dementia Risk

幸福感是预防认知能力下降和痴呆风险的保护因素

• 批准号: 10675592
• 负责人: Emily C Willroth
• 金额: $ 24.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675592
• 关键词: Address; Adult; Aging; Agreement; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-Protein; Area; Autopsy; Award; Blood Vessels; Brain Pathology; Buffers; Cognitive; Collaborations; Data; Data Analyses; Data Collection; Dementia; Diagnosis; Disease; Education; Elderly; Environment; Epidemiologist; Etiology; Health; Health behavior; Impaired cognition; Individual; Intervention; Knowledge; Lewy Bodies; Lewy Body Disease; Life; Link; Longevity; Longitudinal Studies; Measures; Medical; Memory; Mentors; Mentorship; Modeling; Neurobehavioral Manifestations; Neurofibrillary Tangles; Pathology; Pathway interactions; Personal Satisfaction; Personality; Physiological Processes; Predictive Factor; Psychologist; Public Health; Research; Residual state; Risk Factors; Sampling; Scientist; Severities; Social Sciences; Stress; Symptoms; Techniques; Testing; Training; Well in self; Work; career; causal model; cognitive function; comorbidity; data analysis pipeline; dementia risk; demographics; design; end of life; experience; hedonic; hippocampal sclerosis; improved; longitudinal dataset; medical schools; negative affect; neuropathology; physical conditioning; prospective; protective factors; protein TDP-43; psychosocial; religious order study; resilience; satisfaction; skills; tau Proteins; tau aggregation; trait

PROJECT SUMMARY The Pathway to Independence Award will equip the candidate with the knowledge and skills to study well-being as a key protective factor against Alzheimer’s Disease and Related Dementias (ADRD). ADRD is a substantial and rapidly-growing public health burden, with no available disease-modifying treatments. However, not everyone with ADRD-related neuropathology experiences symptoms of dementia. Well-being is an understudied but important predictor of cognitive resilience to ADRD neuropathology, given that it has been associated with ADRD risk and is amenable to intervention. The candidate will evaluate multiple well-being predictors of resilience to ADRD pathology (Aim 1). To address questions related to direction of causality, the candidate will examine bidirectional associations between well-being and cognitive decline in older adults with and without ADRD (Aim 2). To increase the generalizability and replicability of findings, both research aims will be conducted in multiple existing longitudinal datasets. To support the candidate in conducting the proposed research, training in three areas is planned: (a) Alzheimer’s Disease and Related Dementias (ADRD), (b) causal modeling of longitudinal observational data, and (c) Integrative Data Analysis. Training will occur under the mentorship of renowned experts in each field (including two personality and health psychologists, an epidemiologist, and a quantitative psychologist). During the K99 period, the candidate will receive training in ADRD that will be applied to both aims of the proposed research and training in causal modeling techniques that will be used in the second aim of the proposed research. During both periods of the award, the candidate will work with the mentor team to build relationships with existing longitudinal studies and develop an Integrative Data Analysis pipeline. The training environment at the Department of Medical Social Sciences, Northwestern Feinberg School of Medicine will be ideal for the proposed training and research, as well as for developing the candidate’s professional skills. Together, the award will help the candidate launch her research career as an independent scientist with unique expertise in well-being, cognitive and physical health across the lifespan, and longitudinal modeling.

项目摘要 获得独立奖的途径将使候选人掌握学习的知识和技能 幸福感是针对阿尔茨海默氏病和相关痴呆症（ADRD）的关键保护因素。 Adrd是一个 大量且快速增长的公共卫生伯恩伯恩（Burnen），没有可用的疾病改良治疗。 但是，并非每个患有ADRD相关的神经病理学经历痴呆症症状的人。幸福是 鉴于它已经是一种理解但重要的预测指标 与ADRD风险相关，并且可以接受干预。候选人将评估多个幸福感 预测对ADRD病理学的韧性（AIM 1）。要解决与偶然性方向相关的问题， 候选人将检查老年人的幸福感与认知能力下降之间的双向关联 并且没有ADRD（AIM 2）。为了提高发现的普遍性和可复制性，这两个研究目的都将 在多个现有的纵向数据集中进行。支持候选人进行拟议的 计划在三个领域进行培训：（a）阿尔茨海默氏病和相关痴呆症（ADRD），（b） 纵向观察数据的因果建模和（c）综合数据分析。培训将在 每个领域著名专家的心态（包括两个人格和健康心理学家，一个 流行病学家和定量心理学家）。在K99期间，候选人将接受培训 ADRD将应用于因果建模技术的拟议研究和培训的目标 这将用于拟议研究的第二个目标。在两个奖项期间，候选人 将与心理团队合作，与现有的纵向研究建立关系，并开发 集成数据分析管道。医学社会科学系的培训环境， 西北费恩伯格医学院将是拟议的培训和研究的理想选择，以及 发展候选人的专业技能。该奖项将帮助候选人启动她的研究 作为独立科学家的职业，在整个福祉，认知和身体健康方面拥有独特的专家 寿命和纵向建模。