VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)

衰老成人大脑连接体 (AABC) 的脆弱性和弹性

• 批准号: 10673890
• 负责人: Beau M Ances
• 金额: $ 674.02万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673890
• 关键词: Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Behavior; Biological; Biological Markers; Blood; Blood Pressure; Brain; Centenarian; Clinical; Cognition; Cognitive; Communities; Conceptions; Data; Data Analyses; Databases; Dementia; Development; Diet; Dimensions; Disease; Early identification; Elderly; Enrollment; Ensure; Foundations; Funding; General Population; Genetic; Goals; Health; Human; Human Resources; Image; Image Analysis; Impaired cognition; Impairment; Individual; Inflammation; Informatics; Infrastructure; Leadership; Life; Life Style; Light; Longevity; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Menopause; Mission; Multimodal Imaging; Multiomic Data; Neurocognitive; Participant; Pathology; Pattern; Perimenopause; Phase Transition; Phenotype; Physical activity; Physiological; Plasma; Population; Postmenopause; Protocols documentation; Quality Control; Race; Request for Applications; Research Personnel; Resistance; Resolution; Resources; Risk; Risk Factors; Running; Sampling; Site; Specimen; Standardization; Statistical Models; Stress; Structure; Symptoms; Time; Underrepresented Populations; United States National Institutes of Health; Woman; aged; allostatic load; cognitive change; cognitive testing; cohort; connectome; data acquisition; data integration; data sharing; data sharing networks; follow-up; genetic information; multiple omics; neural; neurochemistry; neurofilament; neuroimaging; neuroinflammation; novel; phenotypic data; physical inactivity; pre-clinical; preservation; psychologic; recruit; resilience; resilience factor; response; sex; sleep quality; social; statistics; tau-1; vasomotor symptoms

ABSTRACT FOR OVERVIEW The Aging Adult Brain Connectome (AABC) leverages the existing infrastructure developed by the Human Connectome Project for Aging (HCP-A) by obtaining longitudinal follow-up data (neuroimaging, cognitive testing, and blood) using a standardized protocol from a well characterized cohort of over 1,000 healthy individuals to generate within-participant brain trajectories for up to 10 years. At initial recruitment, individuals enrolled in the HCP-A were generally physically and cognitively healthy but over time some will develop preclinical AD or early cognitive changes due to AD or ADRD. The AABC is comprised of four Projects: Project 1 examine the effects of stress and allostatic load, including inflammation, during the early adult period. Project 2 examines the effects of lifestyle behaviors on the trajectory of cognitive and brain changes during the mid adult period. Project 3 examine the effects of menopause transition/vasomotor symptoms during the mid adult period. Project 4 exam- ine the clinical and neural indicators of resiliency and resistance to AD and ADRD in the later decades of adult- hood. The AABC also consists of 4 Cores: The Administration Core (AC) will provide essential core and site leadership to carry out the scientific mission of the AABC. The diversity recruitment and retention unit (DRRU) will be located within this core and will ensure that the AABC continues to recruit and retain an adequate distri- bution of races that is currently seen in the US. The Integrated Data Acquisition Core (IDAC) provides expertise and personnel from each site to acquire high quality neuroimaging, deep phenotyping of non-imaging data, and biosamples from each site.The Informatics, Data Analysis, and Statistics Core (IDASC) will house project imag- ing data using the IntraDB database, will perform quality control of raw and analyzed data, will develop and run cross-sectional and longitudinal pipelines to produce multi-modal imaging data phenotypes for each project, will provide dimension-reduced summaries, will impute missing data; and will develop and run statistical models for each project. The IDASC will also be responsible for data sharing with the general public. The Genetics and Multi-omics Specimens Core (GMSC) will provide genetic information on participants evaluated through the AABC who have been characterized using a uniform protocol. Multi-omic data and AD biomarker data will be generated by the GMSC.

摘要摘要 老化的成人脑连接组（AABC）利用了人类开发的现有基础设施 通过获得纵向随访数据（神经成像，认知测试， 血液）使用来自超过1,000个健康个体的良好表征的标准化方案 产生参与性的大脑轨迹长达10年。在最初招募时，参加了 HCP-A通常在身体和认知上健康，但随着时间的流逝，有些会发展临床前广告或早期 由于AD或ADRD引起的认知变化。 AABC由四个项目组成：项目1检查效果 在成年初期，压力和同性载荷（包括炎症）。项目2检查效果 成年时期认知和大脑变化轨迹的生活方式行为。项目3 检查成人中期更年期过渡/血管舒张症症状的影响。项目4考试 - 在后来几十年 兜帽。 AABC还包括4个核心：管理核心（AC）将提供必需的核心和现场 领导执行AABC的科学任务。多样性招聘和保留单位（DRRU） 将位于该核心内，并确保AABC继续招募并保留足够的分散 目前在美国看到的种族。集成数据采集核心（IDAC）提供专业知识 和每个站点的人员都能获得高质量的神经影像学，非成像数据的深层表型和 每个站点的生物样本。信息学，数据分析和统计核心（IDASC）将容纳项目的想象 使用IntradB数据库的数据将对原始数据和分析数据进行质量控制，将开发和运行 横截面和纵向管道，为每个项目产生多模式成像数据表型，将 提供降低维度的摘要，将归为丢失的数据；并将开发和运行统计模型 每个项目。 IDASC还将负责与公众的数据共享。遗传学和 多词标本核心（GMSC）将提供有关通过该参与者评估的参与者的遗传信息 使用统一协议进行表征的AABC。多矩数据和AD生物标志物数据将是 由GMSC生成。