Summer Vision Sciences Training Program

夏季视觉科学培训计划

基本信息

批准号：
10630145
负责人：
BRIAN P. CERESA
金额：
$ 3.31万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630145
关键词：
Authorship Basic Science Biology Clinical Clinical Research Conflict of Interest Data Education Environment Faculty Female Foundations Funding Goals Homeostasis Hour Institutional Review Boards Interview Laboratories Laboratory Research Medical Students Mentors Mentorship Ophthalmology Physicians Plagiarism Productivity Publications Research Research Personnel Research Project Grants Research Training Retinal Degeneration Science Scientist Series Structure Student recruitment Students Systems Development Time Training Training Programs Translational Research Universities Uveitis Vision Vision research Visual Work animal care career corneal epithelium design disadvantaged background drug discovery ethnic minority experience fabrication human subject medical schools peer posters programs responsible research conduct skills vision development vision science

项目摘要

Project Summary/Abstract This is a renewal application for a T35 summer medical student training program in vision research with two Specific Aims: 1) To provide hands-on training in basic and clinical vision research to medical students in a structured mentored environment and 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical research in vision biology. The co-directors of this program request support for 8 second-year medical students each summer in vision related research laboratories that focus on topics such as visual circuitry, retinal degeneration, corneal epithelial homeostasis, uveitis, ocular drug discovery, and development of the visual system. Trainees will be selected from the first-year class at University of Louisville School of Medicine. Students will review research projects submitted by 18 faculty funded by the NEI or vision related foundations. The directors will make a special effort to recruit students who are underrepresented in science, including females, ethnic minorities and from disadvantaged backgrounds. Students will review the available projects and rank their 1st-5th choices, allowing matching of trainees with mentors. Final decisions will be made based on interviews between mentors and Trainees. During the 10-week summer training, students work with mentors on their research project in laboratory settings, complete training in the Responsible Conduct of Research including topics such as fabrication and falsification of data, plagiarism, managing scientific data, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees will complete human subject, IRB training, and animal care and handling as required by their specific research projects. All Trainees will attend a 2-hour weekly “Vision Sciences Research Training Seminar” designed to introduce clinical/translational research in Ophthalmology led by mentors in this T35 program. The seminar series will culminate with each Trainee presenting his/her research project to peers and mentors. In addition, trainees present the results of their research as posters with peers at a School of Medicine-wide, week-long celebration of research (Research!Louisville) that includes nationally recognized physician-scientists as keynote speakers. Trainees will be encouraged to continue research as part of the Distinction in Research track that is an enrichment program focusing on providing meaningful and productive research experiences throughout second through fourth years of medical school, with ongoing presentations by students with mentors and 4+ weeks of research time in the fourth year toward the goal of developing clinician-researchers. Trainees will be tracked to assess the impact of this T35 program on careers as physician-scientists.

项目概要/摘要这是 T35 夏季医学生视觉研究培训项目的续签申请两个具体目标： 1) 为医学界提供基础和临床视觉研究的实践培训学生处于结构化的指导环境中，2) 提供互动的教育体验向医学生介绍基础、转化和临床所需的基本技能该项目的联合主任请求支持 8 名二年级医学生。每年夏天，学生都会在视觉相关的研究实验室里学习，重点研究视觉等主题电路、视网膜变性、角膜上皮稳态、葡萄膜炎、眼部药物发现和视觉系统开发的学员将从大学一年级中选拔。路易斯维尔医学院的学生将审查由 18 名教师提交的研究项目。 NEI 或视觉相关基金会的董事将特别努力招收符合以下条件的学生。科学界的代表性不足，包括女性、少数民族和弱势群体学生将审查可用的项目并对他们的第一至第五个选择进行排名，以便进行匹配。学员与导师的最终决定将根据导师和导师之间的访谈做出。在为期 10 周的暑期培训中，学生与导师一起完成他们的研究项目。实验室设置、负责任的研究行为的完整培训，包括以下主题捏造和伪造数据、剽窃、科学管理数据、出版实践和受训者将完成责任权力、指导、管理和利益冲突。主题、IRB 培训以及特定研究项目要求的动物护理和处理。学员将参加每周 2 小时的“视觉科学研究培训研讨会”，旨在介绍由 T35 项目导师领导的眼科临床/转化研究。研讨会系列将在每位学员向同行和同事展示他/她的研究项目时达到高潮此外，学员还将他们的研究成果以海报的形式与学院的同行们一起展示。为期一周的全医学研究庆祝活动（研究！路易斯维尔），包括全国范围内将鼓励受训者继续研究。作为“杰出研究”轨道的一部分，该轨道是一项强化计划，专注于提供医学第二年至第四年的有意义且富有成效的研究经历学校，学生在导师的指导下进行持续的演讲，并在该校进行 4 周以上的研究时间第四年，将跟踪学员以评估其发展临床医生研究人员的目标。此 T35 计划对医师科学家职业的影响。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.

DOI：
10.1167/iovs.64.10.22
发表时间：
2023-07-03
期刊：
Investigative ophthalmology & visual science
影响因子：
4.4
作者：
通讯作者：

Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.

造血干细胞移植后供体睑脂的结构差异。

DOI：
10.1097/ico.0000000000001935
发表时间：
2019
期刊：
Cornea
影响因子：
2.8
作者：
Ramasubramanian,Aparna;Blackburn,Ryan;Yeo,Heegook;Sledge,SamiyyahM;Gully,ZaharaN;Singh,Sharika;Mehta,Sanya;Mehta,Aakash;Yappert,MartaC;Borchman,Douglas
通讯作者：
Borchman,Douglas

Differences in Meibum and Tear Lipid Composition and Conformation.

DOI：
10.1097/ico.0000000000002095
发表时间：
2020-01
期刊：
Cornea
影响因子：
2.8
作者：
Borchman D;Ramakrishnan V;Henry C;Ramasubramanian A
通讯作者：
Ramasubramanian A

Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility.

DOI：
10.1038/s42003-023-04831-0
发表时间：
2023-04-20
期刊：
COMMUNICATIONS BIOLOGY
影响因子：
5.9
作者：
Zhang, Yingnan;Do, Khoi K.;Wang, Fuhua;Lu, Xiaoqin;Liu, John Y.;Li, Chi;Ceresa, Brian P.;Zhang, Lijun;Dean, Douglas C.;Liu, Yongqing
通讯作者：
Liu, Yongqing

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas.