Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation

Chiari I 型畸形的功能连接、大脑发育和结果

• 批准号: 10629122
• 负责人: Nico Dosenbach
• 金额: $ 16.54万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629122
• 关键词: Adolescent; Adult; Age; Anatomy; Anisotropy; Attention; Brain; Brain Stem; Cerebellar tonsil; Cerebellum; Cerebrum; Child; Child Behavior Checklist; Childhood; Clinical; Clinical Treatment; Cognition; Cognitive; Data; Data Set; Development; Diffusion Magnetic Resonance Imaging; Disease; Disease Outcome; Emotional; Emotions; Executive Dysfunction; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Headache; Health; Image; Impaired cognition; Individual; Intervention; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Moods; Needles; Neurobehavioral Manifestations; Operative Surgical Procedures; Outcome; Paresthesia; Participant; Pathologic; Pathology; Pathway interactions; Patients; Pediatric cohort; Pediatrics; Pontine structure; Positioning Attribute; Posterior Fossa; Protocols documentation; Radiology Specialty; Rest; Role; Sampling; Scanning; Severities; Short-Term Memory; Signs and Symptoms; Site; Spinal Canal; Spinal Cord; Standardization; Surgical Decompression; Symptoms; Testing; Time; Tonsil; United States National Institutes of Health; Work; anatomic imaging; arm; attentional control; behavior measurement; behavior test; behavioral phenotyping; cognitive development; cognitive function; cognitive testing; cohort; emotion regulation; emotional symptom; executive function; foramen magnum; imaging biomarker; improved; indexing; internal control; longitudinal analysis; malformation; motor control; neuroimaging; novel; outcome prediction; predictive marker; response; sham surgery; symptomatic improvement; treatment and outcome

PROJECT SUMMARY Project 2: Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation Abstract Chiari malformation (CM) is a challenging disease. Despite its anatomically well-defined pathology characterized by herniation of the cerebellar tonsils through the foramen magnum, its clinical symptoms and indications for surgical intervention are highly variable. Here we propose advanced neuroimaging with personalized connectomics acquired longitudinally, in both surgical (pre/post posterior fossa decompression) and non-surgical CM patients, to identify imaging markers for better disease characterization and outcome prediction. We are using resting state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI) to measure resting state functional connectivity (RSFC) and fractional anisotropy (FA), respectively. We are leveraging the protocols of the Adolescent Brain Cognitive Development (ABCD) Study (n = 11,874), to facilitate direct comparisons to age and demographic matched control subjects from the ABCD data set, for both imaging and cognitive/emotional metrics. In addition, we are collecting Chiari Severity Index (CSI) and Chiari Health Index in Pediatrics (CHIP) data, both of which have been developed and validated by our team specifically for CM. The longitudinal arm of this project includes an adult CM cohort, which will expand the number of participants for greater power, and allow us to test developmental CM effects in the pediatric cohort. The imaging and cognitive measures will be compared at baseline before any intervention. Then within-participant comparisons will be made before and after posterior fossa decompression (PFD) surgery to identify novel imaging markers predictive of disease outcomes and response to surgery.

项目摘要 项目2：Chiari I型畸形中的功能连通性，大脑发展和结果 抽象的 Chiari畸形（CM）是一种具有挑战性的疾病。尽管有解剖学明确的病理 特征是小脑扁桃体通过大孔的隆起，其临床症状和 手术干预的适应症高度可变。在这里，我们提出了与 个性化连接组学在手术中都获得了纵向（前/后窝减压） 和非手术CM患者，以识别成像标记以获得更好的疾病表征和结果 预言。我们使用静息状态功能性MRI（RS-FMRI）和扩散张量成像（DTI）来测量 静止状态功能连通性（RSFC）和分数各向异性（FA）。我们正在利用 青少年脑认知发展（ABCD）研究（n = 11,874）的方案，以促进直接 与ABCD数据集的年龄和人口统计学相匹配的对照对象的比较，成像和 认知/情感指标。此外，我们正在收集Chiari严重性指数（CSI）和Chiari Health指数 儿科（芯片）数据，这些数据均由我们的团队专门针对CM开发和验证。这 该项目的纵向部门包括一个成人CM队列，该队列将扩大参与者的数量 更大的功率，使我们能够测试小儿队列中的发育CM效应。成像和认知 在任何干预之前，将在基线时比较措施。然后，参与者比较将是 在后窝减压（PFD）手术之前和之后进行的，以识别新型成像标记预测性 疾病结局和对手术的反应。