University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)

爱荷华大学鹰眼智力与发育障碍研究中心 (Hawk-IDDRC)

• 批准号: 10669135
• 负责人: EDWIN TED G. ABEL
• 金额: $ 122.06万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-16 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669135
• 关键词: Adult; Affect; Animals; Basic Science; Behavior; Cellular Phone; Child; Child Abuse and Neglect; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Cognitive; Collaborations; Communication; Communities; Conceptions; Country; Development; Developmental Delay Disorders; Developmental Disabilities; Diagnosis; Down Syndrome; Early identification; Education; Educational workshop; Electrophysiology (science); Ensure; Environment; Environmental Risk Factor; Epigenetic Process; Family; Fostering; Foundations; Funding; Future; Genes; Genetic; Genetic Variation; Genomics; Goals; Government Officials; Human; Huntington Disease; Individual; Infrastructure; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Communication; Interdisciplinary Study; Intervention; Iowa; Joints; Journals; Knowledge; Language Development; Leadership; Life; Link; Longevity; Mentors; Midwestern United States; Mission; Neurodevelopmental Disability; Neurosciences; Newsletter; Parent-Child Relations; Patient Recruitments; Phenotype; Policy Maker; Population; Population Heterogeneity; Positioning Attribute; Pregnancy; Prevalence; Prevention; Prevention strategy; Productivity; Publications; RNA; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk Factors; Risk Marker; Rural; Rural Population; Scientist; Series; Services; Structure; Talents; Translational Research; Universities; autism spectrum disorder; biobank; clinical care; clinical translation; cost effective; disability; early childhood; effective intervention; epigenetic regulation; exome; experience; gene therapy; genome sequencing; human old age (65+); improved; in utero diagnosis; innovation; interdisciplinary collaboration; meetings; multidisciplinary; neural circuit; novel; organizational structure; pediatric patients; pollutant; premature; prenatal stress; prevent; programs; recruit; research facility; retention rate; rural setting; rural underserved; social media; telehealth systems; treatment trial; web site; whole genome

PROJECT SUMMARY: OVERALL This is a revised application to establish the University of Iowa “Hawkeye” Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC), Our mission is to provide an organizational structure that fully integrates basic and clinical research across the lifespan—from conception to adulthood—that is focused on the prevention, diagnosis, treatment, and amelioration of intellectual developmental disabilities (IDDs), tailored to an underserved rural population. The Hawk-IDDRC includes four components: 1) the Hawk-IDDRC Research Project will examine the interaction of genetic and epigenetic/environmental risks in young children with developmental disabilities, including autism, and integrate services from all four research Cores; 2) Four Research Cores will facilitate interdisciplinary and translational research, including: an Administrative Core (AC) that provides leadership to ensure cost-effective and rigorous IDD research, while inspiring interdisciplinary collaboration and innovation; a Clinical Translational Core (CTC), which will apply basic science discoveries into clinical settings by streamlining patient recruitment and phenotyping, biobanking, and implementing clinical trials for the development of novel treatments that can be employed across the lifespan; a Developmental Genomic/Epigenetics Core (DGC), which will use RNA/exome/whole genome sequencing to uncover intrinsic genetic variation and the contributions of extrinsic (environmental and experiential) factors on epigenetic regulation, and the association of these with IDD; and a Neurocircuitry and Behavior Core (NBC), which will assess both animal and human neural circuit development and function, electrophysiology, and behavior; a 3) a Dissemination and Communication Plan that ensures Hawk-IDDRC research is effectively communicated to the scientific community, educators, policy makers, government officials, and the public, in an engaging and timely manner; and 4) an Educational Program, involving basic and clinical scientists, trainees, the public, and IDD-affected families, and will feature monthly seminars, mentoring of young and talented investigators focused on IDD research, and an educational program aimed at the lay public and IDD community. The Hawk-IDDRC will integrate and capitalize upon strong existing resources in the Hawkeye State: 1) the nationally renowned Center for Disabilities and Development; 2) the Iowa Neuroscience Institute; 3) Iowa’s University Center for Excellence in Developmental Disabilities (UCEDD), and 4) the Iowa Leadership Education in Neurodevelopmental Disabilities (LEND) program. The Center will foster strong existing collaborations between basic and clinical scientists, as well as the IDD community and their families, and support 73 federally funded projects ($28 million per year). The stable, non-transitory rural population in Iowa and an interconnected telehealth system uniquely position Hawk-IDDRC investigators to conduct longitudinal, multi-generational research, for which the University of Iowa is renowned. By providing the infrastructure to direct these outstanding resources, the Hawk-IDDRC will become a leading force in the study of IDD.

项目摘要：总体 这是建立爱荷华大学“鹰眼”知识和发展的修订应用程序 残疾研究中心（HAWK-IDDRC），我们的使命是提供一个充分的组织结构 整个生命周期的基础和临床研究（从概念到成年）都集中在 智力发育障碍（IDDS）的预防，诊断，治疗和疗程，量身定制 到服务不足的农村人口。 Hawk-Iddrc包括四个组成部分：1）Hawk-iddrc 研究项目将研究幼儿遗传和表观遗传/环境风险的相互作用 具有发育障碍，包括自闭症和所有四个研究核心的综合服务； 2）四 研究核心将促进跨学科和翻译研究，包括：行政核心 （AC）提供领导才能确保具有成本效益和严格的IDD研究，同时鼓舞人心 跨学科的合作与创新；临床翻译核心（CTC），该核心将应用基本 科学通过简化患者招募和表型，生物群和 实施临床试验，以开发可以在整个生命周期中使用的新型治疗方法； 发育基因组/表观遗传学核心（DGC），它将使用RNA/外显/全基因组测序 发现内在的遗传变异以及外在（环境和专家）因素对 表观遗传调节，以及它们与IDD的关联；以及神经循环和行为核心（NBC）， 它将评估动物和人类神经回路的发展和功能，电生理学以及 行为; A 3）有效地确保Hawk-IDDRC研究的传播和沟通计划有效 与科学界，教育工作者，政策制定者，政府官员和公众交流 引人入胜的态度； 4）一个教育计划，涉及基础和临床科学家，学员， 公众和受IDD影响的家庭，并将每月下水道以年轻和才华横溢的指导 研究人员专注于IDD研究，以及针对外行公众和IDD的教育计划 社区。 Hawk-IDDRC将集成并利用鹰眼的大量现有资源 州：1）全国著名的残疾与发展中心； 2）爱荷华州神经科学研究所； 3）爱荷华州大学发展障碍卓越中心（UCEDD）和4）爱荷华州领导层 神经发育障碍教育（贷款）计划。该中心将促进强大的现有 基础科学家以及IDD社区及其家人之间的合作，以及 支持73个联邦资助的项目（每年2800万美元）。爱荷华州的稳定，非通用农村人口 以及互连的远程医疗系统独特地位置Hawk-Iddrc调查人员进行纵向， 爱荷华大学著名的多代研究。通过提供基础架构 指导这些杰出的资源，霍克·伊德德（Hawk-Iddrc）将成为IDD研究的主要力量。

项目成果

Right Tegmental Hemorrhage with Urinary Retention: A Case Report.

• DOI: 10.1159/000521328
• 发表时间: 2022-01
• 期刊: Case reports in neurology
• 影响因子: 0.7
• 作者: Tish MM;Boes AD;Geerling JC
• 通讯作者: Geerling JC

A practical guide for researchers and reviewers using the ABCD Study and other large longitudinal datasets.

• DOI: 10.1016/j.dcn.2022.101115
• 发表时间: 2022-06
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Saragosa-Harris, Natalie M.;Chaku, Natasha;MacSweeney, Niamh;Williamson, Victoria Guazzelli;Scheuplein, Maximilian;Feola, Brandee;Iniguez, Carlos;Demir-Lira, Ece;McNeilly, Elizabeth A.;Huffman, Landry Goodgame;Whitmore, Lucy;Michalska, Kalina J.;Damme, Katherine S. F.;Rakesh, Divyangana;Mills, Kathryn L.
• 通讯作者: Mills, Kathryn L.

Twitches emerge postnatally during quiet sleep in human infants and are synchronized with sleep spindles.

• DOI: 10.1016/j.cub.2021.05.038
• 发表时间: 2021-08-09
• 期刊: Current biology : CB
• 作者: Sokoloff G;Dooley JC;Glanz RM;Wen RY;Hickerson MM;Evans LG;Laughlin HM;Apfelbaum KS;Blumberg MS
• 通讯作者: Blumberg MS

Using fNIRS to evaluate ADHD medication effects on neuronal activity: A systematic literature review.

使用 fNIRS 评估 ADHD 药物对神经元活动的影响：系统文献综述。

• DOI: 10.3389/fnimg.2023.1083036
• 发表时间: 2023
• 期刊: Frontiers in neuroimaging
• 作者: Poliakova,Eva;Conrad,AmyL;Schieltz,KellyM;O'Brien,MatthewJ
• 通讯作者: O'Brien,MatthewJ

Parenting a Child with a Neurodevelopmental Disorder during the Early Stage of the COVID-19 Pandemic: Quantitative and Qualitative Cross-Cultural Findings.

• DOI: 10.3390/ijerph20010499
• 发表时间: 2022-12-28
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Mazzoni, Noemi;Bentenuto, Arianna;Filosofi, Fabio;Tardivo, Angela;Strathearn, Lane;Zarei, Kasra;De Falco, Simona;Venuti, Paola;Iandolo, Giuseppe;Giannotti, Michele
• 通讯作者: Giannotti, Michele