2016 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Gordon-Kenan Research Seminar

2016年纤溶酶原激活与细胞外蛋白水解戈登研究会议暨戈登-凯南研究研讨会

基本信息

批准号：
8983504
负责人：
Lindsey A Miles
金额：
$ 3.1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8983504
关键词：
Achievement Aging Alteplase Alzheimer&apos s Disease Area Basic Science Biology Blood Vessels Cardiovascular Physiology Cardiovascular system Cell physiology Clinical Research Colitis Collaborations Communicable Diseases Deep Vein Thrombosis Development Discipline Disease Environment Functional disorder Funding Funding Applicant Goals Hematopoiesis Homeostasis International Lead Location Malignant Neoplasms Mediating Mediator of activation protein Metabolism Muscular Dystrophies Myocardial Infarction Natural regeneration Nervous System Physiology Neuraxis Obesity Participant Pathologic Processes Peptide Hydrolases Physiological Processes Plasminogen Postdoctoral Fellow Process Proteolysis Pulmonary Emphysema Research Research Personnel Role Scientist Stroke System Tissues Translating Translations Traumatic Brain Injury Tumor Biology Underrepresented Minority Woman Women&apos s Health angiogenesis experience extracellular frontier graduate student human disease inhibitor/antagonist innovation insight interdisciplinary approach meetings nervous system disorder new technology novel novel therapeutic intervention peer peer networks posters public health relevance receptor senescence stem cell biology symposium

项目摘要

DESCRIPTION (provided by applicant): Funds are sought for partial support of the 2016 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference (GRC) and Gordon Research Seminar (GRS). These are paired conferences held sequentially at the same location, February 13-14, 2016 for the GRS, and February 14-19 for the GRC. The GRC has been held continuously every two years since 1990 and enjoys an outstanding international reputation. It brings together a group of highly motivated participants with diverse scientific backgrounds that engage in intensive, yet informal, discussions at the frontier of research related to the plasminogen activation system and associated extracellular proteases in an "off-the-record" fashion. The conference thus provides a unique opportunity for the leading researchers in the world from a broad range of disciplines to present their latest unpublished research related to plasminogen activation and extracellular proteolysis, and to discuss innovative ways to translate their research into new therapies. Previous research in our field has led to the development of tissue plasminogen activator (tPA) for the successful treatment of a wide range of thromboembolic disorders, and the discovery of important roles for the plasminogen activation system and extracellular proteolysis in a number of physiologic and pathologic processes. In the 2016 meeting, emphasis will be placed on Women's Health and The Role of Extracellular Proteolysis in Senescence and Aging. Breakthrough findings in plasminogen activation and extracellular proteolysis in vascular biology, central nervous system function and dysfunction, traumatic brain injury, Alzheimer's disease, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, cardiovascular function, and angiogenesis will be discussed. New technological advances in the field of proteases will be presented. Since translating basic research into treatments is a major focus of the 2016 meeting, the cutting- edge in new therapies in our field will be discussed. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of researchers, and a strong emphasis has been made on the inclusion of women and underrepresented minorities as Discussion Leaders and Speakers, and will continue on Poster Presenters, and Attendees. The associated GRS is a novel feature that will provide a unique opportunity for young scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chair, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.

描述（由申请人提供）：寻求资金为 2016 年纤溶酶原激活和细胞外蛋白水解戈登研究会议 (GRC) 和戈登研究研讨会 (GRS) 提供部分支持。这些会议是 2 月 13 日至 14 日在同一地点依次举行的配对会议。，GRS于2016年举行，GRC于2月14日至19日举行，此后每两年连续举办一次。它成立于 1990 年，享有卓越的国际声誉，汇集了一群具有不同科学背景、积极性高的参与者，他们在“非-非-”领域中，在与纤溶酶原激活系统和相关细胞外蛋白酶相关的研究前沿进行了深入而非正式的讨论。因此，会议为世界各个学科的领先研究人员提供了一个独特的机会，展示他们与纤溶酶原激活和细胞外蛋白水解相关的最新未发表的研究，并讨论创新方法将他们的研究转化为新疗法。我们领域的先前研究导致了组织纤溶酶原激活剂（tPA）的开发，成功治疗了多种血栓栓塞性疾病，并发现了纤溶酶原激活系统和细胞外的重要作用。蛋白质水解在许多生理和病理过程中的作用 2016 年会议的重点将放在女性健康和细胞外蛋白质水解在衰老和衰老中的作用。将讨论血管生物学中的纤溶酶原激活和细胞外蛋白水解、中枢神经系统功能和功能障碍、创伤性脑损伤、阿尔茨海默病、组织稳态和再生、造血、干细胞生物学、代谢和肥胖、肿瘤生物学、心血管功能和血管生成。由于将基础研究转化为治疗方法是 2016 年会议的主要焦点，因此我们将介绍该领域的前沿新疗法。与会者将通过邀请和在线提交的申请来选择，他们将被选为代表不同领域的研究人员，并且重点强调将女性和代表性不足的少数群体纳入讨论领袖和演讲者，并将继续进行。相关的 GRS 是一个新颖的功能，将为年轻科学家提供分享 GRC 经验的独特机会。这个为期两天的研讨会将由研究生和博士后研究员在领先研究人员的支持下组织。和GRC 主席，将使纤溶酶原激活和细胞外蛋白水解领域的初级研究人员聚集在一起讨论他们当前的研究，同时与同行建立非正式网络，这可能会带来终生的合作和科学成就。