Data and Analytics Core

数据和分析核心

基本信息

批准号：
10633143
负责人：
AMBER L. MOSLEY
金额：
$ 24.61万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10633143
关键词：
Animal Model Atherogenic Diet Biotechnology Body Composition Breeding Calories Catheters Chemicals Cholesterol Clinical Medicine Collaborations Complex Control Groups Corvus Data Diabetes Mellitus Diet Dyslipidemias Endocrine Family suidae Fasting Funding Glucose Glucose Clamp Health High Density Lipoproteins Human Implant Indiana Informatics Insulin Resistance Intervention Intravenous Kidney Calculi Licensing Lipids Lithotripsy Liver Low-Density Lipoproteins Medicine Metabolic Metabolic syndrome Metabolism Methods Microscopy Miniature Swine Modeling Molecular Monitor National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases Non-Insulin-Dependent Diabetes Mellitus Oral Pathogenesis Phenotype Physiology Positron-Emission Tomography Production Research Research Personnel Resource Sharing Resources Rodent Services Severities Skeletal Muscle Stents System Testing Therapeutic Thinness Tissue Banks Tissues Transgenic Mice Translational Research Translations Triglycerides Ultrasonography Universities X-Ray Computed Tomography bariatric surgery comorbidity comparative cost effectiveness cost efficient data repository diabetic human disease human model imaging study impaired glucose tolerance improved in vivo indexing islet medical schools metabolic abnormality assessment mouse model operation translation to humans

项目摘要

ABSTRACT (SWINE CORE) The Swine Core of the Indiana Diabetes Research Center is a Regional/National Shared Resource Core that has been operating and servicing researchers since 2004. The central function of the Swine Core is to reduce barriers to the use of Ossabaw swine, a unique animal model that closely approximates human metabolic syndrome (MetS) and progression to type 2 diabetes, with attendant long-term complications. Understanding and therapeutic treatment of MetS and diabetes with numerous long-term health complications in humans has been stifled by the lack of translational animal models. Experimental methods and translation to human clinical medicine is not possible from widely used rodent and transgenic mouse models. The Swine Core will characterize MetS and progression to type 2 diabetes and/or chemically-induced diabetes (MetS/D) and the resulting comorbidities in Ossabaw swine. We have provided Ossabaw tissue and/or live pigs to ~160 investigators during the 15 years of the Swine Core operation. A bank of ~50 different tissues available from each pig has enabled widespread dissemination to other investigators, providing outstanding resource sharing and cost-effectiveness. Providing this swine resource enables testing of numerous hypotheses about the integrated, in vivo pathogenesis and long-term complications and provides tissues for studies of cellular and molecular mechanisms. The Swine Core is a critical interface in the translation of research from simpler animal models (Islet & Physiology Core) to humans (Translation Core). The Swine Core is Directed by Dr. M. Sturek, a leader in modeling human diseases in swine, and Dr. M. Alloosh serves as the Associate Director. The Specific Aims of the Swine Core are to: (1). Make lean and diet-induced MetS and diabetic (MetS/D) pigs readily available, i.e. “on the shelf”. (2). Determine the endocrine, metabolic, and dyslipidemia indices of MetS/D to screen for optimal phenotypes. (3). Provide a tissue and data bank for distribution. These aims of the Swine Core will reduce barriers to study of this highly relevant animal model, and will facilitate the progressive translation of research from simpler, less complex models to humans.

摘要（猪核）印第安纳州糖尿病研究中心的猪核心是区域/国家共享资源核心自2004年以来一直在运营和维修研究人员。猪核心的核心功能是减少使用Ossabaw Swine的障碍，Ossabaw Swine是一种独特的动物模型，非常接近人类代谢综合征（MetS）和2型糖尿病的进展，包括随之而来的长期汇编。在人类中对Mets和糖尿病进行大量长期健康汇编的治疗治疗由于缺乏转化动物模型而扼杀了人类的临床方法从广泛使用的啮齿动物和转基因小鼠模型中不可能进行药物。表征2型糖尿病和/或化学性诱导的糖尿病（Mets/d）和Thee的Mets和进展在Ossabaw猪中重新校友。研究人员在猪核心操作的15年中。每头猪都可以向其他调查人员进行广泛的传播，提供出色的资源共享和成本效益。综合，体内发病机理和长期汇编，并为细胞和研究提供组织分子机制。人类的模型（胰岛和生理核心）（翻译核心）。在猪中建模人类疾病的领导者和博士猪核的具体目的是：（1）使瘦肉和饮食诱发的糖尿病（Mets/d）可用，即“在架子上”。（2）。表型。（3）。猪芯的SE目标将减少这种OFET动物模型的障碍，并将从更简单，更复杂的模型向人类进行研究的逐步翻译。