Silybin as an anti-inflammatory and anti-fibrotic agent in cancer cachexia

水飞蓟宾作为癌症恶病质的抗炎和抗纤维化剂

• 批准号: 10665485
• 负责人: Mitzi Nagarkatti
• 金额: $ 17.86万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10665485
• 关键词: Anti-Inflammatory Agents; Body Weight decreased; Cachexia; Cessation of life; Chronic Disease; Cicatrix; Deterioration; Fatty acid glycerol esters; Fibrosis; Health; Heart Diseases; Inflammation; Lead; Liver diseases; Locomotion; Malignant Neoplasms; Medicinal Plants; Milk Thistle; Muscle; Muscle function; Muscular Atrophy; Myopathy; Neuromuscular Diseases; Patients; Performance; Persons; Phase; Physical Function; Property; Quality of life; Skeletal Muscle; Tissues; Trauma; antifibrotic treatment; cancer cachexia; cancer therapy; dietary supplements; improved; muscle form; novel strategies; prevent; sarcopenia; silibinin; systemic inflammatory response; treatment response

Unintentional body weight loss (cachexia) in chronic diseases, such as cancer can lead to the deterioration of quality of life, lack of response to treatment, and ultimately death. Cancer cachexia is characterized by systemic inflammation, muscle and fat loss, and reduced physical function. Tissue fibrosis or scarring has been observed in cancer cachectic patients. Muscle fibrosis is one of the most consistent findings among people with reduced muscle function due to myopathies, neuromuscular disorders, trauma, and sarcopenia. Blocking inflammation and fibrosis in the pre-cachectic and cachectic stages is critical to positively impact muscle health, locomotion, and performance. Silybin, one of the active compounds of the medicinal plant Silybum marianum has shown anti-inflammatory and anti-fibrotic properties in cardiac and liver disorders. Since there are no approved therapies for cancer cachexia and silybin has been associated to improve factors associated with cachexia, we propose to assess whether silybin reduces skeletal muscle fibrosis. Furthermore, we will determine if TGF-􀈕 is involved in initiating or maintaining loss of muscle mass and function. Our findings could lead to the discovery of a new mechanism and novel strategies to prevent and/or treat cachexia.

癌症等慢性疾病导致的无意体重减轻（恶病质）可导致 生活质量恶化、治疗缺乏反应，最终导致死亡。 其特征是全身炎症、肌肉和脂肪减少以及身体机能下降。 在癌症恶病质患者中观察到纤维化或疤痕，肌肉纤维化是最常见的纤维化之一。 在因肌病、神经肌肉疾病而导致肌肉功能下降的人群中得到了一致的发现 阻止恶病质前和恶病质中的炎症和纤维化。 阶段对于积极影响肌肉健康、运动和表现至关重要，水飞蓟宾是其中之一。 药用植物水飞蓟的活性化合物具有抗炎和抗纤维化作用 由于尚无批准的治疗癌症恶病质和癌症的疗法。 水飞蓟宾与改善恶病质相关的因素有关，我们建议评估是否 此外，我们将确定 TGF-☆ 是否参与启动或参与。 我们的发现可能会导致新的发现。 预防和/或治疗恶病质的机制和新策略。