Project 1 - Defining the structure and function of NTS satiety circuits

项目 1 - 定义 NTS 饱腹感电路的结构和功能

基本信息

批准号：
10667320
负责人：
Martin G Myers
金额：
$ 41.97万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10667320
关键词：
Acute Agonist Animals Anorexia Appetite Stimulants Body Weight Body Weight decreased Brain Stem Calcitonin Calcitonin Receptor Cell Nucleus Cells Cholecystokinin Chronic Consumption Development Diet Eating Feeding behaviors Food Food Energy GLP-I receptor Genes Genetic Hypothalamic structure Ingestion Maintenance Mediating Metabolic Diseases Motivation Mus Nature Nausea Negative Valence Neurons Nutrient Nutritional Obesity Pharmaceutical Preparations Physiological Physiology Positive Reinforcements Positive Valence Production Proteins Receptor Cell Research Satiation Signal Transduction Stimulus Structure of dorsomedial hypothalamic nucleus Structure/Function Nuclei Symptoms System Taste Perception Techniques Testing Toxin Visceral cell type combat design energy balance feeding food restriction gut-brain axis hindbrain improved inhibitory neuron irritation leptin receptor neural neural circuit neuromechanism obesity treatment optogenetics pharmacologic response restraint targeted treatment transmission process

项目摘要

Abstract Project 1- Project 1: Defining the structure and function of NTS satiety circuits While much recent energy balance-directed research has focused upon hypothalamic circuits, these hypothalamic systems largely mediate their effects on feeding via hindbrain circuits. Furthermore, many of the most effective pharmacological obesity treatments act on brainstem satiety systems. The inadvertent production of aversive symptoms such as nausea, which is mediated by circuits that are intermingled with brainstem satiety systems, represents one of the most important limitations to therapies that target these systems, however. Thus, it will be crucial to distinguish the brainstem circuits that encode satiety from those that promote nausea and other aversive symptoms, since the non-aversive circuits represent ideal targets for therapy. This project will define the neural circuits by which the NTS controls feeding and by which it signals aversive or non-aversive responses, as appropriate for the stimulus. In addition to enhancing our understanding of neural systems important for the control of ingestive behavior, distinguishing non-aversive from aversive satiety systems may permit the design of improved therapies to decrease food intake and combat obesity.

摘要项目1-项目1：定义NTS饱腹感电路的结构和功能虽然最近许多以能量平衡为导向的研究都集中在下丘脑这些下丘脑系统主要通过后脑回路介导其对进食的影响。此外，许多最有效的药物肥胖治疗方法都作用于脑干饱腹感系统。无意中产生恶心等厌恶症状，由与脑干饱腹感系统混合的电路介导，代表了一种然而，针对这些系统的治疗的最重要的限制。因此，这将是至关重要的区分编码饱腹感的脑干回路和促进恶心等的脑干回路厌恶症状，因为非厌恶回路代表了理想的治疗目标。该项目将定义 NTS 控制进食的神经回路以及它根据刺激发出厌恶或非厌恶反应的信号。此外增强我们对控制摄入行为重要的神经系统的理解，区分非厌恶性和厌恶性饱足系统可能允许设计改进的减少食物摄入和对抗肥胖的疗法。