Assessing fentanyl test strip use accuracy and fentanyl presence in the non-heroin drug supply

评估芬太尼试纸的使用准确性和非海洛因毒品供应中芬太尼的存在

• 批准号: 10668083
• 负责人: Megan Reed
• 金额: $ 24.45万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668083
• 关键词: Acetaminophen; Address; Anticonvulsants; Benzodiazepines; Case Study; Cities; Consensus; Data; Drug usage; Drug user; Education Gap; Fentanyl; Goals; Harm Reduction; Heroin; Illicit Drugs; Interview; Knowledge; Laboratories; Law Enforcement; Length; Location; Low Prevalence; Methods; Municipalities; Outcome; Overdose; Patient Self-Report; Pennsylvania; Pharmaceutical Preparations; Philadelphia; Preparation; Prevalence; Prevention Measures; Prevention strategy; Process; Reporting; Research; Research Personnel; Sampling; Side; Stimulant; Syncope; Tablets; Technology; Testing; Time; Training; Water; Work; community organizations; community partnership; drug market; drug testing; evidence base; fentanyl contamination; fentanyl overdose; fentanyl test; fentanyl use; non-opioid analgesic; overdose prevention; overdose risk; prescription opioid; prevent; recruit; simulation; sugar; synthetic cannabinoid; test strip; tool

PROJECT ABSTRACT Fentanyl contamination of heroin and other drugs is increasingly common, leading to significant rates of unintentional fentanyl-related overdoses. Fentanyl test strips (FTS) are a low-threshold approach to mitigating fentanyl-related overdose risk among people who use drugs (PWUD). Using FTS, PWUD can dissolve a small quantity of a drug into water to test for the presence of fentanyl. PWUD report that FTS are easy to use with few logistical and environmental barriers associated with use. Moreover, emerging evidence indicates that FTS use positively impacts subsequent actions. In prior work conducted by our team, PWUD in Philadelphia reported exceptionally high rates of positive FTS results on non-heroin drugs, far higher than rates seen in other locations. Possible explanations for these discordant results include saturation of the Philadelphia illicit drug market with fentanyl, incorrect use of FTS, incorrect interpretation of FTS, or a combination of the three. Despite increasing distribution of FTS, no studies to date have explored the accuracy of FTS use by PWUD. In addition, while the prevalence of fentanyl in the heroin supply has been widely documented, it is currently unknown to what extent fentanyl is present in non-heroin drug markets. Based upon the recent findings in Philadelphia reporting alarmingly high rates of FTS positivity with non-heroin drugs and these gaps in current knowledge regarding both FTS use and contamination of the non-heroin drug supply, there is an urgent need to assess the accuracy of FTS use among PWUD and the extent fentanyl is present in the Philadelphia non- heroin drug supply. The long-term goal of this work is to advance overdose prevention measures using FTS and other drug-checking technology in drug markets around the U.S. The overall objective of this proposal is to leverage established municipal and community partnerships in Philadelphia and the use of advanced drug- checking technology to explicate gaps identified between previously detected levels of fentanyl in the drug supply and self-reported results from FTS use among PWUD in Philadelphia. Our objective will be achieved with two specific aims: (1) Determine user process of use and interpretation of FTS and (2) Estimate the true presence of fentanyl in the non-heroin drug supply in Philadelphia, PA. This study will have significant impact by addressing knowledge gaps regarding utility of FTS as a harm reduction strategy and providing actionable evidence regarding the extent of fentanyl presence in non-heroin drugs. We anticipate three outcomes from aims: (1) the identification of educational gaps in the proper use of FTS and interpretation of their results among PWUD, (2) point-in-time data for fentanyl contamination of non-heroin illicit drugs in Philadelphia, and (3) informing ongoing national campaigns to educate PWUD about FTS and overdose prevention strategies. Study findings will enhance evidence-based overdose prevention efforts targeted at supply-side fentanyl contamination and real-world FTS use practices by PWUD.

项目摘要 海洛因和其他药物的芬太尼污染越来越普遍，导致很高的比率 无意的芬太尼相关药物过量。芬太尼测试条（FTS）是缓解的低阈值方法 使用药物的人（PWUD）中，芬太尼相关的过量风险。使用FTS，PWUD可以溶解一个小的 将药物的数量纳入水中以测试芬太尼的存在。 PWUD报告FTS易于使用 很少有与使用相关的后勤和环境障碍。此外，新兴证据表明FTS 使用积极影响随后的动作。在我们的团队进行的先前工作中，费城的PWUD 报告的非英雄素药物的阳性阳性率异常高，远高于 其他位置。这些不一致结果的可能解释包括费城非法的饱和 芬太尼的药物市场，FTS的不正确使用，FTS的不正确解释或三个组合。 尽管FT的分布增加了，但迄今为止，尚未探索PWUD使用FT的准确性。在 此外，虽然芬太尼在海洛因供应中的流行率已被广泛记录，但目前是 非英雄药物市场中存在芬太尼在多大程度上未知。根据最近的发现 费城报道了非英雄药物的FTS阳性率令人震惊的高率，而这些差距 关于FTS使用和非英雄药物供应的污染的知识，迫切需要 为了评估PWUD中FT使用的准确性以及在费城非芬太尼存在的程度 海洛因药物供应。这项工作的长期目标是使用FTS推进预防过量措施 以及美国各地药品市场中的其他药物检查技术的总体目标是 利用费城建立的市政和社区伙伴关系，并使用先进的药物 - 检查技术以解释药物中先前检测到的芬太尼水平之间鉴定的差距 费城PWUD中FTS使用的供应和自我报告的结果。我们的目标将得到实现 有两个具体的目的：（1）确定用户使用和解释FTS的过程，（2）估计 宾夕法尼亚州费城的非英雄药物供应中存在芬太尼。这项研究将产生重大影响 通过解决有关FTS作为减少危害策略的知识差距，并提供可行的 关于非英雄药物中芬太尼存在程度的证据。我们预计会产生三个结果 目的：（1）在适当使用FTS中识别教育差距和对其结果的解释 在PWUD中，（2）费城非英雄素非法药物的芬太尼污染的时间点数据，以及 （3）告知正在进行的全国运动，以教育普瓦德有关FTS和预防过量策略。 研究结果将增强针对供应侧芬太尼的基于证据的过量预防工作 污染和现实世界中的FTS使用PWUD的实践。