Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach

牙周组织再生的个性化策略——融合生物制造方法

基本信息

批准号：
10668946
负责人：
Marco C Bottino
金额：
$ 50.11万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668946
关键词：
3-Dimensional Address Adopted Affect American Animal Model Architecture Bacteria Biocompatible Materials Biological Process Bone Growth Ceramics Chemicals Chronic Clinical Data Defect Dental Cementum Dentition Development Disease Engineering Fiber Genes Goals Growth and Development function In Vitro Inflammatory Ink Lasers Left Magnesium Mechanics Medicine Morphology Mouth Diseases Nanostructures Natural regeneration Nature Patients Periodontal Ligament Periodontic specialty Periodontitis Physiological Polymers Printing Role Silver Structure Surface Technology Therapeutic Tissues Tooth Extraction Tooth Loss Tracheobronchomalacia Translating Translations alveolar bone antimicrobial biofabrication bone bone engineering bone loss bone scaffold calcium phosphate coating canine model clinical efficacy clinically relevant design efficacy evaluation fabrication human old age (65+)improved in vivo in vivo Model innovation inorganic phosphate manufacture melting novel personalized medicine personalized strategies regenerative therapy scaffold tissue regeneration tool

项目摘要

” Periodontitis (gum disease) is a ubiquitous chronic inflammatory, bacteria-triggered oral disorder affecting two-thirds of Americans over age 65. If left untreated, it leads to severe destruction of the periodontal attachment apparatus, eventually resulting in tooth loss. There are no approaches for predictably regenerating defects with severe bone loss and avoiding tooth extraction. Thus, there is an emerging quest for personalized solutions that can guide coordinated growth and development of the periodontal attachment apparatus. We hypothesize that: (1) Melt ElectroWriting (MEW) is the fabrication tool required to develop a compositionally and structurally tailored, tissue-specific scaffold to hearten bone growth and PDL formation on root surfaces with moderate adjacent bone; and (2) the convergence of MEW with ceramic printing is key to engineering a compositionally graded and structurally tailored scaffold to support bone growth while guiding PDL formation on root surfaces with minimum adjacent bone. Two aims are proposed. Aim 1 will optimize a personalized, compositionally and structurally tailored, tissue-specific polymeric scaffold to regenerate defects with moderate surrounding bone. Aim 2 will develop a personalized, compositionally graded and structurally tailored, tissue-specific multi-material scaffold to regenerate defects with minimum surrounding bone. To expedite translation, we will determine efficacy using our clinically relevant animal models. Successful completion of this project is central to translating personalized therapies to treat tissue destruction caused by periodontitis and thus saving millions of teeth from extraction.

透明牙周炎（牙龈疾病）是一种普遍存在的慢性炎症性，细菌触发的口腔疾病，影响65岁以上的美国人中三分之二的美国人。如果不进行治疗，它会严重破坏牙周附着设备，最终导致牙齿脱落。没有方法可以预测地再生缺陷，并避免拔牙。这是一个新兴的寻求个性化解决方案的追求，可以指导牙周依恋设备的协调增长和发展。我们假设：（1）融化电工（MEW）是开发合成和结构定制的，组织特异性支架的制造工具，以在具有中等相邻骨骼的根部表面上进行心脏的骨骼生长和PDL形成；（2）MEW与陶瓷印刷的收敛是工程均等级别和结构定制的脚手架的关键，以支持骨骼生长，同时指导PDL在具有最小相邻骨骼的根表面上形成。提出了两个目标。 AIM 1将优化一个个性化的，合成和结构定制的组织特异性聚合物支架，以使周围骨骼中等的缺陷再生。 AIM 2将开发一个个性化的，合成的分级和结构定制的，组织特异性的多物质支架，以最小的骨骼再生缺陷。为了加快翻译，我们将使用临床相关的动物模型来确定有效性。该项目的成功完成是转化个性化疗法以治疗由牙周炎引起的组织破坏的核心，从而使数百万颗牙齿免于提取。