Assessing Telephone All Nations Breath of Life for Efficacy

评估电话万国生命之息的功效

基本信息

批准号：
10668295
负责人：
CHRISTINE Makosky DALEY
金额：
$ 64.73万
依托单位：
LEHIGH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10668295
关键词：
Abstinence Address African American population American Indians Anthropology Bayesian Modeling Behavioral Biochemical Biometry Cancer Etiology Cardiovascular Diseases Cause of Death Cessation of life Communities Community Participation Cotinine County Demographic Factors Education Electronic cigarette Epidemiology Ethnic Population Failure Family Practice Feasibility Studies Geographic Locations Goals Health Individual Intervention Kansas Letters Life Malignant neoplasm of lung Medical center Methods Motivation Nicotine Outcome Persons Pharmacotherapy Plants Population Premature Mortality Prevalence Qualifying Recording of previous events Recreation Reporting Research Research Methodology Research Personnel Risk Factors Salivary Self Efficacy Smoker Smoking Social support Telephone Testing Tobacco Tobacco use United States Universities acceptability and feasibility addiction cigarette smoking community based participatory research community college community organizations efficacy testing efficacy trial enhancing factor ethnic identity follow-up future implementation health disparity health literacy implementation study intervention program pilot test primary endpoint programs psychosocial quitline recruit reservation-based response retention rate smoking cessation success telephone based tobacco control urban Native American

项目摘要

PROJECT SUMMARY AI have the highest smoking rates of all major ethnic groups in the US, at 31.8%, nearly double that of both African Americans and Whites. Despite these high rates of smoking, few researchers have addressed this issue, in part because tobacco is a sacred plant to many AI and cannot be treated completely negatively, as most smoking cessation programs do. Researchers at the University of Kansas Medical Center (KUMC) and Johnson County Community College (JCCC) have been working with regional partners using community- based participatory research (CBPR) to address recreational tobacco since 2003. We have developed a successful culturally tailored program, All Nations Breath of Life (ANBL), that respects tobacco as a sacred plant and promotes honoring it rather than abusing it recreationally. Our in-person, group-based program had an intent-to-treat quit rate of 27.9% versus 17.4% compared to current best practices at end of treatment (12 weeks) in a reservation-based efficacy trial (N=463). Cessation was 20% vs. 12% at 6 months (p=0.02). In a large urban implementation feasibility study (N=312 across five states), the quit rate was 22% at 6-months (p<0.002 compared to the highest previously reported rates for an urban AI population); retention was 71%. Based on a request from the community, we created an individual telephone-based version of the program, tANBL, which was pilot tested with N=33 individuals and had a 24.2% quit rate at 6 months, assuming those lost to follow-up as smokers. The program had an 81.8% retention rate at 6 months. We are now ready to formally test tANBL for efficacy; that is proposed here using a Bayesian Adaptive Design (BAD) and our community-based participatory research (CBPR) framework. We will address the following specific aims: (1) To compare tANBL with an individual non-tailored telephone-based comparison program (CP) using a Bayesian Adaptive Design (n=500); (2) To examine the acceptability and feasibility of implementing an individual telephone-based ANB and (3) To compare individual telephone ANBL with an individual non-tailored telephone-based comparison program using a Bayesian Adaptive Design (N=500). Our primary endpoint will be 7-day point prevalence abstinence from recreational smoking biochemically verified by salivary cotinine level at 6 months post-baseline. Quit rates in the ANBL program will be significantly better than in the non- tailored program (24% versus 10%). We will address the following secondary aims: (1) To compare tANBL and CP 30-day point prevalence and continuous abstinence rates at 6 months and 12 months post-baseline; (2) To examine individual factors such as type of pharmacotherapy (if any), level of addiction, use of other nicotine products such as e-cigarettes, quitting history, motivation, tobacco health literacy, social support, self- efficacy, ethnic identity, psychosocial health and demographic factors for effect on quit rates; (3) To maximize and assess the cultural relevance of the intervention program and all of its components and (4) To identify factors that enhance dissemination of telephone-based ANBL and contribute to program success or failure.

项目摘要 AI在美国所有主要种族中的吸烟率最高，为31.8％，几乎两倍非裔美国人和白人。尽管吸烟率很高，但很少有研究人员解决这个问题问题，部分原因是烟草是许多人AI的神圣植物，不能完全对待，因为大多数戒烟计划都这样做。堪萨斯大学医学中心（KUMC）的研究人员和约翰逊县社区学院（JCCC）一直使用社区与区域合作伙伴合作 - 自2003年以来，基于参与性研究（CBPR）以解决娱乐性烟草。我们已经开发了一个成功量身定制的计划，所有国家生活的呼吸（ANBL），尊重烟草是神圣的植物并促进纪念它，而不是虐待它。我们面对面的，基于小组的计划有与治疗结束时目前的最佳实践相比几周）在基于预订的功效试验中（n = 463）。停止在6个月时为20％比12％（p = 0.02）。在大型城市实施可行性研究（五个州的n = 312），戒烟率为22％在6个月时（p <0.002与以前报告的城市人工智能人口的比率最高相比）；保留率为71％。根据社区的要求，我们创建了一个基于电话的单个程序版本， tanbl，通过n = 33个人进行了试点测试，并在6个月时以24.2％的戒烟率进行了测试作为吸烟者迷失了随访。该计划在6个月时保留率为81.8％。我们现在准备好了正式测试tanbl的功效；这是在这里使用贝叶斯自适应设计（不良）和我们的基于社区的参与性研究（CBPR）框架。我们将解决以下具体目标：（1）将Tanbl与单独的非限制电话的比较程序（CP）进行比较贝叶斯自适应设计（n = 500）; （2）检查实施的可接受性和可行性基于电话的单个ANB和（3）将单个电话ANBL与单个未限制的人进行比较使用贝叶斯自适应设计（n = 500）的基于电话的比较程序。我们的主要终点将是7天的娱乐性吸烟生物化学验证的7天的患病率。在基线后6个月的水平。 ANBL计划中的戒烟率将比非非 - 量身定制的计划（24％对10％）。我们将解决以下次要目标：（1）比较tanbl 在基线后6个月零12个月时，CP 30天的患病率和连续的节制率；（2）检查单个因素，例如药物治疗类型（如果有），成瘾水平，使用其他因素电子烟等尼古丁产品，退出历史，动机，烟草健康素养，社会支持，自我疗效，种族认同，社会心理健康和人口统计学因素，以影响戒烟率；（3）最大化并评估干预计划及其所有组成部分的文化相关性，以及（4）确定增强基于电话的ANBL传播并导致计划成功或失败的因素。