Administrative Core

行政核心

• 批准号: 10673107
• 负责人: Markus Müschen
• 金额: $ 9.47万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10673107
• 关键词: Adherence; Area; Biological; Budgets; Communication; Data Analyses; Ensure; Experimental Designs; Funding; Goals; Grant; Human; Institution; Laboratories; Lead; Leadership; Modeling; Performance; Peripheral; Preparation; Program Research Project Grants; Regulation; Reproducibility; Research; Research Personnel; Resources; Sample Size; Schedule; Specimen; T-Cell Lymphoma; United States National Institutes of Health; Vertebrates; design; experimental analysis; meetings; member; programs

SUMMARY The central purpose of a P01 Program is to support integrated research involving independent investigators who share research capabilities and resources toward a common goal. Essential to this effort is scientific rigor and reproducibility in all aspects of the research effort. To accomplish this, the Administrative Core will oversee the performance of all aspects of the proposal and provide statistical support to ensure the appropriate design and analysis of experiments. The Core proposes the following Specific Aims: Specific Aim 1: Manage all program-related administrative activities. Core A will be responsible for management of the budget, preparation of non-competing renewals, communication with the NIH, fiscal oversight, disbursement of funds, and general scientific oversight of the Projects and Cores. Specific Aim 2: Provide statistical support for the experimental efforts conducted through the Projects. Core A will be responsible for ensuring statistically-rigorous and transparent research in all areas supported by the P01. This will include statistically-appropriate experimental design, including power and sample size calculations, and modeling and data analysis that considers relevant biological variables. Additionally, Core A will focus on adherence to reproducibility standards in all grant-related activities. Specific Aim 3: Maintain compliance with appropriate regulations. Core A will ensure that all Projects and Cores comply with regulations governing experimentation with vertebrate animals, biosafety, deidentified human specimens and other relevant federal, state, local, and institutional regulations. Specific Aim 4: Coordinate, schedule, and lead all scientific meetings. Core A will coordinate scientific meetings to maximize interactions between Projects, provide critical input into ongoing research efforts, and ensure effective utilization of Cores. Core A will organize and lead monthly meetings of the P01 leadership and members of their respective laboratories, and will coordinate annual meetings with the Scientific Advisory Board.

概括 P01 计划的中心目的是支持独立研究人员参与的综合研究，这些研究人员 为实现共同目标而共享研究能力和资源。这项工作的关键是科学严谨 研究工作各个方面的可重复性。为了实现这一目标，行政核心将监督 提案各方面的绩效并提供统计支持，以确保适当的设计和 实验分析。核心提出以下具体目标： 具体目标 1：管理所有与计划相关的行政活动。 核心 A 将负责管理预算、准备非竞争性续约、 与 NIH 的沟通、财政监督、资金支付以及对研究的一般科学监督 项目和核心。 具体目标 2：为通过项目进行的实验工作提供统计支持。 核心A将负责确保在所有支持的领域进行严格的统计和透明的研究 P01。这将包括统计上适当的实验设计，包括功效和样本量 考虑相关生物变量的计算、建模和数据分析。此外，核心A 将重点关注在所有赠款相关活动中遵守可重复性标准。 具体目标 3：保持遵守适当的法规。 核心 A 将确保所有项目和核心均符合脊椎动物实验管理法规 动物、生物安全、身份不明的人类标本和其他相关联邦、州、地方和机构 法规。 具体目标 4：协调、安排和领导所有科学会议。 核心 A 将协调科学会议，以最大限度地提高项目之间的互动，为 持续的研究工作，并确保核心的有效利用。核心 A 将每月组织和领导 P01领导层和各自实验室的成员举行会议，并将协调年度 与科学顾问委员会举行会议。