Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle

ACT 队列中的体力活动、久坐行为和睡眠：24 小时活动周期

• 批准号: 10672368
• 负责人: Dori E Rosenberg
• 金额: $ 64.71万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672368
• 关键词: Accelerometer; Activities of Daily Living; Activity Cycles; Adult; Age-associated memory impairment; Aging; Alzheimer' s Disease; Beds; Behavior; Behavioral; Brain; Cardiovascular Diseases; Circadian Rhythms; Clinical; Cognition; Cognitive; Collaborations; Collection; Complement; Complex; Data; Data Collection; Dementia; Development; Devices; Education; Elderly; Energy Metabolism; Equilibrium; Future; Gait speed; Goals; Guidelines; Hand Strength; Health; Heterogeneity; Hour; Image; Impaired cognition; Income; Individual; Information Systems; Intervention; Joints; Life; Life Cycle Stages; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Metabolic syndrome; Modeling; Monitor; Mood Disorders; Outcome; Participant; Patient Outcomes Assessments; Patient Self-Report; Pattern; Phase; Physical Function; Physical activity; Physical assessment; Population; Research; Resources; Risk; Risk Reduction; Sleep; Sleep disturbances; Testing; Thigh structure; Time; Work; Wrist; actigraphy; adverse childhood events; age related; cognitive ability; cognitive function; cohort; comorbidity; data resource; diaries; executive function; functional independence; healthy aging; immune function; improved; innovation; instrument; neuroimaging; neuropathology; novel; physical conditioning; programs; response; screening; sedentary lifestyle; sex; sleep behavior; sleep quality; theories; verbal; vigorous intensity

Physical activity (PA), sedentary behavior (SB), and sleep all impact cognitive and physical health in aging. Most research to date has focused on how time spent in each of these behaviors individually impacts health outcomes. However, interactions of PA, SB, and sleep likely account in part for the tremendous heterogeneity in aging-related health outcomes, and their optimal balance across the 24-hour day in supporting healthy aging is not known. This proposal capitalizes upon unique resources available through the Adult Changes in Thought (ACT) U19 Program to explore the inter-relatedness of PA, SB, sleep, and longitudinal trajectories of cognitive and physical health. The 24-hour activity cycle paradigm as a model for determining longitudinal inter- relatedness of PA, SB, and sleep on health outcomes is innovative, as is our proposed collection of device- based data to complement self-reported outcomes. This project proposes to use a number of innovative statistical approaches to analyze the complex relationships between the 24-hour activity cycle and trajectories of cognition and physical functioning. Scientific rigor is supported by objective monitoring of 24-hour behaviors and builds upon more than two decades of ACT data in a well-characterized clinical population. Measures of cognitive and physical function will include Cognitive Abilities Screening Instrument item response theory scores, specialized tests of executive functioning and verbal fluency, self-reported activities of daily living, gait speed, rising from a chair, and grip strength. For Aim 1, we will test bidirectional associations relating cognitive and physical function to the 24-hour activity cycle using device-assessed measures of PA and SB, and self- reported sleep. We hypothesize that (a) historically better cognitive and physical function will be independently associated with higher levels of PA, lower SB, and better sleep in ACT participants, and (b) more PA, less SB, and better sleep will be independently associated with better future maintenance of cognitive and physical function. For Aim 2, we hypothesize that (a) historically better cognitive and physical function will be independently associated with better device-assessed sleep quality and circadian rhythms in ACT participants, and (b) better device-assessed sleep quality and circadian rhythms will be independently associated with better future maintenance of cognitive and physical function. For both Aims, we will construct combined 24- hour activity cycle profiles (based on different balances of PA, SB, and sleep) and explore how profiles are associated with historical trajectories of and future changes in cognitive and physical function. Collaboration with other Cores will provide new data about how Life Course and Clinical Core variables influence associations, as well as new information about relationships between the 24-hour activity cycle and novel neuroimaging data. Ultimately, our results will provide much needed evidence to inform the development of guidelines and interventions to promote healthy aging in older adults, potentially including reducing risk for cognitive decline and late life dementia including Alzheimer’s disease.

体育活动（PA），久坐行为（SB）和睡眠都会影响衰老的认知和身体健康。 迄今为止，大多数研究都集中在每种行为中花费的时间如何分别影响健康 结果。但是，PA，SB和睡眠的相互作用可能部分地说明了巨大的异质性 在与衰老相关的健康成果中，以及在24小时内的最佳平衡，以支持健康的衰老 不知道。该提案资本利用通过成人思想变化获得的独特资源 （ACT）U19程序探讨PA，SB，睡​​眠和认知纵向轨迹的相关性 和身体健康。 24小时活性循环范式作为确定纵向间间的模型 PA，SB和睡眠与健康结果的相关性是创新的，我们建议的设备收藏也是如此 - 基于自我报告的结果的基于数据。这个项目提出了使用许多创新的建议 分析24小时活动周期和轨迹之间复杂关系的统计方法 认知和身体功能。科学严谨受到对24小时行为的客观监控的支持 并建立在二十多年的ACT数据基础上，在特征良好的临床人群中。措施 认知和身体功能将包括认知能力筛选仪器项目响应理论 分数，执行功能和口头流利度的专业测试，日常生活的自我报告的活动，步态 速度，从椅子上升起，并抓住力量。对于AIM 1，我们将测试与认知有关的双向关联 使用PA和SB的设备评估的度量以及自我的24小时活动周期的身体功能以及自我 报告睡眠。我们假设（a）历史上更好的认知和身体机能将是独立的 与较高水平的PA，较低的SB和ACT参与者更好的睡眠相关，（B）PA，更少的SB，SB， 更好的睡眠将与认知和身体的更好的未来维护独立联系 功能。对于AIM 2，我们假设（a）历史上更好的认知和身体机能将是 与ACT参与者的循环睡眠质量和昼夜节律相关联，独立于 （b）更好地评估设备的睡眠质量和昼夜节律将与 更好地维持认知和身体机能。对于这两个目标，我们将构建合并的24- 小时活动周期轮廓（基于PA，SB和睡眠的不同余额）并探讨轮廓的方式 与认知和身体机能的历史轨迹和未来变化有关。合作 与其他核心一起，将提供有关生命课程和临床核心变量如何影响的新数据 关联以及有关24小时活动周期与新颖的关系的新信息 神经影像数据。最终，我们的结果将提供急需的证据，以告知开发 指南和干预措施以促进老年人健康衰老，可能包括降低风险 认知能力下降和晚期痴呆在内，包括阿尔茨海默氏病。