Study to Explore Early Development (SEED) Follow up Studies, Components A, B, D & E

探索早期发育的研究 (SEED) 后续研究，组成部分 A、B、D

• 批准号: 10633217
• 负责人: Christine Ladd-Acosta
• 金额: $ 136.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633217
• 关键词: Study; Explore; Early; Development; SEED

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case-control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co-occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The Maryland SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in Maryland and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

自闭症谱系障碍（ASD）是一种神经发育障碍，影响约1.5％的儿童 在美国。在社会传播或限制利益方面具有ASD经验辩护的个人， 重复行为；但是，严重性和模式差异很大，并传达了某些人的终生障碍。这是 尚不清楚ASD的介绍如何从幼儿期变为青少年或成年。原因 ASD也未知，尽管大量证据支持基因和基因的贡献 环境因素。存在这些知识差距，因为迄今为止的美国研究缺乏样本量， 数据收集的深度或适当的生活课程时机以解决这些问题。早期探索的研究 开发（种子）现在能够解决这些先前的限制。种子是一项大型案例对照研究 2-5岁的儿童及其家人在三个阶段的八个州实施。种子收集 有关儿童核心ASD症状，认知状况以及存在同时发生条件的详细数据 幼儿期，以及与母子健康和围产期环境有关的广泛危险因素 以及基因组学。种子样本包括2044名ASD儿童，1950年非ASD儿童 发育障碍（DD）和2285个人口控制儿童（POP），使其成为最大的病因 在美国的ASD研究。最近的辅助研究 - 种子青少年飞行员和种子互联研究 - 很快将 分别为某些种子参与者添加有关青少年健康和大流行的后果的数据。 这里提出的工作，种子后续研究（种子FU）将最大程度地提高额外种子数据的影响 通过表征ASD表型的分析，并评估遗传和遗传之间的潜在相互作用 可修改的风险因素。种子FU还将促进中期的童年，青少年和 成年早期表征整个发育阶段ASD表型的变化，以及相关的 早期生活课程的健康，教育和服务需求。这些数据将进一步实现潜在的 对早期生命因素与后期成年早期结局之间的关联的分析。 研究与生活课程相关的危险因素表型亚组也可能有助于先前阐明病因 在ASD病例对照研究中掩盖。马里兰州种子团队与种子网络的结合 协作基础架构和广泛的扩展数据资源将确保成功实施 马里兰州的种子FU研究为整个网络的成功做出了贡献。种子驱动力量 对我们对复杂自闭症表型和识别相关因素的理解的重要贡献 人口中的ASD风险。种子FU获得的知识将大大提高我们的能力 不利的发展成果并支持ASD及其家人的个人以确保最佳 在成年初期的福祉。