Neurophysiological reward responsiveness, stress, and depressive symptoms across the perinatal period

整个围产期的神经生理奖赏反应、压力和抑郁症状

• 批准号: 10669099
• 负责人: Samantha Pegg
• 金额: $ 3.17万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669099
• 关键词: Adolescent; Adult; Animals; Antidepressive Agents; Award; Biological; Child; Childbirth; Clinical; Clinical Research; Cognitive; Complex; Data; Data Collection; Development; Diagnostic; Dorsal; Electroencephalography; Emotional; Estrogens; Event-Related Potentials; Feedback; Fellowship; Frequencies; Goals; Grant; Grooming; Hormones; Hydrocortisone; Impairment; Infant; Intervention; Interview; Knowledge; Life Stress; Link; Literature; Longitudinal Studies; Maintenance; Maternal Behavior; Measures; Mental Depression; Methods; Modeling; Mood Disorders; Mothers; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Perinatal; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Prevention; Process; Productivity; Progesterone; Research; Research Project Grants; Research Support; Research Training; Rewards; Risk; Risk Factors; Safety; Sampling; Scientist; Second Pregnancy Trimester; Social Impacts; Statistical Methods; Stress; Stress Tests; System; Testing; Third Pregnancy Trimester; Time; Training; Training Support; Ventral Striatum; Visit; Woman; Work; antepartum depression; barrier to care; career; depressive symptoms; experience; feeding; financial incentive; functional disability; high risk; innovation; neural; neuroimaging; neurophysiology; offspring; perinatal period; peripartum depression; pre-doctoral; preventive intervention; prospective; research study; response; skills; social; social stigma; stress symptom; suicidal risk

PROJECT SUMMARY/ABSTRACT Perinatal depression (i.e., depression during pregnancy and following childbirth) is a prevalent and debilitating condition that is associated with significant impairments in maternal functioning and negative impacts on offspring, making the identification of targets for prevention critically needed. Neuroscience research outside of the perinatal period has shown a prospective association between reduced neural reward responsiveness and depression, but the extent to which depression further alters reward responsiveness has yet to be examined. The perinatal period presents a unique time of adaptations of the reward system which have implications for the development of depression, but neuroscience research has primarily been limited to the postpartum period due to concerns about the safety of neuroimaging during pregnancy. Stress has been shown both to reduce reward responsiveness and moderate effects of low reward responsiveness on depression, adding further complexity to pathways to depression across time. Given the added stress and unique biological changes associated with reward system adaptations, longitudinal work is needed to understand pathways through which women develop perinatal depression. As part of a larger project, this research study will use safe and temporally sensitive methods to measure neural reward responsiveness, stress, and depressive symptoms in 100 pregnant women at 20 weeks gestation, 34 weeks gestation, and 8 weeks postpartum. At each assessment, participants will complete a monetary incentive delay task while electroencephalogram is recorded in response to reward and loss feedback. Event-related potential (e.g., the reward positivity, a reliable time-domain measure of initial reward responsiveness) and time-frequency data (i.e., delta and theta activity, frequency-domain markers of sensitivity to rewards and negative outcomes, respectively) will be used to measure neurophysiological response to reward. Participants will complete self-report and interview measures of depressive symptoms and stress at each visit. Through the longitudinal collection of these data, the present research will examine longitudinal associations between reduced reward responsiveness and depression using an innovative bidirectional model to tease apart directionality of these associations across time (Specific Aim 1). This work will also test stress as a moderator of the associations between reward responsiveness and depressive symptoms across the perinatal period (Specific Aim 2). This predoctoral fellowship award will bring together a team of experts in their respective fields and allow for advanced training in life stress assessment, perinatal depression and risk, EEG time-frequency analysis, and quantitative methods. Together, the research project and training will provide the fellow the opportunity to develop necessary skills for a productive career as a clinical scientist investigating alterations in emotional and social processing and how these processes contribute to the development of mood disorders to inform intervention.

项目摘要/摘要 围产期抑郁症（即怀孕期间和分娩后的抑郁症）是一个普遍且令人衰弱的 与孕产妇功能的重大损害相关的状况和对 后代，确定迫切需要预防目标的目标。神经科学研究以外 围产期表明，神经奖励反应能力降低与 抑郁症，但抑郁症进一步改变奖励响应能力的程度尚未得到研究。 围产期时期呈现了奖励系统的独特时间，这对 抑郁症的发展，但神经科学研究主要仅限于产后时期 由于担心怀孕期间神经影像的安全性。压力已被证明两者都可以减少 奖励响应能力和低奖励反应能力对抑郁症的中等影响，进一步增加 随着时间的流逝，通往抑郁症的途径的复杂性。考虑到增加的压力和独特的生物学变化 与奖励系统的适应相关，需要纵向工作才能理解途径 妇女患围产期抑郁症。作为一个较大项目的一部分，这项研究将使用安全和 在时间上敏感的方法来测量神经奖励反应能力，压力和抑郁症状 妊娠20周时，有100名孕妇，妊娠34周和产后8周。每个 评估，参与者将完成一项货币激励延迟任务，而脑电图为 记录是为了响应奖励和损失反馈。与事件相关的潜力（例如，奖励积极性，可靠的 初始奖励响应能力的时间域度量）和时频数据（即，三角洲和theta活动， 对奖励和负面结果的敏感性的频率域标记将用于 测量对奖励的神经生理反应。参与者将完成自我报告和面试措施 每次访问时都有抑郁症状和压力。通过这些数据的纵向集合，目前 研究将检查使用降低的奖励反应能力和使用抑郁症之间的纵向关联 一种创新的双向模型，可以嘲笑这些关联的方向性（特定目的 1）。这项工作还将测试压力，以作为奖励响应能力与 整个围产期期间的抑郁症状（特定目标2）。该奖学金奖学金将带来 一组专家团队在各自领域，允许在生活压力评估中进行高级培训， 围产期抑郁和风险，脑电图时间频率分析和定量方法。一起研究 项目和培训将为同伴提供机会，以发展成果职业的必要技能 临床科学家调查情绪和社会处理的变化以及这些过程如何 为情绪障碍的发展做出贡献，以告知干预措施。

项目成果

Behavioral and psychiatric correlates of brain responses to social feedback.

大脑对社会反馈的反应的行为和精神相关性。

• DOI: 10.1111/psyp.14413
• 发表时间: 2024
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Rappaport,BrentI;Kujawa,Autumn;Arfer,KodiB;Pegg,Samantha;Kelly,Danielle;Jackson,JoshuaJ;Luby,JoanL;Barch,DeannaM
• 通讯作者: Barch,DeannaM