Core C Molecular Informatics Core

核心 C 分子信息学核心

• 批准号: 10670897
• 负责人: JOHN W CRABB
• 金额: $ 29.65万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670897
• 关键词: Acceleration; Animal Model; Area; Bioinformatics; Cells; Center Core Grants; Clinic; Collaborations; Complex; Consultations; Data; Data Analyses; Development; Disease; Doctor of Philosophy; Experimental Designs; Eye; Eye diseases; Faculty; Fostering; Funding; Genomics; Goals; Grant; Human; Informatics; Molecular; Ocular Pathology; Pathway interactions; Post-Translational Protein Processing; Proteins; Proteomics; Qualifying; Research; Research Personnel; Research Support; Resources; Scientist; Services; System; Talents; Technology; Time; Tissues; Training; Vision; Vision research; Visual System; experience; insight; instrumentation; metabolomics; metabolomics resource; novel therapeutics; programs; protein protein interaction; recruit; research faculty; skills; vision science

Abstract Molecular Informatics Core The Molecular Informatics Module will provide assistance with proteomic and metabolomic/isotopomic research strategies and technologies to the investigators involved in this P30 Cole Eye Vision Research Core. The time required to develop expertise in proteomic and metabolomic technologies often generates research roadblocks to capable investigators with other specialized skills. Specifically, the module will provide 1) experimental design consultation, technical support, and data analysis for global and targeted protein quantitation in normal and diseased ocular tissues and cell systems, including proteomic bioinformatics; 2) a centralized resource for proteomic research strategy and technical support for vision science studies involving protein identification, protein-protein interactions and posttranslational modifications; 3) experimental design consultation and technical support for metabolomic profiling in normal and diseased ocular tissues and cell systems; and 4) a centralized resource for metabolomic research strategy and technical support for vision science studies, including metabolomic bioinformatics. This core module will support NEI R01-funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1-funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

抽象的 分子信息学核心 分子信息学模块将为蛋白质组学和代谢组/同位素研究策略提供帮助 以及参与P30 Cole Eye Vision Research Core的研究人员的技术。发展所需的时间 蛋白质组学和代谢组学技术方面的专业知识通常会为有能力的研究人员带来研究障碍 其他专业技能。具体而言，该模块将提供1）实验设计咨询，技术支持以及 在正常和患病的眼组织和细胞系统中的全球和靶向蛋白质定量的数据分析，包括 蛋白质组学生物信息学； 2）蛋白质组学研究策略的集中资源和对视觉科学的技术支持 涉及蛋白质鉴定，蛋白质 - 蛋白质相互作用和翻译后修饰的研究； 3）实验 在正常和患病的眼组织和细胞系统中为代谢组分析的设计咨询和技术支持； 4）用于代谢组学研究策略和视觉科学研究的技术支持的集中资源，包括 代谢组生物信息学。该核心模块将支持NEI ​​R01资助的调查人员，帮助新招募 调查人员获得NEI R01赠款提交的数据，促进了由RO1资助的调查人员之间的协作互动 以及新招募的调查人员，吸引来自其他部门的调查员来研究视觉系统，并成为一个 随着我们扩大研究学院的发展，有价值的部门资源在吸引更多的愿景科学家加入我们的计划中。