Early-life Exposure to Secondhand Smoke and Childhood Obesity

早年接触二手烟和儿童肥胖

• 批准号: 10669409
• 负责人: Brianna F Moore
• 金额: $ 22.81万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-03 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669409
• 关键词: Early; life; Exposure; Secondhand; Smoke

Secondhand smoke is a common early-life exposure that may contribute to future risk for obesity. Epidemiologic studies have consistently reported positive associations between prenatal or postnatal exposure to secondhand smoke with childhood obesity. However, very few studies have attempted to disentangle the effects of prenatal and postnatal exposures or have incorporated a tobacco-specific biomarker of exposure. Furthermore, the mechanisms underlying the secondhand smoke-obesity associations are unknown. The goal of this project is to explore the timing and mechanisms of the previously observed associations between exposure to secondhand smoke and obesity, incorporating 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a novel and potentially more accurate indicator of exposure. Understanding when and how exposure to secondhand smoke impacts obesity risk may inform new public health strategies with potential relevance for both smoking cessation and obesity prevention. During the training phase of this award, Dr. Moore will use didactic instruction, individually mentored training, and independent study to develop expertise in three content areas: 1) secondhand smoke exposure assessment; 2) nutritional epidemiology; and 3) advanced statistical methods. This training will be applied to a research project that will leverage the resources and infrastructure of an ongoing, longitudinal cohort of 1,410 mother-child pairs (Healthy Start, R01DK076648, PI: Dabelea), which was recently included in the Environmental Influences on Child Health Outcomes (ECHO) consortium (1UG3OD023248-01; PI: Dabelea). She will examine the association of prenatal and postnatal exposures to secondhand smoke with repeated measures of adiposity from birth to 5 years (Aim 1). During the independent phase of this award, Dr. Moore will validate the data yielded from Aim 1 by using NNAL to characterize exposure to secondhand smoke. She will then explore the extent to which the secondhand smoke-obesity associations are mediated by oxidative stress and inflammation or modified by early-life nutrition and socioeconomic status (Aim 3). Dr. Moore is well-equipped to perform this research based on: 1) her research background and interests investigating the impact of exposures to environmental chemicals on childhood obesity; 2) her access to the unique, well-characterized Healthy Start cohort, which will allow for an in-depth exploration of the timing and mechanisms of the secondhand smoke-obesity associations; and 3) her access to the extensive resources provided by her mentorship team and institution. The proposed research and training plan will prepare her for an independent career examining the impact of environmental exposures on childhood metabolic disorders.

二手烟是一种常见的生命早期暴露方式，可能会增加未来肥胖的风险。 流行病学研究一致报告产前或产后暴露之间存在正相关 二手烟与儿童肥胖有关。然而，很少有研究试图解开这一问题 产前和产后暴露的影响或纳入了烟草特异性暴露生物标志物。 此外，二手烟与肥胖关联的机制尚不清楚。目标 该项目的目的是探索先前观察到的之间关联的时间和机制 接触二手烟和肥胖，掺入 4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇 （NNAL），一种新颖且可能更准确的暴露指标。了解何时以及如何暴露 二手烟影响肥胖风险可能会为新的公共卫生战略提供信息，并与以下方面潜在相关： 戒烟和预防肥胖。 在该奖项的培训阶段，摩尔博士将使用教学指导，单独指导 培训和独立研究，以发展三个内容领域的专业知识：1）二手烟暴露 评估; 2）营养流行病学； 3）先进的统计方法。本次培训将应用于 该研究项目将利用 1,410 名正在进行的纵向队列的资源和基础设施 母子对（Healthy Start，R01DK076648，PI：Dabelea），最近被纳入 环境对儿童健康结果的影响 (ECHO) 联盟（1UG3OD023248-01；PI：Dabelea）。 她将研究产前和产后接触二手烟与反复接触二手烟的关系。 从出生到 5 岁的肥胖测量（目标 1）。在该奖项的独立阶段，摩尔博士将 使用 NNAL 描述二手烟暴露特征，验证目标 1 产生的数据。她会 然后探讨二手烟与肥胖之间的关联在多大程度上是由氧化应激介导的 和炎症或通过生命早期营养和社会经济状况进行改变（目标 3）。 Moore 博士有能力开展这项研究，基于：1) 她的研究背景和 有兴趣调查环境化学物质暴露对儿童肥胖的影响； 2）她的访问权限 独特的、特征鲜明的健康开始队列，这将允许深入探索时机 二手烟与肥胖协会的机制； 3）她可以获得广泛的资源 由她的导师团队和机构提供。拟议的研究和培训计划将为她做好准备 一项独立的职业，研究环境暴露对儿童代谢紊乱的影响。