Hormonal regulation of sensory processing during parental care

父母照顾期间感觉处理的激素调节

• 批准号: 10667468
• 负责人: Kristina O. Smiley
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10667468
• 关键词: Affect; Afferent Neurons; Animal Model; Animals; Auditory; BRAIN initiative; Behavior; Behavioral; Brain; Brain region; Caring; Child; Child Health; Child Rearing; Complex; Crying; Cues; Detection; Development; Electrophysiology (science); Emotional; Etiology; Exposure to; Fixed Action Patterns; Goals; Growth; Hearing; Hearing Tests; Hormonal; Hormones; Impairment; Infant; Intervention; Investigation; Maternal Behavior; Measures; Mediating; Methods; Mood Disorders; Neuroendocrinology; Neurons; Neurosciences; Neurosecretory Systems; Parents; Paternal Behavior; Perception; Phase; Play; Postpartum Period; Process; Prolactin; Prolactin Receptor; Reporting; Research; Role; Sensory; Signal Transduction; Social outcome; Stimulus; System; Testing; Time; Visual; Woman; Work; antagonist; auditory discrimination; auditory processing; auditory stimulus; awake; behavioral response; career; cell type; density; economic outcome; hormone regulation; in vivo; insight; men; neural; neural circuit; neural patterning; neurodevelopment; novel; novel strategies; offspring; optogenetics; pharmacologic; programs; protective factors; receptor; response; sensory stimulus; sensory system; sex; skills; somatosensory; sound

PROJECT SUMMARY/ABSTRACT Does the way we hear sounds change when we become parents? This proposal will causally test if hormones involved in parental behavior affect the neural circuitry underlying offspring auditory cue processing in parents. It has long been known that offspring sensory cues, such as baby cries, elicit the necessary and appropriate behavioral responses from parents. How these sounds are encoded by the brain to elicit behavioral responses is not well understood. Men and women with postpartum mood disorders (PPMD) show lower neural responses to infant cries and subsequently display less or impaired parental behavior, leading to adverse child health and economical outcomes. Understanding how parental brain circuits are able to detect and respond to offspring sensory cues during a specific window of time (i.e., parenting) is imperative for developing novel interventions to effectively treat the unique impairments associated with PPMDs. Hormones play a crucial role in regulating parental behavior. However, we know little about how hormones affect the perception of sensory information from offspring. This proposal will test the hypothesis that prolactin, a hormone involved in both maternal and paternal behavior, interacts with auditory circuits to alter the sensory processing of offspring cues, in order to elicit parental behavior. Leveraging my expertise in prolactin’s role in parental care, I aim to gain new research skills to record and manipulate sensory neurons, which will facilitate the development of new approaches and directions of investigation for my research career. During the K99 phase I will use in vivo high-density electrophysiology to determine the patterns of neural responses to begging calls across the developmental period. I will then use in vivo optogenetics to manipulate auditory responses in order to establish causality of auditory processing on parental behavior. During the R00 phase, I will use these methods in combination with pharmacological manipulations of prolactin signaling to test the hypothesis that prolactin modulates these neural responses to offspring auditory cues in order to elicit appropriate parental behaviors. This research will serve as a launching point to develop a larger research program that investigates how multiple sensory systems (e.g., visual, somatosensory) interact together with the neuroendocrine system to regulate parental care. Investigations into the factors, networks, and cell-types that regulate parental auditory responsiveness in healthy parents will give the necessary insights into how these deficits can be ameliorated in parents with postpartum mood disorders.

项目摘要/摘要 当我们成为父母时，我们听到声音的方式会发生变化吗？该提议将因恐怖措施而发生因果测试 涉及父母行为会影响父母后代听觉提示处理的神经回路。 早就知道，后代的感官提示，例如婴儿哭泣，引起了必要和适当的 父母的行为反应。这些声音如何被大脑编码以引起行为反应 不太了解。有产后情绪障碍（PPMD）的男性和女人显示出较低的神经反应 婴儿哭泣，随后表现出较少或受损的父母行为，导致儿童健康不良，并 经济成果。了解父母大脑电路如何检测和响应后代 在特定时间窗口（即育儿）期间的感官提示对于开发新的干预措施至关重要 有效地治疗与PPMD相关的独特障碍。 激素在控制父母的行为中起着至关重要的作用。但是，我们对激素的了解一无所知 影响后代感官信息的感知。该提议将检验以下假设 催乳素是涉及母亲和父亲行为的马龙，与听觉电路相互作用 改变后代线索的感觉处理，以引起父母的行为。利用我的专业知识 在Prolactin在父母护理中的作用，我旨在获得新的研究技能，以记录和操纵感官神经元， 这将促进我研究生涯的新方法和投资方向的发展。 在K99期，I将使用体内高密度电生理学来确定神经元的模式 在整个发展时期对开始呼叫的回应。然后，我将使用体内光遗传学来操纵 听觉响应是为了建立关于父母行为的听觉处理的因果关系。在R00期间 阶段，我将使用这些方法与催乳素信号传导的药物操纵结合进行测试 催乳素调节这些神经对后代听觉线索的反应以引起的假设 适当的父母行为。这项研究将成为开发更大研究的发射点 研究多个感觉系统（例如，视觉，体感）如何与之相互作用的程序 神经内分泌系统以调节父母护理。调查对因素，网络和细胞类型的调查 规范健康父母中父母的听觉响应能力将提供必要的见解 产后情绪障碍的父母可以改善缺陷。